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Epidermal T lymphocytes — ontogeny, features and function

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Conclusions

The murine epidermis contains a network of Thy-1+ dendritic T cells. These T cells arise from early fetal stem cells and differentiate in the fetal or neonatal thymic or epidermal microenvironment. Their lack of expression of CD5, CD4, and CD8 antigens, as well as their virtually exclusive expression of a CD3/TCR Vγ3/Vδ1 complex, distinguishes DETC from the bulk of peripheral T cells.

The early appearance of TCR γ/δ cells in ontogeny, the lack of expression of CD4 and CD8 antigens, and the relative paucity of γ and δ genes compared to α and β genes, indicates that γ/δ T cells provide a phylogenetically primitive, broadly acting, and poorly discriminating immunologic defense system. In this system, recognition of antigen is not restricted by classical MHC class I and class II antigens, but may occur in the context of relatively nonpolymorphic restricting elements, such as Qa [82], Tla [10] or CD1 [62]. This rather primitive immune system provided by DETC may serve to protect the epidermal integrity. Upon recognition of self proteins released following epidermal injury, DETC may become activated and assist in the removal of altered cells. In this limited fashion, the epidermis may be an independently competent immunologic system. However, the fact that the TCR repertoire of DETC does not allow for the recognition of antigenic peptides in conjunction with MHC moieties excludes the possibility that the diverse immune response elicited by topical contact with foreign antigens is mediated by DETC.

Whether this statement also applies to the human epidermis cannot be answered at the present time. Let us consider a few plausible concepts concerning derivation and function of human epidermal T cells. First, one could postulate that in early ontogeny, the human epidermis harbors a small, indigenous population of naive T lymphocytes with monomorphic TCR representing an analogue to murine DETC. These cells could function in a manner similar to that proposed for murine DETC. They may even persist into adult life, so far undetected because they would be outnumbered by immigrating polymorphic T cells from peripheral lymphoid organs. Second, it is conceivable that the human epidermis contains an indigenous population of naive T lymphocytes with a polymorphic TCR repertoire representing a phylogenetically advanced analogue to murine DETC. Although equipped with TCR allowing antigen recognition in the context of MHC, their density is probably too low to make them an effective host defense system against the multitude of environmental antigens presented by Langerhans cells. One could rather assume that they proliferate upon recognition of self antigens occurring in a perturbed epidermis. The autoreactivity of these cells may not necessarily be beneficial. Finally, the fact that the entry of circulating HECA-452+ memory cells into the skin is dependent upon the injury-induced ELAM-1 expression by endothelial cells of the dermal microvasculature could indicate that all T cells present in adult human epidermis are recruited upon alteration of the skin. Following this reasoning, the human epidermis should not be regarded as a complete, self-sustaining immunologic organ but rather as a homing site for and a target of lymphocytes antigenically sensitized in peripheral lymphoid organs.

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References

  1. Aberer W, Romani N, Elbe A, Stingl G (1986) Effects of physicochemical agents on murine epidermal Langerhans cells and Thy-1-positive dendritic epidermal cells. J Immunol 136: 1210

    Google Scholar 

  2. Allison JP, Havran WL (1991) The immunobiology of T cells with invariant γδ antigen receptors. Annu Rev Immunol 9: 679

    Google Scholar 

  3. Allison JP, Lanier LL (1987) Structure, function, and serology of the T-cell antigen receptor complex. Annu Rev Immunol 5: 503

    Google Scholar 

  4. Asarnow DM, Kuziel WA, Bonyhadi M, Tigelaar RE, Tucker PW, Allison JP (1988) Limited diversity of γδ antigen receptor genes of Thy-1+ dendritic epidermal cells. Cell 55: 837

    Google Scholar 

  5. Asarnow DM, Goodman T, LeFrancois L, Allison JP (1989) Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells. Nature 341: 60

