Skip to main content
Log in

Effects of air pollution on hematological and plasma parameters in Apodemus sylvaticus and Mus musculus

  • Published:
Archives of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

The effects of atmospheric air pollution on some hematological and plasma parameters, activity, and food and water consumption in Apodemus sylvaticus (wood mouse) and Mus musculus (mouse) were studied. The studies were undertaken in the area of Cercs (polluted area in Spain), where there is a coal-fired power plant that emanates SO2, NOx, and particles, and the area of St. Jaume de Frontanyà (nonpolluted area), located 40 km from the area of Cercs, with similar climatology, relief, and altitude, but without air pollution. Apodemus sylvaticus were captured in the field and Mus musculus were placed in cages in both studied areas. The results showed that there is a significant decrease in hematocrit, and a significant increase in leucocyte number, mean corpuscular hemoglobin concentration, osmolality, and γ-globulin in Mus musculus, and a decrease in albumin (%) and albumin/globulin index in Apodemus sylvaticus. A negative correlation between hematocrit values and pollution was found. In mice placed in cages in the polluted area a slight but significant decrease in water and food consumption, and slower activity, was observed. The results suggest that pollution could induce a decrease in water and food consumption, which may be due to an observed reduction in activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Baskurt OK (1988) Acute hematologic and hemorheologic effects of sulphur dioxide inhalation. Arch Environ Health 43(5):344–348

    Google Scholar 

  • Baskurt OK, Levi E, Andac SO, Caglayan S (1990) Effects of sulfur dioxide inhalation on erythrocyte deformability. Clin Hemorheol 10(5):485–489

    Google Scholar 

  • Campbell CS, Schwarz NB, Gorshi FM (1977) The role of adrenal and ovarian steroids in the control of serum LH and FSH. Endocrinology 101:162–172

    Google Scholar 

  • Capel-Edwards K., Hall DE, Sanson AG (1968) Hematological changes observed in female beagle dogs given ethynylestradiol. Toxicol Appl Pharmacol 20:319–326

    Google Scholar 

  • Dacie JV, Lewis SM (1975) Practical haematology, 5th edn. Churchill Livingstone, Edinburgh, pp 202

    Google Scholar 

  • Drabkin DL, Austin JH (1935) Spectrophotometric studies. V.A. technique for the analysis of undiluted blood and concentrated hemoglobin solution. J Biol Chem 112:105–115

    Google Scholar 

  • Dikmenoglu N, Baskurt OK, Levi E, Caglayan S, Guler S (1991) How does sulphur dioxide affect erythrocyte deformability. Clin Hemorheol 11(5):497–499

    Google Scholar 

  • Gordon AS, Zanjani ED, McLaurin WD (1968) The renal erythropoietic factor (REF) VII. Relation to sex steroid hormone effects on erythropoiesis. Proc Soc Exp Biol Med 129:871–874

    Google Scholar 

  • Gorriz A, Llacuna S, Durfort M, Nadal J (1994) A study of the ciliar tracheal epithelium on passerine birds and small mammals subjected to air pollution: Ultrastructural study. Arch Environ Contam Toxicol 27:137–142

    Google Scholar 

  • Haider SS (1985) Effects of exhaust pollutants sulfur dioxide on lipid metabolism of guinea pig organs. Ind Health 23:81–87

    Google Scholar 

  • Kohn J (1957) A cellulose acetate supporting medium for zone electrophoresis. Clin Chim Acta 2:297–303

    Google Scholar 

  • Kucera E (1980) Emissions distribution reflected in wild rodent tissues. Submission to the Clean Environment Commission Hearing in Connection with Hudson Bay Mining and Smelting XCo., Ltd. 15 pp

  • Kucera E (1983) Monitoring smelter emissions using small mammals as indicators. Manitoba Department Environmental Workplace Safety and Health 83(14):16 pp

  • Kucera E (1988) Effects of smelter emissions on the hemogram of the deer mouse (Peromyscus maniculatus). Environ Pollut 55:173–177

    Google Scholar 

  • Liberg P (1977) Agarose gel electrophoresis fractionation of serum proteins in adult cattle. Acta Vet Scand 18:335

    Google Scholar 

  • Lisiewicz J, Rucinska M (1990) Hematoxic and immunotoxic effects of nitrogen dioxide. Med Pracy 41(4):233–237

    Google Scholar 

  • Llacuna S, Gorriz A, Durfort M, Nadal J (1993a) Effects of air pollution in passerine birds and small mammals. Arch Environ Contam Toxicol 24:59–66

    Google Scholar 

  • Llacuna S, Gorriz A, Nadal J (1993b) Study on the diversity on bird population under conditions of atmospheric pollution from the Cercs coal-fired power plant (Northeast Spain). Hist Animalium 2:117–123

    Google Scholar 

  • Lowry OH, Rosenbrough N, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265

    CAS  PubMed  Google Scholar 

  • Meulenbelt J, Bree L Van, Dormans JA, Boink AB, Sangster B (1992) Biochemical and histological alterations in rats after acute nitrogen dioxide intoxication. Human Exp Toxicol 11:189–200

    Google Scholar 

  • Oguz K, Baskurt MD (1988) Acute hematologic and hemorheologic effects of sulfur dioxide inhalation. Arch Environ Health. 43(5):344–348

    Google Scholar 

  • Parpart AK, Lorenz PB, Parpart ER (1947) The osmotic resistance (fragility) of human red cells. J Clin Invest 26:636–640

    Google Scholar 

  • Peinado VI, Viscor G, Palomeque J (1992) Erythrocyte osmotic fragility in artyodactilids mammals: relationships with plasma osmolality and red cell dimensions. Comp Haem Int 2:45–50

    Google Scholar 

  • Peinado VI, Alfaro V, Palomeque J, Palacios L, Viscor G (1993) Erythrocyte osmotic resistance during acute hypothermia in awake unrestrained rats. Eur J Physiol 424:555–557

    Google Scholar 

  • Schalm OW, Jain NC, Carroll EJ (1986) The plasma proteins dysproteinemias, and immune deficiency disorders. In: Schalm's Veterinary Hematology. Lea & Febiger, Philadelphia, pp 940–989

    Google Scholar 

  • Try K (1980) Lineation of the osmotic fragility curve of erythrocytes. Scand J Haematol 24:157–161

    Google Scholar 

  • Viscor G, Palomeque J (1982) Method for determining the osmotic fragility curves of erythrocytes in birds. Lab Anim 16:48–50

    Google Scholar 

  • Yamaguchi K, Jürgens KD, Bartels H (1987) Oxygen transfer properties and dimensions of red blood cells in high-altitude camelids, dromedary camel and goat. J Comp Physiol (B)157:1–9

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorriz, A., Llacuna, S., Riera, M. et al. Effects of air pollution on hematological and plasma parameters in Apodemus sylvaticus and Mus musculus . Arch. Environ. Contam. Toxicol. 31, 153–158 (1996). https://doi.org/10.1007/BF00203920

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00203920

Keywords

Navigation