Skip to main content
SpringerLink
Log in

Correlation of electroretinographic and fluorescein angiographic findings in unilateral central retinal vein obstruction

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

• Background: In central retinal vein obstruction (CRVO), electroretinogram (ERG) abnormalities and extensive retinal capillary dropout (CD) in the fluorescein angiogram (FA) are good indicators of retinal ischemia. We retrospectively studied patients with unilateral CRVO and compared the ERG and FA results • Methods: Single white flash ERG, photopic ERG, scotopic ERG and flicker ERG were recordered in 30 cases of unilateral CRVO. We analyzed the correlation between the ERG results and the presence/absence of extensive CD • Results: The ERG b/a-wave amplitude ratios, photopic and scotopic b-wave amplitudes, and flicker amplitudes were significantly smaller (P<0.05) in eyes with extensive CD (n=12, 40%), than in eyes without (n=18, 60%). When the photopic or scotopic b-wave amplitudes were normal or supernormal, extensive CD on FA was absent in all eyes. When the b/a-wave ratios were ≥ 1.0 or when the b-wave amplitudes with white flash or flicker amplitudes were normal or supernormal, extensive CD was present in less than 32% of eyes • Conclusion: These results suggest that the ERG results, especially the b/awave amplitude ratio, are significantly correlated with the presence/absence of CD on FA in CRVO.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bresnick GH, Wis M (1988) Following up patients with central retinal vein occlusion. Arch Ophthalmol 106:324–326

    Google Scholar 

  2. Breton ME, Quinn GE, Keene SS, Dahmen JC, Brucker AJ (1989) Electroretinogram parameters at presentation as predictors of rubeosis in central retinal vein occlusion patients. Ophthalmology 96:1343–1352

    Google Scholar 

  3. Hayreh SS (1976) So-called ‘central retinal vein occlusion’. I. Pathogenesis, terminology, clinical features. Ophthalmologica 172:1–13

    Google Scholar 

  4. Hayreh SS (1983) Classification of central retinal vein occlusion. Ophthalmology 90:458–474

    Google Scholar 

  5. Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RE (1983) Ocular neovascularization with retinal vascular occlusion. III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology 90:488–506

    Google Scholar 

  6. Hayreh SS, Klugman MR, Podhajsky P, Kolder HE (1989) Electroretinography in central retinal vein occlusion. Correlation of electroretinographic changes with pupillary abnormalities. Graefe's Arch Clin Exp Ophthalmol 227:549–561

    Google Scholar 

  7. Hayreh SS, Klugman MR, Beri M, Kimura AE, Podhajsky P (1990) Differentiation of ischemic from nonischemic central retinal vein occlusion during the early acute phase. Graefe's Arch Clin Exp Ophthalmol 228:201–217

    Google Scholar 

  8. Johnson MA, Marcus S, Elman MJ, McPhee TJ (1988) Neovascularization in central retinal vein occlusion. Electroretinographic findings. Arch Ophthalmol 106:348–352

    Google Scholar 

  9. Kaye SB, Harding SP (1988) Early electroretinography in unilateral central retinal vein occlusion as a predictor of rubeosis iridis. Arch Ophthalmol 106:353–356

    Google Scholar 

  10. Laatikainen L, Kohner EM (1976) Fluorescein angiography and its prognostic significance in central retinal vein occlusion. Br J Ophthalmol 60:411–427

    Google Scholar 

  11. Laatikainen EM, Kohner M, Khoury D, Blach K (1977) Panretinal photocoagulation in central retinal vein occlusion: a randomised contralled clinical study. Br J Ophthalmol 61:741–753

    Google Scholar 

  12. Magargal LE, Brown G, Augsburger JJ, Parrish RK II (1981) Neovascular glaucoma following central retinal vein obstruction. Ophthalmology 88:1095–1101

    Google Scholar 

  13. Magargal LE, Brown G, Augsburger JJ, Donoso LA (1982) Efficacy of panretinal photocoagulation in preventing neovascular glaucoma following ischemic central retinal vein obstruction. Ophthalmology 89:780–784

    Google Scholar 

  14. Matsui Y, Katsumi O, McMeel JW, Hirose T (1994) Prognostic value of electroretinogram (ERG) in central retinal vein obstruction (CRVO). Graefe's Arch Clin Exp Ophthalmol 75–81

  15. Peterson H (1968) The normal b-potential in the single-flash clinical electroretinogram. Acta Ophthalmol [Suppl] 99:5–77

    Google Scholar 

  16. Sabates R, Hirose T, McMeel JW (1983) Electroretinography in the prognosis and classification of central retinal vein occlusion. Arch Ophthalmol 101:232–235

    Google Scholar 

  17. Sakaue H, Katsumi O, Hirose T (1989) Electroretinographic findings in fellow eyes of patients with central retinal vein occlusion. Arch Ophthalmol 107:1459–1462

    Google Scholar 

  18. Welch JC, Augsburger JJ (1987) Assessment of angiographic retinal capillary nonperfusion in central retinal vein occlusion. Am J Ophthalmol 103:761–766

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinical Research Unit, Schepens Eye Research Institute, Boston, Massachusetts, USA

    Yoshie Matsui, Osamu Katsumi, Mehul C. Mehta & Tatsuo Hirose

  2. Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

    Osamu Katsumi, Mehul C. Mehta & Tatsuo Hirose

  3. Retina Associates, Boston, Massachusetts, USA

    Osamu Katsumi, Mehul C. Mehta & Tatsuo Hirose

  4. Department of Ophthalmology, Faculty of Medicine, Kyoto University, Kyoto, Japan

    Yoshie Matsui

  5. Department of Ophthalmology, Saga Medical School, 849, Nabeshima, Saga, Japan

    Yoshie Matsui

Authors
  1. Yoshie Matsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Osamu Katsumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mehul C. Mehta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tatsuo Hirose
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsui, Y., Katsumi, O., Mehta, M.C. et al. Correlation of electroretinographic and fluorescein angiographic findings in unilateral central retinal vein obstruction. Graefe's Arch Clin Exp Ophthalmol 232, 449–457 (1994). https://doi.org/10.1007/BF00195353

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00195353

Keywords

Search

Navigation