    Google Scholar 

  6. Barker JNWN, Sarma V, Mitra RS, Dixit VM, Nickoloff BJ (1990) Marked synergism between tumor necrosis factor-α and Interferon-γ in regulation of keratinocyte-derived adhesion molecules and chemotactic factors. J Clin Invest 85: 605

    Google Scholar 

  7. Bergstresser PR, Tigelaar RE, Dees JH, Streilein JW (1983) Thy-1 antigen-bearing dendritic cells populate murine epidermis. J Invest Dermatol 81: 286

    Google Scholar 

  8. Bergstresser PR, Tigelaar RE, Steilein JW (1984) Thy-1 antigen-bearing dendritic cells in murine epidermis are derived from bone marrow precursors. J Invest Dermatol 83: 83

    Google Scholar 

  9. Bonneville M, Janeway CA Jr, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S (1988) Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 336: 479

    Google Scholar 

  10. Bonneville M, Ito K, Krecko EG, Itohara S, Kappes D, Ishida I, Kanagawa O, Janeway CA Jr, Murphy DB, Tonegawa S (1989) Recognition of a self major histocompatibility complex TL region product by γδ T-cell receptors. Proc Natl Acad Sci USA 86: 5928

    Google Scholar 

  11. Bonneville M, Itohara S, Krecko EG, Mombaerts P, Ishida I, Katsuki M, Berns A, Farr AG, Janeway CA Jr, Tonegawa S (1990) Transgenic mice demonstrate that epithelial homing of γ/δ T cells is determined by cell lineages independent of T cell receptor specificity. J Exp Med 171: 1015

    Google Scholar 

  12. Bonyhadi M, Weiss A, Tucker PW, Tigelaar RE, Allison JP (1987) Delta is the Cx-gene product in the γ/δ antigen receptor of dendritic epidermal cells. Nature 330: 574

    Google Scholar 

  13. Bos JD, Zonneveld I, Das PK, Krieg SR, Van der Loos CM, Kapsenberg ML (1987) The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 88: 569

    Google Scholar 

  14. Bos JD, Teunissen MBM, Cairo I, Krieg SR, Kapsenberg ML, Das PK, Borst J (1990) T-cell receptor γδ-bearing cells in normal human skin. J Invest Dermatol 94: 37

    Google Scholar 

  15. Breathnach SM, Katz SI (1984) Thy-1+ dendritic cells in murine epidermis are bone marrow-derived. J Invest Dermatol 83: 74

    Google Scholar 

  16. Carding SR, Kyes S, Jenkinson EJ, Kingston R, Bottomly K, Owen JJT, Hayday AC (1990) Developmentally regulated fetal thymic and extrathymic T-cell receptor γδ gene expression. Genes Dev 4: 1304

    Google Scholar 

  17. Caughman SW, Breathnach SM, Sharrow SO, Stephany DA, Katz SI (1986) Culture and characterization of murine dendritic Thy-1+ epidermal cells. J Invest Dermatol 86: 615

    Google Scholar 

  18. Cruz PD Jr, Nixon-Fulton J, Tigelaar RE, Bergstresser PR (1989) Disparate effects of in vitro low-dose UVB irradiation of intravenous immunization with purified epidermal cell subpopulations for the induction of contact hypersensitivity. J Invest Dermatol 92: 160

    Google Scholar 

  19. Davis MM, Bjorkman PJ (1988) T-cell antigen receptor genes and T-cell recognition. Nature 334: 395

    Google Scholar 

  20. Dupuy P, Heslan M, Fraitag S, Hercend T, Dubertret L, Bagot M (1990) T-cell receptor-γδ bearing lymphocytes in normal and inflammatory human skin. J Invest Dermatol 94: 764

    Google Scholar 

  21. Dustin ML, Singer KH, Tuck DT, Springer TA (1988) Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by Interferon γ and is mediated by intercellular adhesion molecule 1 (ICAM-1). J Exp Med 167: 1323

