Skip to main content
Log in

Multiple dose toxicokinetic influence on the estrogenicity of 2,2′,4,4′,5,5′-hexachlorobiphenyl

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Astroff B, Safe S (1988) Comparative antiestrogenic activities of 2,3,7,8-TCDD and 6-methyl-1,3,8-trichloro-dibenzofuran in the female rat. Toxicol Appl Pharmacol 95:435–443.

    Google Scholar 

  • Bitman J, Cecil HC (1970) Estrogenic activity of DDT analogs and polychlorinated biphenyls. J Agr Food Chem 1:1108–1112.

    Google Scholar 

  • Brouwer A (1989) Inhibition of thyroid hormone transport in plasma of rats by polychlorinated biphenyls. Arch Toxicol Suppl 13: 440–445.

    Google Scholar 

  • Ecobichon DJ, Mackenzie DO (1974) The uterotropic activity of commercial and isomerically-pure chlorobiphenyls in the rats. Res Commun Chem Pathol Pharmacol 9:85–94.

    Google Scholar 

  • Hansen LG (1979) Selective accumulation and depletion of polychlorinated biphenyl components: food animal implications. Ann NY Acad Sci 320:238–246.

    Google Scholar 

  • Hansen LG (1987) Food chain modification of the composition and toxicity of polychlorinated biphenyl residues. Rev Environ Toxicol 3:149–212.

    Google Scholar 

  • Jansen HT, Cooke PS, Porcelli J, Liu T-C, Hansen LG (1993) Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and In vivo studies. Reprod Toxicol 7:237–248.

    Google Scholar 

  • Kaminsky LS, Kennedy MW, Adams SM, Guengerich FP (1981) Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P450. J Biochem 20:7379–7384.

    Google Scholar 

  • Korach KS, Sarver P, Chae K, McLachlan JA, Mckinney JD (1988) Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes. Mol Pharmacol 33:120–126.

    Google Scholar 

  • Krishnan V, Safe S (1993) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: Quantitative structure-activity relationships. Toxicol Appl Pharmacol 120:55–61.

    Google Scholar 

  • Kupfer D, Bulger WH (1982) Estrogenic actions of chlorinated hydrocarbons. In Effects of Chronic Exposures to Pesticides on Animal Systems. (JE Chambers, JD Yarbrough, Eds.), pp. 121–146. Raven Press, New York.

    Google Scholar 

  • Lowery OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275.

    CAS  PubMed  Google Scholar 

  • Morse DC, Koeter HBWM, Smits van Prooijen AE, Brouwer A (1992) Interference of polychlorinated biphenyls in thyroid hormone metabolism: Possible neurotoxic consequences in fetal and neonatal rats. Chemosphere 25:165–168.

    Google Scholar 

  • Ness DK, Schantz SL, Moshtaghian J, Hansen LG (1993) Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicol Lett 68:311–323.

    Google Scholar 

  • Pohl RA, Fouts RJ (1980) A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal Biochem 107:150–155.

    Google Scholar 

  • Sipes IG, Schnellmann RG (1987) Biotransformation of PCBs: Metabolic pathways and mechanisms. Environ Toxin Ser 1:97–110.

    Google Scholar 

  • Wolff MS, Toniolo PG, Lee EW, Rivera M, Dubin N (1993) Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst 85:648–652.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, M.H., Zhao, Y.D. & Hansen, L.G. Multiple dose toxicokinetic influence on the estrogenicity of 2,2′,4,4′,5,5′-hexachlorobiphenyl. Bull. Environ. Contam. Toxicol. 53, 583–590 (1994). https://doi.org/10.1007/BF00199030

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199030

Keywords

Navigation