Summary
We have carried out cytogenetic studies, using the G-banding technique, in peripheral blood lymphocytes of 10 patients affected by breast carcinoma. The frequency of aberrant metaphases (7.36%) is significantly different from that of our laboratory controls (3.76% of aberrant metaphases) but not from that detected in patients suffering from bladder cancer (10.64%) and Hodgkin's disease (11.03%), two conditions that have previously been described as chromosomally unstable. Our results suggest that breast carcinoma patients show a degree of chromosomal instability that could be related to a predisposition to neoplastic disease.
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Barrios, L., Caballín, M.R., Miró, R. et al. Chromosomal instability in breast cancer patients. Hum Genet 88, 39–41 (1991). https://doi.org/10.1007/BF00204926
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DOI: https://doi.org/10.1007/BF00204926