    Google Scholar 

  22. Elbe A, Tschachler E, Steiner G, Binder A, Wolff K, Stingl G (1989) Maturational steps of bone marrow-derived dendritic murine epidermal cells. Phenotypic and functional studies on Langerhans cells and Thy-1+ dendritic epidermal cells in the perinatal period. J Immunol 143: 2431

    Google Scholar 

  23. Ferrick DA, Sambhara SR, Ballhausen W, Iwamoto A, Pircher H, Walker CL, Yokoyama WM, Miller RG, Mak TW (1989) T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice. Cell 57: 483

    Google Scholar 

  24. Foster CA, Yokozeki H, Rappersberger K, Koning F, Volc-Platzer B, Rieger A, Coligan JE, Wolff K, Stingl G (1990) Human epidermal T cells predominantly belong to the lineage expressing α/β T cell receptor. J Exp Med 171: 997

    Google Scholar 

  25. Garman RD, Doherty PJ, Raulet DH (1986) Diversity, rearrangement, and expression of murine T cell gamma genes. Cell 45: 733

    Google Scholar 

  26. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB (1989) Human lymphocytes bearing T cell receptor γ/δ are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med 169: 1277

    Google Scholar 

  27. Groh V, Fabbi M, Hochstenbach F, Maziarz RT, Strominger JL (1989) Double-negative (CD4− CD8−) lymphocytes bearing T-cell receptor α and β chains in normal human skin. Proc Natl Acad USA 86: 5059

    Google Scholar 

  28. Havran WL, Allison JP (1988) Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335: 443

    Google Scholar 

  29. Havran WL, Allison JP (1990) Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors. Nature 344: 68

    Google Scholar 

  30. Havran WL, Poenie M, Tigelaar RE, Tsien RY, Allison JP (1989) Phenotypic and functional analysis of γδ T cell receptor-positive murine dendritic epidermal clones. J Immunol 142: 1422

    Google Scholar 

  31. Havran WL, Grell S, Duwe G, Kimura J, Wilson A, Kruisbeek AM, O'Brien RL, Born W, Tigelaar RE, Allison JP (1989) Limited diversity of T-cell receptor γ-chain expression of murine Thy-1+ dendritic epidermal cells revealed by Vγ3-specific monoclonal antibody. Proc Natl Acad Sci USA 86: 4185

    Google Scholar 

  32. Havran WL, Chien Y-H, Allison JP (1991) Recognition of self antigens by skin-derived T cells with invariant γδ antigen receptors. Science 252: 1430

    Google Scholar 

  33. Honjo M, Elbe A, Steiner G, Assmann I, Wolff K, Stingl G (1990) Thymus-independent generation of Thy-1+ epidermal cells from a pool of Thy-1− bone marrow precursors. J Invest Dermato 95: 562

    Google Scholar 

  34. Ikuta K, Kina T, MacNeil I, Uchida N, Peault B, Chien Y-H, Weissman IL (1990) A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62: 863

    Google Scholar 

  35. Ito K, Bonneville M, Takagaki Y, Nakanishi N, Kanagawa O, Krecko EG, Tonegawa S (1989) Different γδ T-cell receptors are expressed on thymocytes at different stages of development. Proc Natl Acad Sci USA 86: 631

    Google Scholar 

  36. Itohara S, Tonegawa S (1990) Selection of γδ T cells with canonical T-cell antigen receptors in fetal thymus. Proc Natl Acad Sci USA 87: 7935

    Google Scholar 

  37. Itohara S, Farr AG, Lafaille JJ, Bonneville M, Takagaki Y, Haas W, Tonegawa S (1990) Homing of a γδ thymocyte subset with homogenous T-cell receptors to mucosal epithelia. Nature 343: 754

    Google Scholar 

  38. Koning F, Stingl G, Yokoyama WM, Yamada H, Maloy WL, Tschachler E, Shevach EM, Coligan JE (1987) Identification of a T3-associated γδ T cell receptor on Thy-1+ dendritic epidermal cell lines. Science 236: 834

