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Neural integration by short term potentiation

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Abstract

Neurophysiological studies in the oculomotor system suggest that an integrative operation is required in order to derive an eye position signal from a command signal which usually correlates with eye velocity. Several proposed models for a neural integrator are examined. All these models incorporate some form of positive feedback as a basic mechanism. Based on the performance of the models, we argue that such a scheme require extreme high precision in order to work properly. A new model based on potentiation phenomena in synaptic transmission is proposed and is shown to be free from the deficits of most previous models. The proposed model also accounts for various neural behaviors in a very natural way. A possible implementation of the model is also discussed in the context of the vestibulo-ocular reflex (VOR).

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References

  • Becker W, Klein HM (1973) Accuracy of saccadic eye movements and maintenance of eccentric eye position in the dark. Vision Res 13:1021–1034

    Google Scholar 

  • Cannon SC, Robinson DA, Shamma S (1983) A proposed neural network for the integrator of oculomotor system. Biol Cybern 49:127–136

    Google Scholar 

  • Cannon SC, Robinson DA (1985) An improved neural network model for neural integrator of the oculomotor system: more realistic neuron behavior. Biol Cybern. 53:93–108

    Google Scholar 

  • Castellucci VF, Kandel ER (1976) Presynaptic facilitation as a mechanism for behavioral sensitization inAplysia, Science 194:1176–1178

    Google Scholar 

  • Fukuta J, Highstein MS, Ito M (1972) Cerebellar inhibitory control of the vestibuloocular reflex investigated in rabbit IIIrd nucleus. Exp Brain Res 14:511–526

    Google Scholar 

  • Galiana HL, Outerbridge JS (1984) A bilateral model for central neural pathways in vestibuloocular reflex. J Neurophysiol 51:210–241

    Google Scholar 

  • Ito M (1984) The cerebellum and neural control. Raven Press, New York

    Google Scholar 

  • Ito M, Highsein SM, Fukuda F (1970) Cerebellar inhibition of vestibuloocular reflex in rabbit and cat and its blockage by picrotoxin. Brain Res 17:524–526

    Google Scholar 

  • Kammath BY, Keller EL (1976) A neurological integrator for the oculomotor control system. Math Biosci 30:341–352

    Google Scholar 

  • Keller EL (1974) Participation of the medial pontine reticular formation in monkey. J Neurophysiol 37:316–332

    Google Scholar 

  • King WM, Lisberger SG, Fuchs AF (1976) Responses of fibers in medial longitudinal fasiculus (mlf) of alert monkey during horizontal and vertical conjugated eye movements evoked by vestibular or visual stimuli. J Neurophysiol 39:1135–1149

    Google Scholar 

  • Lisberger SG, Miles FA (1980) Role of primate medial vestibular nucleus in long-term adaptive plasticity of vestibuloocular reflex. J Neurophysiol 43:1725–1745

    Google Scholar 

  • Magleby KL (1987) Synaptic transmission, facilitation, augmentation, potentiation, depression. Encyclopedia of Neuroscience. Birkhäuser, Boston Basel Stuttgart

    Google Scholar 

  • Magleby KL, Zengle JE (1982) Quantitative description of stimulation-induced changes in transmitter release at the frog neuromuscular junction. J Gen Physiol 80:613–638

    Google Scholar 

  • Oyster CW, Takahashi E, Collewijin H (1972) Direction-selective retinal ganglion cells and control of optokinetic nystagmus in the rabbit. Vision Res 12:183–193

    Google Scholar 

  • Racine RJ, Milgram NW (1983) Short-term potentiation phenomena in the rat limbic forebrain. Brain Res 260:201–216

    Google Scholar 

  • Racine RJ, Wilson DA, Gingell R, Sunderland D (1986) Long-term potentiation in the interpositus and vestibular nuclei in the rat. Exp Brain Res 63:158–162

    Google Scholar 

  • Rall W (1960) Membrane potential transients and membrane time constants of motorneurons. Exp Neurol 2:503–532

    Google Scholar 

  • Robinson DA (1974) The effect of cerebellectomy on the cat's vestibuloocular integrator. Brain Res 71:195–207

    Google Scholar 

  • Robinson DA (1981) The use of control system analysis in the neurophysiology of eye movements. Ann Rev Neurosci 4:463–503

    Google Scholar 

  • Robinson DA (1989) Integrating with neurons. Ann Rev Neurosci 12:33–45

    Google Scholar 

  • Skavenski AA, Robinson DA (1973) Role of abducens neurons in vestibuloocular reflex. J Neurophysiol 36:724–738

    Google Scholar 

  • Torre V, Poggio T (1978) A synaptic mechanism possibly underlying directional selectivity to motion. Proc R Soc London B 202:409–416

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Physiology, 6-255 MH Laboratory of Neurophysiology, University of Minnesota, 435 Delaware Street, S. E., 55455, Minneapolis, MN, USA

    L. Shen

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  1. L. Shen
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Shen, L. Neural integration by short term potentiation. Biol. Cybern. 61, 319–325 (1989). https://doi.org/10.1007/BF00203180

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  • DOI: https://doi.org/10.1007/BF00203180

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