Skip to main content
Log in

Halofantrine : a new substance for treatment of multidrug-resistant malaria

  • Clinical Pharmacology
  • Published:
The clinical investigator Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Anonymous (1989) Halofantrine in the treatment of malaria. Lancet II:537–538

    Google Scholar 

  2. Bernard J, Sarrouy J, Dupasquier I (1990) Traitement du paludisme d'importation a Plasmodium falciparum per l'halofantrine. A propos de 59 observations. Med Trop (Mars) 50:167–171

    Google Scholar 

  3. Blauer G (1988) Interaction of ferriprotoporphyrin IX with the antimalarials amodiaquine and halofrantrine. Biochem Int 17:729–734

    Google Scholar 

  4. Braendli B, Loutan L, Markwalder K, Bock HL (1991) Treatment of acute malaria with halofantrine in Switzerland — preliminary results of a clinical study. In: Adam D, Lode H, Rubinstein E (ed) 17th International Congress of Chemotherapy, Berlin, June 23–28. Futuramed, Munich

    Google Scholar 

  5. Broom C (1989) Human pharmacokinetics of halofantrine hydrochloride. Parasitol Today 5 [Suppl]:15–20

    Google Scholar 

  6. Bunnag D, Harmasuta T (1989) Drug combinations for treatment and prophylaxis of multiresistant malaria. Curr J Clin Pharmacol 36 [Suppl]:A13

    Google Scholar 

  7. Couland JP, Le Bras J, Matheron S, Moriniere B, Saimot AG, Rossignol JF (1986) Treatment of imported cases of falciparum malaria in France with halofantrine. Trans R Soc Trop Med Hyg 80:615–617

    Google Scholar 

  8. Fleischer K, Eichenlaub D, Schönfeld C (1991) Die Malariavorbeugung. Dtsch Arztebl 88:1543–1548

    Google Scholar 

  9. Horton J, Parr S, Bokor L, Clemens R (1991) Clinical experience with halofantrine in the treatment of P. falciparum malaria (malaria tropica). In: Adam D, Lode H, Rubinstein E (ed) 17th International Congress of Chemotherapy, Berlin, June 23–28. Futuramed, Munich

    Google Scholar 

  10. Lobel HO, Bernard KW, Williams SL, Hightower AW, Patchen LC, Campbell CC (1991) Effectiveness and tolerance of longterm malaria prophylaxis with mefloquine. JAMA 265:361–64

    Google Scholar 

  11. Löscher T, Fleischer K, Kretschmer H, Pohle HD, Weinke T, Köhler B, Schlunk T, Schunck B, Bock HL (1991) Treatment of uncomplicated malaria with halofantrine in nonimmune adults — first clinical results in Germany. In: Adam D, Lode H, Rubinstein E (ed) 17th International Congress of Chemotherapy, Berlin, June 23–28. Futuramed, Munich

    Google Scholar 

  12. Milton KA, Edwards G, Ward SA, Orme ML'E, Breckenridge AM (1989) Pharmacokinetics of halofantrine in man: effects of food and dose size. Br J Clin Pharmacol 28:71–77

    Google Scholar 

  13. Moran JS, Bernard KW (1989) The spread of chloroquine-resistant malaria in Africa. Implications for travellers. JAMA 262:245–248

    Google Scholar 

  14. Nosten F, Ter Kuile F, Chongsuphajaisiddhi T, Luxembeurger C, Webster HK, Edstein M, Phaipun L, Thew KL, White NJ (1991) Mefloquin-resistant falciparum malaria on the Thai-Burmese border. Lancet 337:1140–1143

    Google Scholar 

  15. Oduola AMJ, Milhous WK, Salako LA, Walker O (1987) Reduced in vitro susceptibility to mefloquine in West African isolates of Plasmodium falciparum. Lancet II:1304–1305

    Google Scholar 

  16. Payne D (1987) Spread of chloroquine resistance in Plasmodium falciparum. Parasitol Today 3:241–246

    Google Scholar 

  17. Peters W, Robinson BL, Ellis DS (1987) The chemotherapy of rodent malaria XLII:halofantrine resistance. Ann Trop Med Parasitol 81:65–67

    Google Scholar 

  18. Phillips RE, Looareesuwan S, White NJ (1986) Hypoglycaemia and antimalarial drugs: quinidine and release of insuline. BMJ 292:1319–1321

    Google Scholar 

  19. Rouè R, Debord T (1988) Preliminary results. Efficacy, safety of halofantrine in the treatment of a first Plasmodium falciparum malaria attack in adults. In: Proceedings of the XIIth International Congress for Tropical Medicine & Malaria, Amsterdam, September 19–23. Excerpta Medica International Congress Series, vol 810

  20. Schuster BG, Canfield CJ (1989) Preclinical studies with halofantrine in the treatment of multidrug-resistant malaria. Parasitol Today 5 [Suppl]:3–14

    Google Scholar 

  21. Steffen R (1991) The epidemiological basis for the practice of travel medicine. In: 2nd Conference on International Travel Medicine, Program and Abstracts, Atlanta, May 9–12, p35

  22. Steffen R, Heusser R, Mächler R, Maef U, Somaini B (1989) Malaria chemoprophylaxis in 28712 European travellers to Africa: a follow-up study. In: Steffen R, Lobel HO, Haworth J, Bradley DF (eds) Travel medicine. Springer, Berlin Heidelberg New York, pp 141–144

    Google Scholar 

  23. Steffen R, Mächler R, Heusser R, Naef UR (1990) Malaria Prophylaxe bundesdeutscher Afrikareisender. Dtsch Med Wochenschr 115:290–294

    Google Scholar 

  24. Suebsaent L, Wernsdorfer WH, Rooney W (1986) Sensitivity to quinine and mefloquine of Plasmodium falciparum in Thailand. Bull WHO 64:759–65

    Google Scholar 

  25. Warhurst DC, Diribe 00 (1988) Effect of halofantrine on the proton pump of intraerythrozyte Plasmodium berghei. XIIth International Congress for Tropical Medicine & Malaria, Amsterdam, September 19–23. Treatment of malaria: artemisinine and halofantrine. Excerpta Medica International Congress Series, vol 810

  26. Webster HK, Boudreau EF, Pavanand K, Yongvanitchit K, Pang LW (1985) Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method. Am J Trop Med Hyg 34:228–235

    Google Scholar 

  27. Wiselogle FY (1946) A survey of antimalarial drugs 1941–1945. Edwards, Ann Arbor, pp 309–24

    Google Scholar 

  28. World Health Organization (1990) World malaria situation. Wkly Epidemiol Rec 65:189–196

    Google Scholar 

  29. World Health Organization (1991) Vaccination and health advice. In: International travel an health. WHO, Geneva

    Google Scholar 

  30. World Tourism Organization (1991) World tourism 1970–1990, WTO, Madrid

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nothdurft, H.D., Clemens, R., Bock, H.L. et al. Halofantrine : a new substance for treatment of multidrug-resistant malaria. Clin Investig 71, 69–73 (1993). https://doi.org/10.1007/BF00210972

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00210972

Key words

Navigation