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Scintigraphic evaluation of tumor regression during preoperative chemotherapy of osteosarcoma

Correlation of 99mtc-methylene diphosphonate parametric imaging with surgical histopathology

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Abstract

The effect of preoperative chemotherapy (PCT) on the uptake of 99mTc-labeled diphosphonates into tumor bone was quantitatively assessed from serial scan studies of 30 osteosarcomas and correlated with the histomorphological changes determined from the surgical specimens. The parametric images of the tumor blood pool and labeled methylene diphosphonate (99mTc-MDP) plasma clearance by the tumor bone enabled a sensitive distinction to be made preoperatively between a good (>90% tumor cell destruction) and a poor (<90% tumor cell destruction) tumor response. Overall accuracy in presurgical prediction of tumor regression was found to be 88% and 96% for the blood pool and 99mTc-MDP clearance measurements, respectively (P≤0.0004). In addition, it proved possible to localize resisting areas of viable tumor up to 1.0 cm in diameter. Even at the half-way stage of PCT, a poor response could be reliably predicted (overall accuracy 91% and 100%, respectively; p≤0.011). Therefore, 99mTc-MDP parametric imaging is a highly sensitive and specific modality for an objective and accurate assessment of tumor regression during PCT of osteosarcoma.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg, Germany

    J. Knop M.D.

  2. Department of Osteopathology, University Hospital Eppendorf, Hamburg, Germany

    G. Delling M.D.

  3. Orthopedic, University Hospital Eppendorf, Hamburg, Germany

    U. Heise M.D.

  4. Pediatric Clinic, Division for Hematology and Oncology, University Hospital Eppendorf, Hamburg, Germany

    K. Winkler M.D.

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  1. J. Knop M.D.
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  2. G. Delling M.D.
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  3. U. Heise M.D.
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  4. K. Winkler M.D.
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Knop, J., Delling, G., Heise, U. et al. Scintigraphic evaluation of tumor regression during preoperative chemotherapy of osteosarcoma. Skeletal Radiol. 19, 165–172 (1990). https://doi.org/10.1007/BF00204090

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