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Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-α4 antibody in adjuvant arthritis

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Conclusions

The current treatment of RA does not provide acceptable control of the inflammatory process due to either the onset of adverse effects or the lack of efficacy. RA is a T-cell mediated process, in which activated T cells must migrate through the blood vessels to reach the synovium. Anti-adhesion therapies designed to block the interaction of T cells with activated endothelial cells could be of great interest to control the disease. Flow cytometry analysis, immunohistochemical and functional studies cell adhesion in vitro have shown that the interaction between VLA-4 on T cells and VCAM-1 on endothelial cells could play a relevant role in the onset and perpetuation of RA. Here we show that the treatment with HP2/1, an mAb directed against α4 subunit of VLA-4, prevents adjuvant arthritis in Lewis rats. Data suggest that treatment with anti-α4 antibodies could be of value in RA.

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Authors and Affiliations

  1. Servicio de Reumatología, Hospital Puerta de Hierro, c/San Martín de Porres 4, E-28035, Madrid, Spain

    Carmen Barbadillo, Juan Mulero & Jose L. Andreu

  2. Immunology Section, Hospital de la Princesa, Madrid, Spain

    Alicia G-Arroyo & Francisco Sánchez-Madrid

  3. Pathology Department, Hospital Puerta de Hierro, Madrid, Spain

    Clara Salas

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  1. Carmen Barbadillo
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  2. Alicia G-Arroyo
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  4. Juan Mulero
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  5. Francisco Sánchez-Madrid
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Barbadillo, C., G-Arroyo, A., Salas, C. et al. Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-α4 antibody in adjuvant arthritis. Springer Semin Immunopathol 16, 427–436 (1995). https://doi.org/10.1007/BF00196098

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