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Medicobiological and genetic studies on alcoholism Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality

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Abbreviations

ADH:

alcohol dehydrogenase

ALDH:

aldehyde dehydrogenase

NAD:

nicotinamide adenine dinucleotide

CNS:

central nervous system

NMDA:

N-methyl-das-partate

GABA:

γ-aminobutyric acid

FAS:

fetal alcohol syndrome

References

  1. Abel EL, Sokol RJ (1987) Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies. Drug Alcohol Depend 19:51–79

    Google Scholar 

  2. Agarwal DP, Goedde HW (1987a) Human aldehyde dehydrogenase isozymes and alcohol sensitivity. In: Rattazzi MC, Scandalios JG, Whitt GS (eds) Isozymes: current topics in biological and medical research, vol 16. Liss, New York, pp 21–48

    Google Scholar 

  3. Agarwal DP, Goedde HW (1987b) Genetic variation in alcohol metabolizing enzymes: implications in alcohol use and abuse. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. AR Liss, New York, pp 121–140

    Google Scholar 

  4. Agarwal DP, Goedde HW (1989) Human aldehyde dehydrogenases: their role in alcoholism. Alcohol 6:517–523

    Google Scholar 

  5. Agarwal DP, Goedde HW (1990) Alcohol metabolism, alcohol intolerance and alcoholism. Biochemical and pharmacological approaches. Springer, Berlin Heidelberg New York

    Google Scholar 

  6. Svenska Institutet (1988) Alkohol and Rauschgifte in Schweden. SI, Stockholm

    Google Scholar 

  7. Armstrong RW (1986) Tobacco and alcohol use among urban Malaysians in 1980. Int J Addict 20:1803–1808

    Google Scholar 

  8. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeesawaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. J Am Med Assoc 263:2050–2060

    Google Scholar 

  9. Bohman M, Cloniger CR, Knorring AL v, Sigvardsson S (1984) An adoption study of somatoform disorders. III. Cross-fostering analysis and genetic relationship to alcoholism and criminality. Arch Gen Psychiatry 41:872–878

    Google Scholar 

  10. Caetano R (1989) Drinking patterns and alcohol problems in a national sample of US Hispanics. In: Spiegler DLS, Tate DA, Aitken SS, Christian CM (eds) Alcohol use among US ethnic minorities. (Research monograph no 18) US Department of Health and Human Services (DHHS), Rockville, pp 147–162

    Google Scholar 

  11. Carlini BH, Press MLN, Fernandes R, Masur J (1986) Alcohol use among adolescents in Sao Paulo, Brazil. Drug Alcohol Depend 18:235–246

    Google Scholar 

  12. Chi I, Lubben JE, Kitano HHL (1989) Differences in drinking behavior among three Asian-American groups. J Stud Alcohol 50:15–23

    Google Scholar 

  13. Christian CM, Zobeck TS, Malin HJ, Hitchcock DC (1989) Self-reported alcohol use and abuse among Mexican Americans. In: Spiegler DLS, Tate DA, Aitken SS, Christian CM (eds) Alcohol use among US ethnic minorities. (Research monograph no 18) US Department of Health and Human Services (DHHS), Rockville, pp 425–438

    Google Scholar 

  14. Cloninger CR (1987) Recent advances in family studies of alcoholism. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. Liss, New York, pp 47–60

    Google Scholar 

  15. Conneally PM (1991) Association between the D2 dopamine receptor gene and alcoholism. Arch Gen Psychiatry 48:664–666

    Google Scholar 

  16. Czeizel A, Benkmann H-G, Goedde HW (1991) Genetic aspects of the Hungarian population: ethnic aspects, genetic markers, ecogenetics and disease spectrum. Springer, Berlin Heidelberg New York

    Google Scholar 

  17. Lint J de (1976) The epidemiology of alcoholism with specific references to sociocultural factors. In: Everett MW, Waddel JO, Heath DB (eds) Cross-cultural approaches to the study of alcohol. Mouton, The Hague, pp 323–339

