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Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells

VI. A brief review

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References

  • Andersson, T., Stejskal, V., Härfast, B.: An in vitro study of human lymphocyte cytotoxicity against mumps-virus-infected target cells. J. Immunol. 114, 237 (1975)

    Google Scholar 

  • Baines, M. G., Pross, H. F., Millar, K. G.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells IV. The suppressive effect of normal pregnancy. Amer. J. Obst. and Gyn. In Press (1977)

  • Bakács, T., Gergely, P., Cornain, S., Klein, E.: Characterization of human lymphocyte subpopulations for cytotoxicity against tumor-derived monolayer culture. Int. J. Cancer 19, 441 (1977a)

    Google Scholar 

  • Bakács, T., Gergely, P., Klein, E.: Characterization of cytotoxic human lymphocyte subpopulations. The role of Fc-receptor carrying cells. Submitted for publication (1977b)

  • Bakács, T., Steinitz, M., Gergely, P., Klein, E.: Technical aspects of human blood lymphocyte separation with special attention to their killing potential. Submitted for publication (1977c)

  • Baldwin, R. W.: In vitro assays of cell-mediated immunity to human solid tumors: Problems of quantitation, specificity, and interpretation. J. Natl. Cancer Inst. 55, 745 (1975)

    Google Scholar 

  • Bean, M. A., Bloom, B. R., Herberman, R. B., Old, L. J., Oettgen, H. F., Klein, G., Terry, W. D.: Cell-mediated cytotoxicity for bladder carcinoma: Evaluation of a workshop. Cancer Res. 35, 2902 (1975)

    Google Scholar 

  • Beer, A. E., Billingham, R. E.: Immunobiology of mammalian reproduction. Adv. Immunol. 14, 1 (1971)

    Google Scholar 

  • Behelak, Y., Richter, M.: Immunocompetent cells in man. III. The killer cell activity of normal circulating lymphocytes. Clin. Immunol. Immunopathol. 4, 286 (1975)

    Google Scholar 

  • Behelak, Y., Banerjee, D., Richter, M.: Immunocompetent cells in patients with malignant disease: I. The lack of naturally occurring killer cell activity in the unfractionated circulating lymphocytes from patients with chronic lymphocytic leukemia (CLL). Cancer 38, 2274 (1976)

    Google Scholar 

  • Bloom, E. T., Seeger, R. C.: Disease and non-disease-related cell-mediated cytotoxicity in humans. Cancer Res. 36, 1361 (1976)

    Google Scholar 

  • Brooks, C. G., Rees, R. C., Baldwin, R. W.: Studies on the micro-cytotoxicity test. I. Evidence that the effects of normal lymphoid cells on tumour cell growth in microtest plates may be caused by non-immunological modifications of the culture medium. Int. J. Cancer 18, 778 (1976)

    Google Scholar 

  • Chiba, Y., Dzierba, I. L., Morag, A., Orga, P. L.: Cell-mediated immune response to mumps virus infection in man. J. Immunol. 116, 12 (1976)

    Google Scholar 

  • Coombs, R. R. A., Daniel, M. R., Gurner, B. W., Kelus, A.: Recognition of the species of cell origin in culture by mixed agglutination. II. Use of heterophile (anti-Forssman) sera. Int. Arch. Allergy 19, 210 (1961)

    Google Scholar 

  • Dean, D. M., Pross, H. F., Kennedy, J. C.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. III. Stimulatory and inhibitory effects of ionizing radiation. Int. J. Radiation Oncol. Biol. Phys. In Press (1977)

  • De Vries, J. E., Rümke, Ph., Bernheim, J. L.: Cytotoxic lymphocytes in melanoma patients. Int. J. Cancer 9, 567 (1972)

    Google Scholar 

  • De Vries, J. E., Cornain, S., Rümke, P.: Cytotoxicity of non-T- versus T-lymphocytes from melanoma patients and healthy donors on short- and long-term cultured melanoma cells. Int. J. Cancer 14, 427 (1974)

    Google Scholar 

  • De Vries, J. E., Meyering, M., Van Dongen, A., Rümke, P.: The influence of different isolation procedures and the use of target cells from melanoma cell lines and short-term cultures of the nonspecific cytotoxic effects of lymphocytes from healthy donors. Int. J. Cancer 15, 391 (1975)

