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Human tumor-associated antigens identified by monoclonal antibodies

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Conclusions

Monoclonal antibodies have been obtained that are specific for cell surface antigens of human tumors. Some of these antigens are tissue type specific tumor antigens, most strongly expressed on tumors of the same histological type. The antigens identified by the monoclonal antibodies are primarily normal differentiation antigens that are expressed more strongly on neoplastic cells than on most normal adult cells. For several antigens, the higher degree of antigen expression on neoplastic cells appear to be adequate for diagnostic and therapeutic purposes. Future work in this area is likely to have far-reaching consequences for the clinical handling of human cancer patients.

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Authors and Affiliations

  1. Program in Tumor Immunology, Fred Hutchinson Cancer Research Center, 98104, Seattle, Washington, USA

    Karl Erik Hellström, Ingegerd Hellström & Joseph P. Brown

  2. Departments of Pathology and Microbiology/Immunology, University of Washington, 98195, Washington, USA

    Karl Erik Hellström, Ingegerd Hellström & Joseph P. Brown

Authors
  1. Karl Erik Hellström
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  2. Ingegerd Hellström
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  3. Joseph P. Brown
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Additional information

This work was supported by grants CA 14135, 19148, 19149, CA 25558, CA 27841 from the National Institutes of Health, and IM 241A from the American Cancer Society. The authors wish to acknowledge collaboration with Drs. M.-Y. Yeh, R. G. Woodbury, S. M. Larson, and K. Nishiyama

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Hellström, K.E., Hellström, I. & Brown, J.P. Human tumor-associated antigens identified by monoclonal antibodies. Springer Semin Immunopathol 5, 127–146 (1982). https://doi.org/10.1007/BF00199792

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