    Google Scholar 

  39. Koning F, Yokoyama WM, Maloy WL, Stingl G, McConnell TJ, Cohen DI, Shevach EM, Coligan JE (1988) Expression of Cγ4 T cell receptors and lack of isotype exclusion by dendritic epidermal T cell lines. J Immunol 141: 2057

    Google Scholar 

  40. Kuziel WA, Takashima A, Bonyhadi M, Bergstresser PR, Allison JP, Tigelaar RE, Tucker PW (1987) Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature 328: 263

    Google Scholar 

  41. Kyes S, Pao W, Hayday A (1991) Influence of site of expression on the fetal γδ T-cell receptor repertoire. Proc Natl Acad Sci USA 88: 7830

    Google Scholar 

  42. Lafaille JJ, DeCloux A, Bonneville M, Takagaki Y, Tonegawa S (1989) Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59: 859

    Google Scholar 

  43. Larsen CG, Anderson AO, Appella E, Oppenheim JJ, Matsushima K (1989) The neutrophil activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 243: 1464

    Google Scholar 

  44. Leibl H, Hutterer J, Korschan H, Schuler G, Tani M, Tschachler E, Romani N, Wolff K, Stingl G (1985) Expression of the Ly-5 alloantigenic system on epidermal cells. J Invest Dermatol 84: 91

    Google Scholar 

  45. Lewis JM, Tigelaar RE (1991) Recognition of an epidermal stress antigen by murine γ/δ dendritic epidermal T cells (DETC). J Invest Dermatol 96: 538A

  46. Luster AD, Ravetch JV (1987) Biochemical characterization of a 7-interferon-inducible cytokine (IP-10). J Exp Med 166: 1084

    Google Scholar 

  47. Marlin SD, Springer TA (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51: 813

    Article  CAS  PubMed  Google Scholar 

  48. McConnell TJ, Yokoyama WM, Kikuchi GE, Einhorn GP, Stingl G, Shevach EM, Coligan JE (1989) δ-chains of dendritic epidermal T cell receptors are diverse but pair with γ-chains in a restricted manner. J Immunol 142: 2924

    Google Scholar 

  49. Miyauchi S, Hashimoto K (1989) Thy-1+ dendritic epidermal cells undergo mitosis in vivo. J Invest Dermatol 93: 429

    Google Scholar 

  50. Miyauchi S, Hashimoto K, Miki Y (1991) Detection of in situ mitotic activity of dendritic epidermal T-cells by BrdU labeling. J Histochem Cytochem 39: 283

    Google Scholar 

  51. Nickoloff BJ, Lewinsohn DM, Butcher EC, Krensky AM, Clayberger C (1988) Recombinant gamma-interferon increases the binding of peripheral blood mononuclear leukocytes and a Leu-3+ T lymphocyte clone to cultured keratinocytes and to a malignant cutaneous squamous carcinoma cell line that is blocked by antibody against the LFA-1 molecule. J Invest Dermatol 90: 17

    Google Scholar 

  52. Nixon-Fulton JL, Bergstresser PR, Tigelaar RE (1986) Thy-1+ epidermal cells proliferate in response to concanavalin A and interleukin 2. J Immunol 136: 2776

    Google Scholar 

  53. Nixon-Fulton JL, Witte PL, Tigelaar RE, Bergstresser PR, Kumar V (1987) Lack of dendritic Thy-1+ epidermal cells in mice with severe combined immunodeficiency disease. J Immunol 138: 2902

    Google Scholar 

  54. Nixon-Fulton JL, Hackett J, Bergstresser PR, Kumar V, Tigelaar RE (1988) Phenotypic heterogeneity and cytotoxic activity of Con A and IL-2-stimulated cultures of mouse Thy-1+ epidermal cells. J Invest Dermatol 91: 62