    Google Scholar 

  • De Vries, J., Rümke, P.: Tumour-associated lymphocyte cytotoxicity superimposed on “spontaneous” cytotoxicity in melanoma patients. Int. J. Cancer 17, 182 (1976)

    Google Scholar 

  • Doherty, P. C., Blanden, R. V., Zinkernagel, R. M.: Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: Implications for H-antigen diversity. Transplant. Rev. 29, 89 (1976)

    Google Scholar 

  • Dunn, T. B., Potter, M.: A transplantable mast cell neoplasm in the mouse. J. Natl. Cancer Inst. 18, 587 (1957)

    Google Scholar 

  • Friend, C., Patuleia, M. C., Nelson, J. B.: Antibiotic effect of tylosine on a mycoplasma contaminant in a tissue culture leukemia cell line. Proc. Soc. Exp. Biol. and Med. 121, 1009 (1966)

    Google Scholar 

  • Good, R. A.: Evaluation of the evidence for immune surveillance. In: Immune Surveillance. Smith, R. T., Landy, M. (eds.), p. 439. New York: Academic Press 1970

    Google Scholar 

  • Greenberg, S. B., Criswell, B. S., Cough, R. B.: Lymphocyte-mediated cytotoxicity against influenza virus-infected cells: An in vitro method. J. Immunol. 115, 601 (1975)

    Google Scholar 

  • Hamburger, R. N., Pious, D. A., Milles, S. E.: Antigenic specificities acquired from the growth medium by cells in tissue culture. Immunology 6, 439 (1963)

    Google Scholar 

  • Härfast, B., Andersson, T., Stejskal, V., Perlmann, P.: Interactions between human lymphocytes and paramyxovirus-infected cells: Adsorption and cytotoxicity. J. Immunol. 118, 1132 (1977)

    Google Scholar 

  • Hellström, K. E., Hellström, I.: Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv. Immunol. 18, 209 (1974)

    Google Scholar 

  • Heppner, G., Henry, E., Stolbach, L., Cummings, F., McDonough, E., Calabresi, P.: Problems in the clinical use of the microcytotoxicity assay for measuring cell-mediated immunity to tumor cells. Cancer Res. 35, 1931 (1975)

    Google Scholar 

  • Herberman, R., Gaylord, C. E. (Eds.): Conference and workshop on cellular immune reactions to human tumor-associated antigens. Natl. Cancer Inst. Monogr. 37 (1973)

  • Herberman, R. S., Oldham, R. K.: Problems associated with study of cell-mediated immunity to human tumors by microcytotoxicity assays. J. Natl. Cancer Inst. 55, 749 (1975)

    Google Scholar 

  • Herberman, R. B., Nunn, M. E., Lavrin, D. H.: Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. I. Distribution of reactivity and specificity. Int. J. Cancer 16, 216 (1975a)

    Google Scholar 

  • Herberman, R. B., Nunn, M. E., Lavrin, D. H.: Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int. J. Cancer 16, 230 (1975b)

    Google Scholar 

  • Hersey, P., Edwards, A., Edwards, J., Adams, E., Milton, G. W., Nelson, D. S.: Specificity of cell-mediated cytotoxicity against human melanoma lines: evidence for “non-specific” killing by activated T-cells. Int. J. Cancer 16, 173 (1975)

    Google Scholar 

  • Holm, G., Perlmann, P., Werner, B.: Phytohaemagglutinin-induced cytotoxic action of normal lymphoid cells in tissue culture. Nature 203, 841 (1964)

    Google Scholar 

  • Holtermann, O. A., Kjerassi, I., Lisafeld, B. A., Elias, E., Papermaster, B. W., Klein, E.: In vitro destruction of tumor cells by human monocytes. Proc. Soc. Exp. Biol. 147, 456 (1974)

    Google Scholar 

  • Hutt, L. M., Huang, Y. T., Dascomb, H. E., Pagano, J. S.: Enhanced destruction of lymphoid cell lines by peripheral blood leukocytes taken from patients with acute infectious mononucleosis. The J. of Immunol. 115, 243 (1975)

    Google Scholar 

  • Irie, R. F., Irie, K., Morton, D. L.: Natural antibody in human serum to a neo-antigen in human cultured cells grown in foetal bovine serum. J. Natl. Cancer Inst. 52, 1051 (1974)

