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Genetic analysis of susceptibility to Type 1 diabetes

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Conclusions

Allelic sequencing combined with comparative analyses of population-specific haplotypes have provided persuasive evidence that the Type 1 diabetes susceptibility determinants associated and linked to the MHC class II region are partly due to DQ allelic polymorphism. A central role for an immune response molecule in this disease is consistent with many of the features of Type 1 diabetes. Identification of autoantigens and cloning of pathogenic T cells will help elucidate the roles of class II alleles in disease. This and mapping of other genes both inside and outside the MHC will eventually lead to a way of preventing or at least decreasing beta cell destruction.

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  1. Nuffield Department of Surgery, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK

    J. A. Todd

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  1. J. A. Todd
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Todd, J.A. Genetic analysis of susceptibility to Type 1 diabetes. Springer Semin Immunopathol 14, 33–58 (1992). https://doi.org/10.1007/BF00197131

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