Abstract
Two cases of anaplastic large cell Ki-1 lymphoma involving bone as the most prominent and initial manifestation are reported. The first patient was a 20-year-old male who had back pain and incomplete paraparesis due to vertebral involvement. The second was a 14-year-old girl, whose first clinical signs were fever of unknown origin and sternal bone pain. Radiologically, skeletal lesions were lytic and destructive. Histopathologically, the tumour cells had pleomorphic bizarre nuclei and abundant basophilic cytoplasm. Immunohistochemically, Ki-1 (CD30) reactivity was strongly positive in both cases. Tumour cells were also CD3, CD4, epithelial membrane antigen and interleukin-2 receptor positive in the first case, and CD10, HLA-DR positive in the second case. The former tumour was considered to be of T-cell lineage and the latter of lymphoid progenitor cell origin. Radiation and chemotherapy were temporarily effective. However, both patients died 14 and 7 months after diagnosis, respectively, due to systemic lymph node involvement. These observations suggest that the prognosis for Ki-1 lymphoma involving bone is poorer than indicated in previous reports.
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References
Agnarsson BA, Kadin ME (1988) Ki-1 positive large cell lymphoma. A morphologic and immunologic study of 19 cases. Am J Surg Pathol 12:264–274
Beljaards RC, Kaudewitz P, Berti E, Gianotti R, Neumann C, Rosso R, Paulli M, Meijer CJLM, Willemze R (1993) Primary cutaneous CD30-positive large cell lymphoma: Definition of a new type of cutaneous lymphoma with a favorable prognosis. A European multicenter sudy of 47 patients. Cancer 71:2097–2104
Chan JKC, Ng CS, Hui PK, Leung WT, Sin VC, Lam TK, Chick KW, Lam WY (1991) Anaplastic large cell Ki-1 lymphoma of bone. Cancer 68:2186–2191
Chott A, Kaserer K, Augustin I, Veseley M, Heinz R, Oehlinger W, Hank W, Radaszkiewicz T (1990) Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases. Am J Surg Pathol 14:439–448
Delsol G, Al Saati T, Gatter KC, Gerdes J, Schwarting R, Caveriviere P, Rigal-Huguet F, Robert A, Stein H, Mason DY (1988) Coexpression of epithelial membrane antigen (EMA), Ki-1, and interleukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am J Pathol 130:59–70
Falini B, Binazzi R, Pileri S, Mori A, Bertoni F, Canino S, Fagioli M, Minelli O, Ciani C, Pellicioli P (1988) Large cell lymphoma of bone. A report of three cases of B-cell origin. Histopathology 12:177–190
Fujimoto J (1990) Malignant lymphoma of childhood. Pediatr Jpn 31:871–876
Fujimoto J, Hata J, Ishii E, Kiyokawa N, Tanaka S, Morikawa Y, Shimizu K, Hajikano H (1988) Ki-1 lymphomas in childhood: immunohistochemical analysis and the significance of epithelial membrane antigen (EMA) as a new marker. Virchows Arch [A] 412:307–314
Greer JP, Kinney MC, Collins RD, Slhany KE, Wolff SN, Hainsworth JD, Flexner JM, Stein RS (1991) Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma. J Clin Oncol 9:539–547
Kadin ME, Sako D, Berliner N, Franklin W, Woda B, Borowitz M, Ireland K, Schweid A, Herzog P, Lange B, Dorfman R (1986) Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy. Blood 68:1042–1049
Kanekura T, Setoyama M, Yotsumoto S, Nishi M, Tashiro M (1991) Anaplastic large cell lymphoma, so-called Ki-1 lymphoma: A report of a case of long course. J Dermatol 18:345–351
Koike K, Hanada T, Ono I, Nagai Y, Shin K, Mori N, Takita H (1989) Childhood Ki-1 lymphoma complicated with multiple bone destruction. Jpn J Clin Hematol 30:2008–2013
Laing RJ, Jakubowski J, Kunkler IH, Hancock BW (1992) Primary spinal presentation of non-Hodgkin's lymphoma. A reappraial of management and prognosis. Spine 17:117–120
Ostrowski ML, Unni K, Banks PM, Shives TC, Evans RG, O'Connell MJ, Taylor WF (1986) Malignant lymphoma of bone. Cancer 58:2646–2655
Penny RJ, Blaustein JC, Longtine JA, Pinkus GS (1991) Ki-1-positive large cell lymphomas, a heterogeneous group of neoplasms. Morphologic, immunophenotypic, genotypic, and clinical features of 24 cases. Cancer 68:362–373
Salhany KE, Collins RD, Greer JP, Kinney MC (1991) Long-term survival in Ki-1 lymphoma. Cancer 67:516–522
Stein H, Mason DY, Gerdes J, O'Connor N, Wainscoat J, Pallesen G, Gatter K, Falini B, Delsol G, Lemke H, Schwarting R, Lennert K (1985) The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood 66:848–858
Tashiro K, Kikuchi M, Takeshita M, Yoshida T, Ohshima K (1989) Clinicopathological study of Ki-1-positive lymphomas. Pathol Res Pract 185:461–467
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Ishizawa, M., Matsumoto, K., Kukuda, S. et al. Anaplastic large cell Ki-1 lymphoma with bone involvement: Report of two cases. Vichows Archiv A Pathol Anat 427, 105–110 (1995). https://doi.org/10.1007/BF00203745
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DOI: https://doi.org/10.1007/BF00203745