    Google Scholar 

  • Irie, R. F., Irie, K., Morton, D. L.: Characteristics of heterologous membrane antigen (H.M. Ag) on cultural human cells. J. Natl. Cancer Inst. 53, 1545 (1975)

    Google Scholar 

  • Jondal, M.: Spontaneous lymphocyte-mediated cytotoxicity (SLMC) in vitro: Assay for, and removal of the effector cell. In: In Vitro Methods in Cell-Mediated and Tumor Immunity. Bloom, B., David, J. (Eds.), p. 263. San Francisco: Academic Press, 1976

    Google Scholar 

  • Jondal, M., Klein, G.: Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors. J. Exp. Med. 138, 1365 (1973)

    Google Scholar 

  • Jondal, M., Pross, H. F.: Surface markers on human B- and T-lymphocytes. VI. Cytotoxicity against cell lines as functional marker for lymphocyte subpopulations. Int. J. Cancer 15, 596 (1975)

    CAS  PubMed  Google Scholar 

  • Julius, M. H., Simpson, E., Herzenberg, L. A.: A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur. J. Immunol. 3, 645 (1973)

    Google Scholar 

  • Karpas, A.: A human haemic cell line capable of cellular and humoral killing of normal and malignant cells. Br. J. Cancer 35, 152 (1977)

    Google Scholar 

  • Kerbel, R. S., Blakeslee, D.: Rapid adsorption of a foetal calf serum component by mammalian cells in culture. Immunology 31, 881 (1976)

    Google Scholar 

  • Kiessling, R., Klein, E., Pross, H., Wigzell, H.: “Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur. J. Immunol. 5, 117 (1975)

    Google Scholar 

  • Kiessling, R., Petranyi, G., Karre, K., Jondal, M., Tracey, D., Wigzell, H.: Killer Cells: A functional comparison between natural immune T cell and antibody-dependent in vitro systems. J. Exp. Med. 143, 772 (1976)

    Google Scholar 

  • Kiuchi, M., Takasugi, M.: The nonselective cytotoxic cell (N cell). J. Natl. Cancer Inst. 56, 575 (1976)

    Google Scholar 

  • Klein, E., Ben Bassat, H., Neumann, H., Ralph, P., Zeuthen, J., Polliack, A., Vanky, F.: Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia. Int. J. Cancer 18, 421 (1976)

    Google Scholar 

  • Koide, Y., Takasugi, M.: Distinct target determinants on two lymphoblastoid lines derived from the same individual. J. Immunol. 117, 1197 (1976)

    Google Scholar 

  • Landazuri, M. O. de, Herberman, R. B.: Specificity of cellular immune reactivity to virus-induced tumors. Nature (New Biol.) 238, 18 (1973)

    Google Scholar 

  • Levin, A., Massey, R. J., Kruse, R., Schowitz, D., Deinhardt, F.: Reproducibility of lymphocytotoxicity and blocking using a 51Cr microcytotoxicity assay in breast cancer patients and normal controls. Fed. Proc. 34, 846 (1976)

    Google Scholar 

  • Liburd, E. M., Pasderka, V., Russell, A. S., Dossetor, J. B.: Fibroblast lysis by lymphocytes from normal persons and SLE patients on short-term cultures. Immunology 31, 767 (1976)

    Google Scholar 

  • Lozzio, C. B., Lozzio, B. B.: Cytotoxicity of a factor isolated from human spleen. J. Natl. Cancer Inst. 50, 535 (1973)

    Google Scholar 

  • Lozzio, C. B., Lozzio, B. B., Yang, W.-K., Ichiki, A. I., Bamberger, E. G.: Absence of thymus-derived lymphocyte markers in myelogenous leukemia (Ph'+) cell line K562. Cancer Res. 36, 4657 (1976)

    Google Scholar 

  • Lundgren, G., Zukoski, C. F., Möller, G.: Differential effects of human granulocytes and lymphocytes on human fibroblasts in vitro. Clin. Exp. Immunol. 3, 817 (1968)

    Google Scholar 

  • Matthews, N., MacLaurin, B. P.: “Spontaneous” cytolysis by normal human lymphocytes of Burkitt's lymphoma cells of the EB2 cell line. Aust. J. Exp. Biol. Med. Sci. 52, 655 (1974)

    Google Scholar 

  • Matthews, N., MacLaurin, B. P.: Spontaneous cytotoxic activity as a test of human lymphocyte function. Lancet. I, 581 (1975)

