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Annual evaluation of hip joints and hands for radiographic signs of Aβ2M-amyloidosis in long-term hemodialysis patients

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Abstract

Radiographs of hand and hip joints of 15 hemodialysis patients taken annually over at least 15 years were evaluated in this retrospective study. We looked for signs of Aβ2M-amyloidosis such as lucencies, erosions, and soft tissue swelling. The femoral head-soft tissue distance (FHSTD) was used to estimate the soft tissue swelling of the hips. The number and size of lucencies, the number of erosions, and the FHSTD increased during dialysis. Both hyperparathyroidism and failure of renal allograft transplantation influenced the development of lucencies and erosions after 15 years. The FHSTD at the start of the dialysis appeared to be an independent prognostic factor for the lucencies of the hips and hands. We conclude that the radiological signs of Aβ2M-amyloidosis are influenced not only by the duration of dialysis, but also by age, failure of renal transplantation, hyperparathyroidism and the FHSTD at the start of dialysis.

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Authors and Affiliations

  1. Department of Radiology, University Hospital, Groningen, The Netherlands

    Alfons G. A. Kamphuis M.D. & Cornelis J. P. Thijn M.D., Ph.D.

  2. Division of Nephrology, University Hospital, Groningen, The Netherlands

    Willem Geerlings M.D.

  3. Division of Rheumatology, University Hospital, Groningen, The Netherlands

    Bouke P. C. Hazenberg M.D.

Authors
  1. Alfons G. A. Kamphuis M.D.
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  2. Willem Geerlings M.D.
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  3. Bouke P. C. Hazenberg M.D.
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  4. Cornelis J. P. Thijn M.D., Ph.D.
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Kamphuis, A.G.A., Geerlings, W., Hazenberg, B.P.C. et al. Annual evaluation of hip joints and hands for radiographic signs of Aβ2M-amyloidosis in long-term hemodialysis patients. Skeletal Radiol. 23, 421–427 (1994). https://doi.org/10.1007/BF00204602

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