    Google Scholar 

  18. Dever EJ, Cloninger CR (1989) Genetics of alcoholism. Annu Rev Genet 23:19–36

    Google Scholar 

  19. Dinwiddie SH, Cloninger CR (1989) Family and adoption studies of alcoholism. In: Goedde HW, Agarwal DP (eds) Alcoholism: biomedical and genetic aspects. Pergamon Press, New York, pp 259–276

    Google Scholar 

  20. Ehrig T, Bosron WF, Li T-K (1990) Alcohol and aldehyde dehydrogenase. Alcohol Alcohol 25:105–116

    Google Scholar 

  21. Enomoto N, Takase S, Yashuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141–144

    Google Scholar 

  22. Farris JJ, Jones BM (1978) Ethanol metabolism in male American Indians and whites. Alcohol Clin Exp Res 2:77–82

    Google Scholar 

  23. Fenna D, Mix L, Schaefer O, Gilbert JAL (1971) Ethanol metabolism in various racial groups. Can Med Assoc J 105:472–475

    Google Scholar 

  24. Franklin JE (1989) Alcoholism among blacks. Hosp Commun Psychiatry 40:1120–1127

    Google Scholar 

  25. Gilbert MJ (1989) Alcohol related practices, problems and norms among Mexican Americans: an overview. In: Spiegler DLS, Tate DA, Aitken SS, Christian CM (eds) Alcohol use among US ethnic minorities (Research monograph no 18) US Department of Health and Human Services (DHHS), Rockville, pp 115–134

    Google Scholar 

  26. Goedde HW, Agarwal DP (1986) Aldehyde oxidation: ethnic variation in metabolism and response. In: Kalow W, Goedde HW, Agarwal DP (eds) Ethnic differences in reactions to drugs and xenobiotics. Liss, New York, pp 113–138

    Google Scholar 

  27. Goedde HW, Agarwal DP (1989) Acetaldehyde metabolism: genetic variation and physiological implications. In: Goedde HW, Agarwal DP (eds) Alcoholism: biomedical and genetic aspects. Pergamon, New York, pp 21–56

    Google Scholar 

  28. Goedde HW, Harada S, Agarwal DP (1979) Racial differences in alcohol sensitivity: a new hypothesis. Hum Genet 51:331–334

    Google Scholar 

  29. Goedde HW, Agarwal DP, Eckey R, Harada S (1985) Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity. Alcohol 2:283–289

    Google Scholar 

  30. Goedde HW, Singh S, Agarwal DP, Fritze G, Stapel K, Paik YK (1989) Genotyping of mitochondria aldehyde dehydrogenase in blood samples using allele-specific oligonucteotides. Hum Genet 81:305–307

    Google Scholar 

  31. Goedde HW, Agarwal DP, Fritze G, Meter-Tackmann D, Singh S, Benkmann G, Bhatia K, Chen LZ, Fang B, Hisker R, Paik YK, Rothhammer F, Saha N, Segal B, Srivastava LM, Czeizel A (1992) Frequency of ADH2 and ALDH2 genotypes in different populations and implications for alcohol sensitivity and alcohol drinking habits. Hum Genet 88:344–346

    Google Scholar 

  32. Goodwin DW (1987) Adoption studies of alcoholism. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. Liss, New York, pp 60–70

    Google Scholar 

  33. Gurling HMD, Murray RM (1987) Genetic influence, brain morphology, and cognitive deficits in alcoholic twins. In: Goedde HW, Agarwal DP (eds) Genetics and alcoholism. Liss New York pp 71–82

    Google Scholar 

  34. Harada S, Agarwal DP, Goedde HW (1981) Aldehyde dehydrogenase deficiency as cause of facial flushing reaction to alcohol in Japanese. Lancet II:982