    Google Scholar 

  • McCoy, J. L., Herberman, R. B., Rosenberg, E. B., Donelly, F. C., Levine, P. H., Alford, C.: 51Chromium-release assay for cell-mediated cytotoxicity of human leukemia and lymphoic tissue-culture cells. Natl. Cancer Inst. Monogr. 37, 59 (1973)

    Google Scholar 

  • Mukherji, B., Vassos, D., Flowers, A., Binder, S. C., Nathanson, C.: Variables and specificity of in vitro lymphocyte-mediated cytotoxicity in human melanoma. Cancer Res. 35, 3721 (1975)

    Google Scholar 

  • Oldham, R. K., Siwarski, O., McCoy, J. L., Plata, E. J., Herberman, R. B.: Evaluation of a cell-mediated cytotoxicity assay utilizing 125Iododeoxyuridine labelled tissue culture target cells. Natl. Cancer Inst. Monogr. 37, 49 (1973)

    Google Scholar 

  • Oldham, R. K., Djeu, J. K., Cannon, G. B., Siwarski, D., Herberman, R. B.: Cellular microcytotoxicity in human tumor systems: Analysis of results. J. Natl. Cancer Inst. 55, 1305 (1975)

    Google Scholar 

  • Oldham, R. K., Dean, J. H., Cannon, G. B., Ortaldo, J. R., Dunston, G., Applebaum, F., McCoy, J. L., Djeu, J., Herberman, R. B.: Cryopreservation of human lymphocyte function as measured by in vitro assays. Int. J. Cancer. 18, 145 (1976)

    Google Scholar 

  • Olding, L. B., Jensen, F. C., Oldstone, M. B. A.: Pathogenesis of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogeneic reaction. J. Exp. Med. 141, 561 (1975)

    Google Scholar 

  • Ono, A., Amos, D. B., Koren, H. S.: Selective cellular natural killing against human leukaemic T cells and thymus. Nature 266, 546 (1977)

    Google Scholar 

  • O'Toole, C.: Standardization of microcytotoxicity assay for cell mediated immunity. Natl. Cancer Inst. Monogr. 37, 19 (1973)

    CAS  PubMed  Google Scholar 

  • Parkman, R., Rosen, F.: Identification of a subpopulation of lymphocytes in human peripheral blood cytotoxic to autologous fibroblasts. J. Exp. Med. 144, 1520 (1976)

    Google Scholar 

  • Pavie-Fischer, J., Kourilsky, F. M., Picard, F., Banzet, P., Puissant, A.: Cytotoxicity of lymphocytes from healthy subjects and from melanoma patients against cultured melanoma cells. Clin. Exp. Immunol. 21, 430 (1975)

    Google Scholar 

  • Peter, H. H., Kalden, J. R., Seeland, P., Diehl, V., Eckert, G.: Humoral and cellular immune reactions in vitro against allogeneic and autologous human melanoma cells. Clin. Exp. Immunol. 20, 193 (1975a)

    Google Scholar 

  • Peter, H. H., Pavie-Fischer, J., Fridman, W. H., Aubert, C., Cesarini, J.-P., Rougin, R., Kourilsky, K. M.: Cell-mediated cytotoxicity in vitro of human lymphocytes against a tissue culture melanoma cell line (IGR3). J. Immunol. 115, 539 (1975b)

    Google Scholar 

  • Peter, H. H., Eifes, R. F., Kalden, J. R.: Spontaneous cytotoxicity (CMC) of normal human lymphocytes against a human melanoma cell line: a phenomenon due to a lymphotoxin-like mediator. J. Immunol. 116, 342 (1976a)

    Google Scholar 

  • Peter, H. H., Knoop, F., Kalden, J. R.: Spontaneous and antibody-dependent cellular cytotoxicity in melanoma patients and healthy control persons. Z. Immunitätsforsch. 151, 263 (1976b)

    Google Scholar 

  • Peter, H. H., Pavie-Fischer, J., Kalden, J. R., Roubin, R., Cesarini, J. P., Kourilsky, F. M.: Isolation and immunological characterization of different lymphocyte populations from human peripheral blood with special emphasis on ‘null’-lymphocytes. INSERM 57, 213 (1976c)