    Google Scholar 

  55. Nixon-Fulton JL, Kuziel WA, Santerse B, Bergstresser PR, Tucker PW, Tigelaar RE (1988) Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression. J Immunol 141: 1897

    Google Scholar 

  56. Ogimoto M, Yoshikai Y, Matsuzaki G, Matsumoto K, Kishihara K, Nomoto K (1970) Expression of T cell receptor Vγ5 in the adult thymus of irradiated mice after transplantation with fetal liver cells. Eur J Immunol 20: 1965

    Google Scholar 

  57. Okamoto H, Kripke ML (1987) Effector and suppressor circuits of the immune response are activated in vivo by different mechanisms. Proc Natl Acad Sci USA 84: 3841

    Google Scholar 

  58. Okamoto H, Itoh K, Welsh E, Trial J, Platsoucas C, Bucana C, Kripke ML (1988) In vitro cytotoxic activity of interleukin 2-dependent murine Thy-1+ dendritic epidermal cell lines. J Leukoc Biol 43: 502

    Google Scholar 

  59. Payer E, Elbe A, Stingl G (1991) Circulating CD3+/T cell receptor Vγ3+ fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells. J Immunol 146: 2536

    Google Scholar 

  60. Picker LJ, Michie SA, Rott LS, Butcher EC (1990) A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites. Am J Pathol 136: 1053

    Google Scholar 

  61. Picker LJ, Kishimoto TK, Smith CW, Warnock RA, Butcher EC (1991) ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 349: 796

    Google Scholar 

  62. Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989) Recognition of cluster of differentiation 1 antigens by human CD4 cytolytic T lymphocytes. Nature 341: 447

    Google Scholar 

  63. Reardon C, Lefrancois L, Farr A, Kubo R, O'Brien R, Born W (1990) Expression of γ/δ T cell receptors on lymphocytes from the lactating mammary gland. J Exp Med 172: 1263

    Google Scholar 

  64. Romani N, Stingl G, Tschachler E, Witmer MD, Steinman RM, Shevach EM, Schuler G (1985) The Thy-1-bearing cell of murine epidermis. A distinctive leukocyte perhaps related to natural killer cells. J Exp Med 161: 1368

    Google Scholar 

  65. Romani N, Tschachler E, Schuler G, Aberer W, Ceredig R, Elbe A, Wolff K, Fritsch PO, Stingl G (1985) Morphological and phenotypical characterization of bone marrow-derived dendritic Thy-1-positive epidermal cells of the mouse. J Invest Dermatol 85: 91s

  66. Romani N, Schuler G, Fritsch P (1986) Ontogeny of Ia-positive and Thy-1-positive leukocytes of murine epidermis. J Invest Dermatol 86: 129

    Google Scholar 

  67. Sauder DN, Monick MM, Hunninghake GW (1985) Epidermal cell-derived thymocyte activating factor (ETAF) is a potent T-cell chemoattractant. J Invest Dermatol 85: 431

    Google Scholar 

  68. Shibagaki N, Tamaki K, Shimada S (1991) In-vivo administration of recombinant IL-2 increases the number of Thy-1+ dendritic epidermal cells. Br J Dermatol 125: 116

    Google Scholar 

  69. Shimizu Y, Shaw S, Graber N, Gopal TV, Horgan KJ, Van Seventer GA, Newman W (1991) Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature 349: 799

    Google Scholar 

  70. Shiohara T, Nagashima M (1988) Monoclonal antibody (MAb) to lymphocyte function associated antigen 1 (LFA-1) inhibits epidermotropic migration of T cells in vitro and in vivo. J Invest Dermatol 90: 608A

  71. Shiohara T, Moriya N, Gotoh C, Hayakawa J, Saizawa K, Yagita H, Nagashima M (1989) Differential expression of lymphocyte function-associated antigen 1 (LFA-1) on epidermotropic and non-epidermotropic T-cell clones. J Invest Dermatol 93: 804

