Abstract
The gene responsible for hereditary hemochromatosis has been shown to be closely linked to the HLA-A and D6S105 loci on the short arm of chromosome 6. Efforts at mapping the disease gene have been hindered, however, by a lack of informative recombinants in this region. We have identified two recombinant individuals in a single affected family and have confirmed recombination by analysis of 16 polymorphic markers located near HLA-A and D6S105. One of the recombinants provides evidence for the location of the hemochromatosis gene telomeric to HLA-F.
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Calandro, L.M., Baer, D.M. & Sensabaugh, G.F. Characterization of a recombinant that locates the hereditary hemochromatosis gene telomeric to HLA-F. Hum Genet 96, 339–342 (1995). https://doi.org/10.1007/BF00210419
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DOI: https://doi.org/10.1007/BF00210419