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Silica abrogation of mycobacterial adjuvant contact suppression of tumor growth in rats and athymic mice

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Summary

Intraperitoneal administration of silica abrogated the adjuvant contact suppressive effect of BCG and its methanol extraction residue for rat tumors in syngeneic recipients and in athymic mice. These findings suggest that such tumor suppression is mediated by local activation of host macrophages.

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Authors and Affiliations

  1. Cancer Research Campaign Laboratories, The University, NG7 2RD, University Park, Nottingham, England

    D. G. Hopper, M. V. Pimm & R. W. Baldwin

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  1. D. G. Hopper
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  2. M. V. Pimm
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  3. R. W. Baldwin
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Hopper, D.G., Pimm, M.V. & Baldwin, R.W. Silica abrogation of mycobacterial adjuvant contact suppression of tumor growth in rats and athymic mice. Cancer Immunol Immunother 1, 143–144 (1976). https://doi.org/10.1007/BF00205457

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