    Google Scholar 

  72. Shiohara T, Moriya N, Gotoh C, Hayakawa J, Nagashima M, Saizawa K, Ishikawa H (1990) Loss of epidermal integrity by T cell-mediated attack induces long-term local resistance to subsequent attack. I. Induction of resistance correlates with increases in Thy-1+ epidermal cell numbers. J Exp Med 171: 1027

    Google Scholar 

  73. Sprecher E, Becker Y, Kraal G, Hall E, Harrison D, Shultz LD (1990) Effect of aging on epidermal dendritic cell populations in C57BL/6J mice. J Invest Dermatol 94: 247

    Google Scholar 

  74. Steiner G, Koning F, Elbe A, Tschachler E, Yokoyama WM, Shevach EM, Stingl G, Coligan JE (1988) Characterization of T cell receptors on resident murine dendritic epidermal T cells. Eur J Immunol 18: 1323

    Google Scholar 

  75. Stingl G, Gunter KC, Tschachler E, Yamada H, Lechler RI, Yokoyama WM, Steiner G, Germain RN, Shevach EM (1987) Thy-1+ dendritic epidermal cells belong to the T-cell lineage. Proc Natl Acad Sci USA 84: 2430

    Google Scholar 

  76. Stingl G, Koning F, Yamada H, Yokoyama WM, Tschachler E, Bluestone JA, Steiner G, Samelson LE, Lew AM, Coligan JE, Shevach EM (1987) Thy-1+ dendritic epidermal cells express T3 antigen and the T-cell receptor γ chain. Proc Natl Acad Sci USA 84: 4586

    Google Scholar 

  77. Sullivan S, Bergstresser PR, Tigelaar RE, Streilein JW (1986) Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. J Immunol 137: 2460

    Google Scholar 

  78. Takagaki Y, DeCloux A, Bonneville M, Tonegawa S (1989) Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes. Nature 339: 712

    Google Scholar 

  79. Takashima A, Nixon-Fulton JL, Bergstresser PR, Tigelaar RE (1988) Thy-1+ dendritic epidermal cells in mice: precursor frequency analysis and cloning of concanavalin A-reactive cells. J Invest Dermatol 90: 671

    Google Scholar 

  80. Tschachler E, Schuler G, Hutterer J, Leibl H, Wolff K, Stingl G (1983) Expression of Thy-1 antigen by murine epidermal cells. J Invest Dermatol 81: 282

    Google Scholar 

  81. Tschachler E, Steiner G, Yamada H, Elbe A, Wolff K, Stingl G (1989) Dendritic epidermal T cells: activation requirements and phenotypic characterization of proliferating cells. J Invest Dermatol 92: 763

    Google Scholar 

  82. Vidović D, Roglić M, McKune K, Guerder S, MacKay C, Dembić Z (1989) Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma. Nature 340: 646

    Google Scholar 

  83. Warner NL (1974) Membrane immunoglobulins and antigen receptors on B and T lymphocytes. Adv Immunol 19: 67

    Google Scholar 

  84. Welsh EA, Kripke ML (1990) Murine Thy-1+ dendritic epidermal cells induce immunologic tolerances in vivo. J Immunol 144: 883

    Google Scholar 

  85. Yamada H, Tschachler E, Steiner G, Wolff K, Stingl G (1986) Phenotypic and functional analysis of freshly separated and in vitro expanded Thy-1+ dendritic epidermal cells. J Invest Dermatol 86: 341A

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  1. Division of Cutaneous Immunobiology, Department of Dermatology I, University of Vienna Medical School, Vienna International Research Cooperation Center, Brunner Strasse 59, A-1235, Vienna, Austria

    Elisabeth Payer, Adelheid Elbe & Georg Stingl

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Payer, E., Elbe, A. & Stingl, G. Epidermal T lymphocytes — ontogeny, features and function. Springer Semin Immunopathol 13, 315–331 (1992). https://doi.org/10.1007/BF00200531

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