    Google Scholar 

  35. Harada S, Agarwal DP, Goedde HW (1985) Aldehyde dehydrogenase polymorphism and alcohol metabolism in alcoholics. Alcohol 2:391–392

    Google Scholar 

  36. Heath AC, Meyer J, Eaves LJ, Martin NG (1991) The inheritance of alcohol consumption patterns in a general twin sample. I. Multidimensional scaling of quantity/frequency data. J Stud Alcohol 52:345–352

    Google Scholar 

  37. Heok KE (1990) Drinking habits of elderly Chinese. Br J Addict 85:571–573

    Google Scholar 

  38. Herd D (1989) The epidemiology of drinking patterns and alcohol-related problems among US blacks. In: Spiegler DLS, Tate DA, Aitken SS, Christian CM (eds) Alcohol use among US ethnic minorities. (Research monograph no 18) US Department of Health and Human Services (DHHS), Rockville, pp 3–50

    Google Scholar 

  39. Hong OT, Isralowitz RE (1989) Cross-cultural study of alcohol behaviour among Singapore college students. Br J Addict 84:319–321

    Google Scholar 

  40. Hughes K, Yeo PPB, Lun KC, Thai AC, Wang KW, Cheah JS (1990) Alcohol consumption in Chinese, Malays and Indians in Singapore. Ann Acad Med Singapore 19:330–332

    Google Scholar 

  41. Johnson RC, Nagoshi CT, Schwitters SY (1984) Further investigation of social, ethnic differences and of family resemblance in flushing in response to alcohol. Behav Genet 14:171–178

    Google Scholar 

  42. Kamien M (1975) Aborigines and alcohol: intake, effects and social implications in a rural community in Western New South Wales. Med J Aust 1: 291–298

    Google Scholar 

  43. Kaprio J, Koskenvuo MD, Longinvaino H, Romanov K, Sarna S, Rose RJ (1987) Genetic influences on use and abuse of alcohol: a study of 5638 adult Finnish twin brothers. Alcohol Clin Exp Res 11:349–356

    Google Scholar 

  44. Kitano HHL, Lubben JE, Chi I (1988) Predicting Japanese American drinking behavior. Int J Addict 23:417–428

    Google Scholar 

  45. Klatsky AL (1987) The cardiovascular effects of alcohol. Alcohol Alochol Suppl 1:117–124

    Google Scholar 

  46. Klatsky AL, Siegelaub AB, Landy C, Friedman GD (1983) Racial patterns of alcoholic beverage use. Alcohol Clin Exp Res 7:372–377

    Google Scholar 

  47. Kono H, Saito S, Shimada K, Nakagawa J (1977) Drinking habits of the Japanese. Actual drinking habits and problem drinking tendencies. Leisure Development Center, Tokyo, pp 1–15

    Google Scholar 

  48. Lee CK (1987) The epidemiological study of mental disorders in Korea (X) — Prevalence of alcoholism. Seoul J Psychiatr 13:15–25

    Google Scholar 

  49. Lee JA (1987) Chinese, alcohol and flushing: sociohistorical and biobehavioral considerations. J Psychoactive Drugs 19:319–327

    Google Scholar 

  50. Lieber CS (1985) Alcohol and the liver: metabolism of ethanol, metabolic effects and pathogenesis of injury. Acta Med Scand[Suppl] 703:11–55

    Google Scholar 

  51. Lubben JE, Chi I, Kitano HHL (1987) Exploring Filipino American drinking behaviour. J Stud Alcohol 49:26–29

    Google Scholar 

  52. Lubben JE, Chi I, Kitano HHL (1989) The relative influence of selected social factors on Korean drinking behavior in Los Angeles. Adv Alcohol Subst Abuse 8:1–17

    Google Scholar 

  53. Makkai T, McAllister J (1990) Alcohol consumption across the lifecycle in Australia, 1985–1988. Drug Alcohol Depend 25:305–313