    Google Scholar 

  • Petranyi, G., Ivanyi, P., Hollan, S. R.: Relations of HL-A and Rh systems to immune reactivity. Vox. Sang. (Basel) 26, 470 (1974)

    Google Scholar 

  • Pierce, G. E., DeVald, B. L.: Effects of human lymphocytes on cultured normal and malignant cells. Cancer Res. 35, 1830 (1975)

    Google Scholar 

  • Podleski, W. K.: Spontaneous lymphocyte-mediated cytotoxicity. Lancet II, 1315 (1975)

    Google Scholar 

  • Podleski, W. K.: Cytodestructive mechanisms provoked by lymphocytes. Am. J. Med. 61, 1 (1976)

    Google Scholar 

  • Pross, H. F., Jondal, M.: Cytotoxic lymphocytes from normal donors. A functional marker of human non-T lymphocytes. Clin. Exp. Immunol. 21, 226 (1975a)

    Google Scholar 

  • Pross, H. F., Jondal, M.: Spontaneous cytotoxic activity as a test of human lymphocyte function. Lancet 1, 335 (1975b)

    Google Scholar 

  • Pross, H. F., Baines, M. G.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. I. The effect of malignant disease. Int. J. Cancer 18, 593 (1976)

    Google Scholar 

  • Pross, H. F., Baines, M. G.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. VII. An assessment of normal donor variability. Manuscript in preparation (1977)

  • Pross, H. F., Baines, M. G., Jondal, M.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. II. Is the complement receptor necessarily present on the killer cells? Int. J. Cancer 20, 353 (1977a)

    Google Scholar 

  • Pross, H. F., Gupta, S., Good, R. A., Baines, M. G.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. VIII. The effect of immunodeficiency disease. Manuscript in preparation (1977b)

  • Pross, H. F., Luk, S., Baines, M. G.: Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. V. The role of serum derived heterologous membrane antigens. Int. J. Cancer. In Press (1977c)

  • Reedman, B. M., Klein, G.: Cellular localization of an Epstein-Barr virus (EBV)-associated complement fixing antigen in producer and non-producer lymphoblastoid cell lines. Int. J. Cancer 11, 499 (1973)

    Google Scholar 

  • Rosenberg, E. B., Herberman, R. B., Levine, P. H.: Lymhocyte cytotoxicity reactions to leukemia-associated antigens in identical twins. Int. J. Cancer 9, 648 (1972)

    Google Scholar 

  • Rosenberg, E. B., McCoy, J. L., Green, S. S., Donelly, F. C., Siwarski, D. F., Levine, P. H., Herberman, R. B.: Destruction of human lymphoid tissue-culture cell lines by human peripheral lymphocytes in 51Cr-release cellular cytotoxicity assays. J. Natl. Cancer Inst. 52, 345 (1974)

    Google Scholar 

  • Rygaard, J., Povlsen, C. O.: The mouse mutant nude does not develop spontaneous tumours. Acta. Pathol. Microbiol. Scand. Sect. B. 82, 99 (1974)

    Google Scholar 

  • Saksela, E., Imir, T., Makela, O.: Spontaneous, augmentable cell-mediated cytotoxicity with limited target cell specificity in human blood. Eur. J. Immunol. 7, 126 (1977)

    Google Scholar 

  • Sulit, H. L., Golub, S. H., Irie, R. F., Gupta, R. K., Grooms, G. A., Morton, D. L.: Human tumour cells grown in fetal calf serum and human serum: influences on the tests for lymphocyte cytotoxicity, serum blocking and serum arming effects. Int. J. Cancer 17, 461 (1976)

    Google Scholar 

  • Svedmyr, E., Jondal, M.: Cytotoxic effector cells specific for B cell lines transformed by Epstein-Barr virus are present in patients with infectious mononucleosis. Proc. Nat. Acad. Sci. (Wash.) 72, 1622 (1975)

    CAS  PubMed  Google Scholar 

  • Takasugi, M., Klein, E.: A microassay for cell-mediated immunity. Transplantation 9, 219 (1970)

    CAS  PubMed  Google Scholar 

  • Takasugi, M., Mickey, M. R., Terasaki, P. I.: Allogenic cell-mediated testing for human tumor antigens. Natl. Cancer Inst. Monogr. 35, 251 (1972)

