Summary
1,25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 have antagonistic effects on the acellular bone of the tilapia Sarotherodon mossambicus. 1,25-Dihydroxyvitamin D3 inhibits the activity of the lining osteoblasts. Prolonged administration leads to demineralization of the bone matrix.
Injection of 24,25-dihydroxyvitamin D3 induces structural signs of greatly enhanced appositional bone growth within three days. No effects were observed on the mineral content of pre-existing bone.
Both 1,25- and 24,25-dihydroxyvitamin D3 may have distinct, but different physiological functions in fish.
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Bonga, S.E.W., Lammers, P.I. & van der Meij, J.C.A. Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus . Cell Tissue Res. 228, 117–126 (1983). https://doi.org/10.1007/BF00206270
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DOI: https://doi.org/10.1007/BF00206270