    Google Scholar 

  54. Mardones J (1984) Consideraciones sobre el alcoholismo en Chile. Vida Medica 35:38–41

    Google Scholar 

  55. Marshall M (1988) Alcohol consumption as a public health problem in Papua New Guinea. Int J Addict 23:573–589

    Google Scholar 

  56. Marshall M, Forsyth ST, Sumanop FH, Piau-Lynch A (1985) Alcohol research in Papua New Guinea. Implications for health care workers. Papua New Guinea Med J 28:183–193

    Google Scholar 

  57. Medina E, Kaempfer AM (1974) Epidemiologia de la cirrosis hepática en Chile. Revista Medica de Chile 102:466–476

    Google Scholar 

  58. Mohan D, Sundaram KR, Advani GB, Sharma HK, Bajaj JS (1984) Alcohol abuse in a rural community in India. Part 11: characteristics of alcohol users. Drug Alcohol Depend 14:121–128

    Google Scholar 

  59. Moser J (1980) Prevention of alcohol-related problems. An international review of preventive measures, policies and programmes. Alcoholism and Drug Addiction Research Foundation, Toronto

    Google Scholar 

  60. National Heart Foundation of Australia (1983) Risk factor prevalence study. No 2: survey methods

  61. Ohara K, Suzuki Y, Sugita T, Kobayashi K, Tamefusa K, Hattori S, Ohara K (1989) Mortality among alcoholics discharged from a Japanese hospital. Br J Addict 84:287–291

    Google Scholar 

  62. Ohmori T, Koyama T, Chen CC, Yeh EK, Reyes BV, Yamashita I (1986) The role of aldehyde dehydrogenase isozyme variance in alcohol sensitivity, drinking habits formation and the development of alcoholism in Japan, Taiwan and the Philippines. Prog Neuropsychopharmacol Biol Psychiatr 10:229–235

    Google Scholar 

  63. Park JY, Huang YH, Nagoshi CT, Yuen S, Johnson RC, Ching CA, Bowman KS (1984) The flushing response to alcohol use among Koreans and Taiwanese. J Stud Alcohol 45:481–485

    Google Scholar 

  64. Parsian A, Todd RD, Devor EJ, O'Malley KL, Suarez BK, Reich T, Cloninger CR (1991) Alcoholism and alleles of the human D2 dopamine receptor locus. Arch Gen Psychiatr 48:655–663

    Google Scholar 

  65. Rahkonen O, Ahlström S (1989) Trends in drinking habits among Finnish youth from 1973 to 1987. Br J Addiction 84:1075–1083

    Google Scholar 

  66. Reed TE (1985) Ethnic differences in alcohol use, abuse, and sensitivity: a review with genetic interpretation. See Biol 32:195–209

    Google Scholar 

  67. Reed TE, Hanna JM (1986) Between- and within-race variation in acute cardiovascular responses to alcohol: evidence for genetic determination in normal males in three races. Behav Genet 16:585–598

    Google Scholar 

  68. Requelme SH (1981) Übermäßiger Alkoholkonsum in Chile. Entstehungsbedingungen und sozialmedizinische Bewältigungsschritte. Jahrbuch für kritische Medizin 7:146–158

    Google Scholar 

  69. Rocha-Silva L (1988) Attitudes of urban South Africans towards drinking and drunkeness. Drug Alcohol Depend 21:203–212

    Google Scholar 

  70. Rommelspacher H, Wanke K, Caspari D, Topel H (1989) Alkoholismusforschung im internationalen Vergleich. Dtsch Arztebl 43: C-191–192

    Google Scholar 

  71. Saito S (1978) “Heavy drinkers” and “problem drinkers” in Japanese general population. Public Health 42:309–317

    Google Scholar 

  72. Salaspuro M, Lindros KO (1985) Metabolism and toxicity of acetaldehyde. In: Seitz HK, Kommerell B (eds) Alcohol related diseases in gastroenterology. Springer, Berlin Heidelberg New York, pp 106–123

