Abstract
The immunoglobuline κ locus has previously been characterized by comparing the restriction patterns of the DNA of 23 Caucasoid individuals and defining various polymorphisms and haplotypes. This study has now been extended to a group of 28 Blacks and another group of 13 individuals of different ethnic origins. The predominant haplotype of the Caucasoid group, called haplotype N, was also found frequently in the other groups. Some of the restriction fragment length polymorphism markers typical of haplotype G, on the other hand, were seen 2–3 times more frequently in the black than in the Caucasoid group. Haplotype 11, which is characterized by the absence of about half of the variable gene segments (Vκ) and which had been observed in 3 out of 46 Caucasoid alleles, has been found twice in the 82 alleles of the two new groups. A number of new polymorphisms was detected and new haplotypes were defined, although the structure of the immunoglobulin κ locus seems generally to be well conserved among different populations.
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Klobeck H-G, Zimmer F-J, Combriato G, Zachau HG (1987) Linking of the human immunoglobulin Vκ and Jκ regions by chromosomal walking. Nucleic Acids Res 15. 9655–9665
Lautner-Rieske A, Huber C, Meindl A, Pargenl W, Schäble KF, Thiebe R, Zocher I. Zachau HG (1992) The human immunoglobulin κ locus. Characterization of the duplicated A region. Eur J Immunol 22:1023–1029
Lorenz, W, Schäble KF, Thiebe R, Stavnezer J, Zachau HG (1988) The Jκ proximal region of the human κ locus contains three uncommon Vκ genes which are arranged in opposite transcriptional polarities. Mol Immunol 25:479–484
Matera AG, Hellmann U, Hintz MF, Schmid CW (1990) Recently transposed Alu repeats result from multiple source genes. Nucleic Acids Res 18:6019–6023
Pargent W (1991) Doctoral Thesis, Fakultät für Biologic, Universität München
Pargent W, Meindl A, Thiebe R, Mitzel S, Zachau HG (1991a) The human immunoglobulin κ locus. Characterization of the duplicated 0 regions. Eur J Immunol 21:1821–1827
Pargent W, Schäble KF, Zachau HG (1991b) Polymorphisms and haplotypes in the human immunoglobulin κ locus. Eur J Immunol 21:1829–1835
Pech M, Smola H, Pohlenz H-D, Straubinger B, Gerl R, Zachau HG (1985) A large section of the gene locus encoding human immunoglobulin variable regions of the κ type is duplicated. J Mol Biol 183:291–299
Rappold GA, Henke A, Pohlschmid M, Huisman THJ (1992) Pseudoautosomal repeat displays higher variability in Blacks compared to Caucasians. Hum Genet 88:573–578
Schaible G (1992) Diploma Thesis, Fakultät für Chemie und Pharmazie, Universität München
Scott MG, Crimmins DL, McCourt DW, Chung G, Schäble KF, Thiebe R, Quenzel E-M, Zachau HG, Nahm MH (1991) Clonal characterization of the human IgG antibody repertoire to H. influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous. J Immunol 147:4007–4013
Weichhold GM, Klobeck H-G, Ohnheiser R, Combriato G, Zachau HG (1990) Megabase inversions in the human genome as physiological events. Nature 347:90–92
Zachau HG (1989) Immunoglobulin light chain genes of the κ type in man and mouse. In: Honjo T, Alt FW, Rabbitts TH (eds) The immunoglobulin genes. Academic Press, London San Diego, pp 91–109
Zachau HG (1990) The human immunoglobulin κ locus and some of its acrobatics. Biol Chem Hoppe Seyler 371:1–6
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Schaible, G., Rappold, G.A., Pargent, W. et al. The immunoglobulin κ locus: polymorphism and haplotypes of Caucasoid and non-Caucasoid individuals. Hum Genet 91, 261–267 (1993). https://doi.org/10.1007/BF00218268
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DOI: https://doi.org/10.1007/BF00218268