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Primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype

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Abstract

We report a rare case of primary hepatic lymphoma, Stage II disease, in a 48-year-old male who had a solitary hepatic tumour measuring 4×4.5×3 cm. The tumour showed a nodular growth pattern and lymphoepithelial lesions with bile ducts. Some neoplastic nodules had a non-neoplastic atrophic germinal centre and/or a thin mantle cell layer. Morphologically, the neoplastic cells were centrocyte-like cells or intermediate lymphocytes. They expressed L26(CD20)+/LN-1(CDw75)±/LN-2(CD74)+/cyclin D1− and had a monotypic immunoglobulin of cytoplasmic IgM (к) on paraffin sections. The neoplastic cells or neoplastic nodules expressed surface IgM+/surface IgD±/Leu-1(CD5)+/DRC-1+/alkaline phosphatase+/B1(CD20)+/B4(CD19)− on fresh frozen sections. We therefore diagnosed this case as primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. We confirm that it is difficult to differentiate extranodal marginal zone B-cell lymphoma (low grade B-cell lymphoma of mucosa-associated lymphoid tissue type; MALT lymphoma) and mantle cell lymphoma.

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Authors and Affiliations

  1. Department of Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    G. Ueda & T. Matsumoto

  2. Department of Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan

    K. Oka

  3. Department of Pathology and Clinical Laboratories, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan

    Y. Yatabe

  4. Department of Gastroenterology, Juntendo University School of Medicine, Bunkyo-ku, Japan

    K. Yamanaka, M. Suyama & J. Ariyama

  5. Department of Surgery, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan

    S. Futagawa

  6. Department of Pathology, Nagoya University School of Medicine, Nagoya, Aichi, Japan

    N. Mori

Authors
  1. G. Ueda
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  2. T. Matsumoto
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  3. K. Oka
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  4. Y. Yatabe
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  5. K. Yamanaka
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  6. M. Suyama
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  7. J. Ariyama
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  8. S. Futagawa
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  9. N. Mori
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Ueda, G., Matsumoto, T., Oka, K. et al. Primary hepatic marginal zone B-cell lymphoma with mantle cell lymphoma phenotype. Vichows Archiv A Pathol Anat 428, 311–314 (1996). https://doi.org/10.1007/BF00196707

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