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Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris

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Summary

Growth of Meth-A tumor in CDF1 mice was inhibited significantly by injection of a hot water extract of a strain of Chlorella vulgaris (CE) into the tumor or into the subcutaneous tissue near the tumor. The augmentation of resistance by CE may require the participation of T cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. Mice treated with CE exhibited antigen-specific augmented resistance against rechallenge with tumor. Moreover, the antitumor effect of CE was comparable with that of Corynebacterium parvum, but its mechanism of effect might be different.

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Authors and Affiliations

  1. Department of Immunology, Medical Institute of Bioregulation, Kyushu University, 69, 3-1-1 Maidashi Higashi-Ku, 812, Fukuoka, Japan

    Kuniaki Tanaka, Fumiko Konishi, Kunisuke Himeno, Kazuto Taniguchi & Kikuo Nomoto

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  1. Kuniaki Tanaka
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  2. Fumiko Konishi
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  3. Kunisuke Himeno
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  4. Kazuto Taniguchi
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  5. Kikuo Nomoto
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Tanaka, K., Konishi, F., Himeno, K. et al. Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris . Cancer Immunol Immunother 17, 90–94 (1984). https://doi.org/10.1007/BF00200042

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  • DOI: https://doi.org/10.1007/BF00200042

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