Abstract
In this study, concentrations of some major and minor elements were determined in the larynx tissues with and without cancer, and results obtained were statistically compared. No meaningful differences were found between sodium, potassium, calcium and copper concentrations in cancer tissues, corresponding cancer-free adjacent tissues and in control larynx tissues. Phosphate concentrations of the cancer tissues were higher compared with cancer-free adjacent tissues and control tissues. Iron, zinc and magnesium concentrations were found increased in both cancer and corresponding cancer-free adjacent tissues relative to control values. Intra- and inter-element correlations established within and between groups indicated that relations between elements were also disordered in the cancer tissues. We suggest that the changed element status of cancerous larynx tissues may arise from increased requirements of cancer tissues for some elements such as iron, zinc, magnesium and phosphate.
Similar content being viewed by others
References
Danielson A, Stinnes E. 1970 A study of some selected trace elements in normal and cancerous tissues by neutron activation analysis. J Nucl Med 11, 260–264.
De Jeorge FB, Paiva L, Mion D, et al. 1966 Biochemical studies on copper, copper oxidase, magnesium, sulphur, calcium and phosphorus in cancer of the larynx. Acta Otolaryngol 61, 454.
Drozdz M, Gierk T, Jendryczko A, et al. 1989 Zinc, vitamin A and E, and retinol-binding protein in sera of patients with cancer of the larynx. Neoplasma 36, 357–362.
Durak I, Ekinci C, Canbolat O, et al. 1991 Kanserli mide ve meme dokularinda demir, bakir, çinko ve magnezyum konsantrasyonlarinin tayini. AÜ Tip Fakültesi Mecumuasi 44, 529–536.
Edgar ND, Howard H. 1989 Discriminant analysis of trace element distribution in normal and malignant human tissues. Cancer Res 49, 4210–4215.
Fisher GL, Byers VS, Shifrine M, et al. 1976 Copper and zinc levels in serum from human patients with sarcomas. Cancer 37, 356–363.
Garber CC, Miller RC. 1983 Revisions of the 1963 semidine HCl standard method for inorganic phosphorus. Clin Chem 29, 184–188.
Hrgovic M, Tessmer CF, Thomas FB, et al. 1973 Significance of serum copper levels in adult patients with Hodgkins disease. Cancer 31, 1337.
Inutsuka S, Araki S, Kusaba I, et al. 1973 Blood copper and zinc content of patients with malignant tumors. Rinsho, Byoii, 21 632.
Inutsuka, Araki S. 1978 Plasma copper and zinc levels in patients with malignant tumors of digestive organs. Cancer 42, 626–631.
Kirkbright GF, 1980 Atomic Absorption Spectroscopy in Elemental Analysis of biological materials. Technical Report Series 197. IAEA: Vienna; 141–145.
Lappalainen R, Knuuttila M, Lammi S, et al. 1982 Zn and Cu content in human cancellous bone. Acta Orthop Scand 53, 51–55.
Mellow MH, Layne EA, Lipman TO, et al. 1983 Plasma zinc and vitamin A in human squamous carcinoma of the esophagus. Cancer 51, 1615–1620.
Mulay IL, Roy R, Knox BE, et al. 1971 Trace metal analysis of cancerous and non cancerous human tissue. J Natl Cancer Inst 47, 1–13.
Murray H, Rosato FE, Fletcher MJ. 1970 Serum and tissue calcium in human breast carcinoma. Cancer Res 30, 615–616.
Renade SS, Panday VK. 1984 Transition metals in human cancer II. Sci Total Environ 40, 245–257.
Santoliquido PM, Southwick HW. 1976 Trace metal levels in cancer of the breast. Surg Gynecol Obstet 142, 65–70.
Schwartz MK. 1975 Role of trace elements in cancer. Cancer Res 35, 3481–3487.
Schwartz AE, Leddicote GW, Fink W, et al. 1974 Trace elements in normal and molignant human breast tissue. Surgery 76, 325–329.
Seltzer MH, Rosato FE, Fletcher MJ. 1970 Serum and tissue calcium in human breast carcinoma. Cancer Res 30, 615–616.
Sherif LR, Howard H. 1984 Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Res 44, 5390–5394.
Sigel H, ed. 1980 Metal Ions in Biological Systems: Carcinogenicity and Metal Ions, Vol. 10. New York: Marcel Dekker.
Sunderman FW Jr. 1978 Carcinogenic effects of metals. Fed Proc 37, 40–46.
Tietz NW, Pruden EL, Anderson OS. 1986 Electrolytes, blood gases, and acid-base balance. In: Tietz NW, ed. Textbook of Clinical Chemistry. Philadelphia: Saunders; 1177–1179.
Tipton IH. 1960 The distribution of trace metals in the human body. In: Seven and Jhonson, eds. Metal Binding in Medicine, Philadelphia, PA: Lippincott; 27–42.
Tsilyunyk IT, Ishchenko MM, Rusenko SV. 1965 Content of copper and maganese in the blood serum of patients with pulmonary cancer. Klin Med 43, 18.
Valcovic V. 1980 Analysis of Biological Material for Trace Elements Using X-Ray Spectroscopy. Boca Raton, FL: CRC Press; 125–143.
Wright EB, Dormandy TL. 1972 Liver zinc in carcinoma. Nature 166, 237.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Durak, İ., Kavutcu, M., Canbolat, O. et al. Concentrations of some major and minor elements in larynx tissues with and without cancer. Biometals 7, 45–48 (1994). https://doi.org/10.1007/BF00205193
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00205193