    Google Scholar 

  73. Schuckit MA (1989) Biomedical and genetic markers of alcoholism. In: Goedde HW, Agarwal DP (eds) Alcoholism: biomedical and genetic aspects. Pergamon Press, New York, pp 290–302

    Google Scholar 

  74. SCJAOD (1989) Report 89. Trends in alcohol and drug use in Sweden. Swedish Council for Information on Alcohol and Other Drugs, Stockholm

    Google Scholar 

  75. Shibuya A, Yoshida A (1988) Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver disease: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH 12 ) with the disease. Am J Hum Genet 43:744–748

    Google Scholar 

  76. Singh G (1989) Epidemiology of alcohol abuse in India. In: Ray R, Pickens RW (eds) Proceedings of the Indo-US symposium on alcohol and drug abuse. National Institute of Mental Health and Neuro Sciences, Bangalore, pp 3–11

    Google Scholar 

  77. Singh S, Fritze G, Fang B, Harada S, Paik YK, Eckey R, Agarwal DP, Goedde HW (1989) Inheritance of mitochondrial aldehyde dehydrogenase: genotyping in Chinese, Japanese and South Korean families reveals a dominance of the mutant allele. Hum Genet 83:119–121

    Google Scholar 

  78. Suwaki H, Ohara H (1985) Alcohol-induced facial flushing and drinking behavior in Japanese men. J Stud Alcohol 46:196–198

    Google Scholar 

  79. Tabakoff B, Hoffman PL (1991) Recent advances in alcohol research 1990. Alcohol Alcohol Suppl 1:1–7

    Google Scholar 

  80. Tarter RE, Arria AM, Thiel DH van (1989) Neurobehavioral disorders associated with chronic alcohol abuse. In: Goedde HW, Agarwal DP (eds) Alcoholism: biomedical and genetic aspects. Pergamon Press, New York, pp 113–130

    Google Scholar 

  81. Téllez C (1984) Chile: alcoholism in a wine-drinking country. Br J Addict 79:447–448

    Google Scholar 

  82. Thacker SB, Veech RL, Vernon AA, Rutstein DD (1984) Genetic and biochemical factors relevant to alcoholism. Alcohol Clin Exp Res 8:374–383

    Google Scholar 

  83. Thommasson HR, Edenberg HJ, Crabb DW, Mai X-L, Jerome RE, Li T-K, Wang S-P, Lin Y-T, Lu R-B, Yin S-J (1991) Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677–681

    Google Scholar 

  84. Thomson N (1984) Aboriginal health-current status. Aust NZ J Med 14:705–718

    Google Scholar 

  85. Wartburg JP von (1984) Biochemische Aspekte des Alkoholismus. Therapiewoche 34:3244–3250

    Google Scholar 

  86. Wilson JR, McClearn GE, Johnson RC (1978) Ethnic variation in the use and effects of alcohol. Drug Alcohol Depend 3:147–151

    Google Scholar 

  87. Wolff PH (1973) Vasomotor sensitivity to alcohol in diverse Mongoloid populations. Am J Hum Genet 25:193–199

    Google Scholar 

  88. Yamashita I, Ohmori T, Koyama T, Mori H, Boyadijie S, Kielholz P, Gastpar M, Moussaoni D, Bonzekraoni M (1990) Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO collaborative study. Jpn J Psychiatr 44:79–84

    Google Scholar 

  89. Yeh E-K, Hwu H-G, Chen C-C, Yeh Y-L (1989) Alcoholism: a low risk disorder for Chinese: Community surveys in Taiwan. In: Sun GY, Rudeen PK, Wood WG, Wei YH, Sun AY (eds) Molecular mechanisms of alcohol. Neurobiology and metabolism. Humana Press, Clifton, pp 335–355

    Google Scholar 

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Agarwal, D.P., Goedde, H.W. Medicobiological and genetic studies on alcoholism Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality. Clin Investig 70, 465–477 (1992). https://doi.org/10.1007/BF00210227

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