Skip to main content
SpringerLink
Log in

Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma

  • Published:
Journal of Molecular Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

IL :

Interleukin

GM-CSF :

Granulocyte-macrophage colony-stimulating factor

CTL :

Cytotoxic T lymphocyte

NK :

Natural killer

LAK :

Lymphokine-activated killer

References

  • Blankenstein T, Li W, Müller W, Diamantstein T (1990) Retroviral interleukin-4 gene transfer into an interleukin-4 dependent cell line results in autocrine growth but not in tumorigenicity. Eur J Immunol 20:935–938

    Google Scholar 

  • Blankenstein T, Qin Z, Überla K, Müller W, Rosen H, Volk H-D, Diamantstein T (1991) Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med 173:1047–1052

    Google Scholar 

  • Böhm M, Möller P, Kalbfleisch U, Worm M, Czarnetzki BM, Schadendorf D (1994) Lysis of allogeneic and autologous melanoma cells by IL-7-induced lymphokine-activated killer cells. Br J Cancer 70:54–59

    Google Scholar 

  • Boon T, Coulie P, Marchand M, Weynants P, Wölfel T, Brichard V (1994) Genes coding for tumor rejection antigens: perspectives for specific immunotherapy. In: DeVita VT, Hellman S, Rosenber SA (eds) Important advances in oncology 1994. Lippincott, Philadelphia, pp 53–69

    Google Scholar 

  • Colombo MR, Gerrari G, Stoppacciaro A, et al (1991) Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo. J Exp Med 173:889–897

    Google Scholar 

  • Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC (1993) Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long lasting anti-tumor immunity. Proc Natl Acad Sci USA 90:3539–3543

    Google Scholar 

  • Gansbacher B, Zier K, Daniels B, Cronin K, Bannerji R und Gilboa E (1990) Interleukin-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med 172:1217–1224

    Google Scholar 

  • Gansbacher B, Bannerji R, Daniels B, et al (1990) Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res 50:7820–7825

    Google Scholar 

  • Ho VC, Sober AJ (1990) Therapy for cutaneous melanoma: an update. J Am Acad Dermatol 22:159–176

    Google Scholar 

  • Hock H, Dorsch M, Diamantstein T, Blankenstein T. (1991). Inter-leukin-7 induces CD4+ T cell dependent tumor rejection. J Exp Med 174:1291–1298

    Google Scholar 

  • Parkinson DR, Houghton AN, Hersey P, Borden EC (1992) Biologic therapy for melanoma: In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong SJ (eds) Cutaneous melanoma. Lippincott, pp 522–541

  • Rosenberg SA (1994) Gene Therapy of Cancer. In: DeVita VT, Hellman S, Rosenberg SA (eds) Important advances in oncology 1994. Lippincott, Philadelphia, pp 17–38

    Google Scholar 

  • Schadendorf D, Worm M, Czarnetzki BM (1993) Determination of granulocyte/macrophage-colony-stimulating factor secretion by human melanoma cells and its effects on human melanoma cell proliferation. J Cancer Res Clin Oncol 119:501–503

    Google Scholar 

  • Schadendorf D, Böhm M, Möller P, Grünewald T, Czarnetzki BM (1994) Interleukin-7 induces differential lymphokine-activated killer cell activity against human melanoma cells, keratinocytes, and endothelial cells. J Invest Dermatol 102:838–842

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Virchow-Klinik, Dermatologie, Humboldt Universität Berlin, Augustenburger Platz 1, D-13344, Berlin, Germany

    D. Schadendorf (principal investigator), B. M. Czarnetzki & B. Wittig (coinvestigators)

Authors
  1. D. Schadendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. M. Czarnetzki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Wittig
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schadendorf, D., Czarnetzki, B.M. & Wittig, B. Interleukin-7, interleukin-12, and GM-CSF gene transfer in patients with metastatic melanoma. J Mol Med 73, 473–477 (1995). https://doi.org/10.1007/BF00202266

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00202266

Keywords

Search

Navigation