    Google Scholar 

  • Takasugi, M., Mickey, M. R., Terasaki, P. I.: Quantitation of the microassay for cell-mediated immunity through electronic image analysis. Natl. Cancer Inst. Monogr. 37, 77 (1973a)

    Google Scholar 

  • Takasugi, M., Mickey, M. R., Terasaki, P. I.: Reactivity of lymphocytes from normal persons on cultured tumor cells. Cancer Res. 33, 2898 (1973b)

    Google Scholar 

  • Takasugi, M., Mickey, M. R., Terasaki, P. I.: Studies on specificity of cell-mediated immunity to human tumours. J. Natl. Cancer Inst. 53, 1527 (1974)

    CAS  PubMed  Google Scholar 

  • Takasugi, M., Akira, D., Kinoshita, K.: Granulocytes as effectors in cell-mediated cytotoxicity of adherent target cells. Cancer Res. 35, 2169 (1975)

    Google Scholar 

  • Takasugi, M., Mickey, M. R.: Interaction analysis of selective and nonselective cell-mediated cytotoxicity. J. Natl. Cancer Inst. 57, 255 (1976)

    Google Scholar 

  • Takasugi, M., Akira, D., Takasugi, J., Mickey, M. R.: Specificities in human natural cell-mediated cytotoxicity. J. Natl. Cancer Inst. 59, 69 (1977a)

    Google Scholar 

  • Takasugi, M., Koide, Y., Akira, D., Ramseyer, A.: Specificities in natural cell-mediated cytotoxicity by the cross-competition assay. Int. J. Cancer 19, 291 (1977b)

    Google Scholar 

  • Takasugi, M., Ramseyer, A., Takasugi, J.: Decline of natural nonselective cell-mediated cytotoxicity in patients with tumor progression. Cancer Res. 37, 413 (1977c)

    Google Scholar 

  • Valdimarsson, H., Agnarsdottir, G., Lachmann, P. I.: Measles virus receptors on human T lymphocytes. Nature 255, 554 (1975)

    Google Scholar 

  • Vose, B. M., Moore, M., Schofield, H., Dymock, I. W.: Leucocytotoxicity in malignant and non-malignant colonic diseases. Clin. Exp. Immunol. 22, 393 (1975)

    Google Scholar 

  • Vose, B. M., Moore, M.: Reactivity of peripheral blood leukocytes against human foetal cells. Eur. J. Cancer 12, 639 (1976)

    Google Scholar 

  • Vose, B. M., Moore, M.: Reactivity of peripheral blood leukocytes against human foetal cells. II. Cytotoxic potential of preparations enriched or depleted of different leukocyte populations. Int. J. Cancer 19, 34 (1977)

    Google Scholar 

  • West, W. H., Cannon, G. B., Kay, H. K., Bonnard, G. D., Herberman, R. B.: Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: Characterization of effector cells. J. Immunol. 118, 355 (1977)

    Google Scholar 

  • Wilson, A. B., Plantrose, D. N., Nagington, I., Park, I. R., Barry, R. D., Coombs, R. R. A.: Influenza A antigens on human lymphocytes in vitro and probably in vivo. Nature 259, 582 (1976)

    Google Scholar 

  • Wolfe, S. A., Tracey, D. E., Henney, C. S.: Induction of “natural killer” cells by BCG. Nature 262, 584 (1976)

    Google Scholar 

  • Yust, I., Smith, R. W., Wunderlick, J. R., Mann, D. L.: Temporary inhibition of antibody-dependent cell-mediated cytotoxicity by pretreatment of human attacking cells with ammonium chloride. J. Immunol. 116, 1170 (1976)

    Google Scholar 

  • Zielske, J. V., Golub, S. H.: Fetal calf serum-induced blastogenic and cytotoxic responses of human lymphocytes. Cancer Res. 36, 3842 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Queen's University, Kingston, Ontario, Canada

    Hugh F. Pross (Research Associate)

  2. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada

    Hugh F. Pross (Research Associate)

  3. Department of Obstetrics and Gynecology, Queen's University, Kingston, Ontario, Canada

    Malcolm G. Baines

  4. Ontario Cancer Treatment and Research Foundation, Canada

    Hugh F. Pross (Research Associate)

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  1. Hugh F. Pross
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  2. Malcolm G. Baines
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Pross, H.F., Baines, M.G. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. Cancer Immunol Immunother 3, 75–85 (1977). https://doi.org/10.1007/BF00200062

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