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Immunoregulating activity of tumor-associated macrophages

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Summary

In this report, we examine the antigen nonspecific immunoregulating activity of macrophages isolated from the murine methylcholanthrene-induced fibrosarcoma FSA. These cells were shown to enhance the primary anti-CRBC PFC response of whole normal spleen cells in a dose-dependent fashion. This function was associated with a subpopulation of large Ia-negative macrophages and was mediated by a soluble macrophage-derived factor that appeared to act by stimulating the proliferation and/or differentiation of antigen-reactive T cells. The relationship of this factor to previously described monokines is discussed.

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Authors and Affiliations

  1. Lincoln's Inn Fields, Imperial Cancer Research Fund, WC2A 3PX, London, England

    Graeme J. Dougherty

  2. Department of Radiation Oncology and Jonsson Comprehensive Cancer Center, UCLA Center for Health Sciences, 90024, Los Angeles, CA, USA

    William H. McBride

Authors
  1. Graeme J. Dougherty
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  2. William H. McBride
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Dougherty, G.J., McBride, W.H. Immunoregulating activity of tumor-associated macrophages. Cancer Immunol Immunother 23, 67–72 (1986). https://doi.org/10.1007/BF00205558

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  • DOI: https://doi.org/10.1007/BF00205558

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