Abstract
The aging basilar artery has some differences and some similarities when compared with the aorta and coronary arteries. As the non-necrotic intimal thickness increases over time, the number of smooth muscle cells reaches a steady state around age 25–30 years in the coronaries and aorta, but continues to increase in the basilar artery, even to 90 years of age. The numbers of cells per unit of tissue (the cell density) declines with age, and the patterns of decline are quantitatively similar in all three arterial segments. All arteries so far examined behave alike in showing that atheronecrosis emerges in those specimens that have sufficiently low density of intimal smooth muscle cells. These results identify low intimal cell density as a criterion for recognizing arteries that are prone to atheronecrosis. One possible explanation is that depopulation of the fibrotically thickened and aged intima, by spreading apart the smooth muscle cells with expanding matrix materials, could be the conditioning factor that brings about the intrusion of atheronecrosis.
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References
Baker AB, Iannone A (1959) Cerebrovascular disease. I. The large arteries of the circle of Willis. Neurology 9:321–332
Blumenthal HT, Handler FP, Blanche JO (1954) The histogenesis of arteriosclerosis of the larger cerebral arteries, with an analysis of the importance of mechanical factors. Am J Med 17:337–347
Dahl E (1976) Microscopic observations on cerebral arteries. In: Cervos-Navarro J, et al (eds) The cerebral vessel wall. Raven Press, New York, pp 15–21
Flora G, Dahl E, Nelson E (1967) Electron microscopic observations on human intracranial arteries. Arch Neurol 17:162–173
Guyton JR, Klemp KF (1993) Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks. Am J Pathol 143:1444–1457
Guyton JR, Klemp KF (1994) Development of the atherosclerotic core region. Chemical and ultrastructural analysis of microdissected atherosclerotic lesions from human aorta. Arterioscler Thromb 14:1305–1314
Hassler O (1962) Physiological intima cushions in the large cerebral arteries of young individuals. Acta Pathol Scand 55:19–26
Klassen AC, Sung JH, Stadlan EM (1968) Histological changes in cerebral arteries with increasing age. J Neuropathol Exp Neurol 27:607–623
Lillie RD, Fullmer HM (1976) Histopathologic techniquc and practice of histochemistry, 4th edn. McGraw-Hill, New York
Scott RF, Daoud AS, Wortman B, Morrison ES, Jarmolych J (1966) Proliferation and necrosis in coronary and cerebral arteries. J Atheroscl Res 6:499–509
Stary HC (1992) Composition and classification of human atherosclerotic lesions. Virchows Arch [A] 421:277–290
Stehbens WE (1960) Focal intimal proliferation in the cerebral arteries. Am J Pathol 36:289–294
Tracy RE, Kissling GE (1985) Age and fibroplasia as preconditions for atheronecrosis in the human thoracic aorta. Arch Pathol Lab Med 109:651–658
Tracy RE, Kissling GE (1987) Age and fibroplasia as preconditions for atheronecrosis in human coronary arteries. Arch Pathol Lab Med 111:957–963
Tracy RE, Kissling GE (1988) Comparison of human populations for histologica features of atherosclerosis. Arch Pathol Lab Med 112:1056–1065
Tracy RE, Kissling GE, Malcom GT, Devaney K (1987) Sequestration hypothesis of atherosclerosis. Virchows Arch [A] 411:425–434
Tracy RE, Kissling GE, Gandia M, Reynolds C (1989) Spatial dispersion of stainable lipid in frozen sections of human aorta. Virchows Arch [A] 415:39–49
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Tracy, R.E. Declining density of intimal smooth muscle cells and age as preconditions for atheronecrosis in the basilar artery. Vichows Archiv A Pathol Anat 427, 131–138 (1995). https://doi.org/10.1007/BF00196517
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DOI: https://doi.org/10.1007/BF00196517