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Apolipoprotein E phenotypes and hyperlipidemia in patients under maintenance hemodialysis

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Summary

Apolipoprotein E phenotypes and gene frequencies were determined in 560 patients receiving long-term hemodialysis. In addition, fasting plasma lipid- and apolipoprotein-concentrations were evaluated in 245 of these individuals. The distribution of the three major apolipoprotein E alleles (ε4, ε3, and ε2) and that of the six common apolipoprotein E phenotypes (E4/4, E3/3, E2/2, E4/2, E4/3, and E3/2) in the dialysis group was nearly identical to that of healthy controls. Patients with the apolipoprotein E phenotypes E2/2, E4/4 and E4/3 (comprising 24% of the whole group) had higher mean plasma cholesterol- and triglyceride-concentrations than those with the apolipoprotein E phenotypes E3/3 and E3/2 (72% of the whole group). Thus, the genetic polymorphism of apolipoprotein E may contribute to the individual risk of accelerated atherosclerosis in patients under maintenance hemodialysis.

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Authors and Affiliations

  1. Abteilung Innere Medizin I, Schwerpunkt Endokrinologie und Stoffwechsel, Universität Heidelberg, Bergheimer Strasse 58, W-6900, Heidelberg, Germany

    Giso Feussner, Stephan Wey, Jürgen Bommer, Dieter Deppermann & Reinhard Ziegler

  2. Medizinische Klinik, St. Markus Krankenhaus, Wilhelm-Eppstein-Strasse 2, W-6000, Frankfurt/M., Germany

    Peter Grüitzmacher

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  1. Giso Feussner
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  2. Stephan Wey
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  3. Jürgen Bommer
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  4. Dieter Deppermann
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  5. Peter Grüitzmacher
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  6. Reinhard Ziegler
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Feussner, G., Wey, S., Bommer, J. et al. Apolipoprotein E phenotypes and hyperlipidemia in patients under maintenance hemodialysis. Hum Genet 88, 307–312 (1992). https://doi.org/10.1007/BF00197265

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  • DOI: https://doi.org/10.1007/BF00197265

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