Abstract
In a double-blind, double-dummy randomized controlled clinical trial, the onset and duration of the analgesic effect of dipyrone, 1 or 2 g, and diclofenac sodium, 75 mg, by either the i.m. or the i.v. route were compared in 293 patients (aged 18–70 years) with acute renal colic. A level of ≥ 50 mm on the 100-mm visual analogue scale was required for inclusion in the study. Patients were randomly allocated to six treatment groups, receiving dipyrone 1 g i.m., dipyrone 1 g i.v., dipyrone 2 g i.m., dipyrone 2 g i.v., diclofenac sodium 75 mg i.m.; and diclofenac sodium 75 mg i.v, respectively. Evaluations were performed at 10, 20, 30, and 60 min and 2, 4, and 6 h after treatment (time 0). Primary efficacy end points included course of pain, total pain, percentage of patients with a pain improvement of 50% or more at each evaluation time, pain intensity evaluated by the investigator on a 0–3 scale, and differences in pain intensity. The analgesic response was more marked and prolonged among patients receiving dipyrone 2 g i.m. or dipyrone 2 g i.v. There were no significant differences between dipyrone 1 g and diclofenac sodium 75 mg, by either the i.m. or the i.v. route. All treatment regimens were well tolerated.
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Littlejohns DW, Vere DW (1981) The clinical assessment of analgesic drugs. Br J Clin Pharmacol 11:319–332
Hetherigton JW, Philip NH (1986) Diclofenac sodium versus pethidine in acute renal colic. BMJ 292:237–238
Lundstam S, Wahlander L, Leissner KH, Kral JG (1982) Prostaglandin-synthetase inhibition with diclofenac sodium in treatment of renal colic: comparison with the use of a narcotic analgesic. Lancet I:1096–1097
Lehonen T, Kellokumpu I, Perni J, Sarsilla O (1983) Intravenous indomethacin in the treatment of ureteric colic. Ann Clin Res 15:197–199
Arellano F, Sacristan JA (1990) Metamizole: reassessment of its therapeutic role. Eur J Clin Pharmacol 38:617–619
Lloret J, Muñoz J, Monmany J, Puig X, Bonastre M, Brau J, Sola J, Domingo P, Francesc J (1987) Treatment of renal colic with dipyrone. Curr Ther Res 42:1119–1128
Collaborative Group of the Spanish Society of Clinical Pharmacology (1991) Comparative study of the efficacy of dipyrone, diclofenac sodium and pethidine in acute renal colic. Eur J Clin Pharmacol 40:543–546
Muriel C, Ortiz P, and the Cooperative Study Group (1993) Efficacy of two different intramuscular doses of dipyrone in acute renal colic. Methods Find Exp Clin Pharmacol 15:465–469
Miralles R, Camí J, Torné J, Garcés JM, Badenas JM (1987) Diclofenac versus dipyrone in acute renal colic: a double-blind controlled trial. Eur J Clin Pharmacol 33:527–528
Joyce CRB, Zusthi DW, Hrubes V, Mason RM (1975) Comparison of fixed interval and visual analogue scales for rating chronic pain. Eur J Clin Pharmacol 8:415–420
Huskisson EC (1974) Measurement of pain. Lancet II:1127–1131
Wallenstein SL (1985) Scaling clinical pain and pain relief. In: Bromm B (ed). Pain measurement in man. Elsevier, Amsterdam, pp 389–396
Sriwatanakul K, Kelvie W, Lasagna L, Calimlim JF, Weis OF, Metha G (1983) Studies with different types of visual analog scales for measurement of pain. Clin Pharmacol Ther 34:234–239
Babej-Dolle R, Freytag GS, Eckmeyer J, Zerle G, Schinzel S, Schmieder G, Stankov (1994) Parenteral dipyrone versus diclofenac and placebo in patients with acute lumbago or sciatic pain: randomized observer-blind multicenter study. Int J Clin Pharmacol Ther 32:204–209
International Agranulocytosis and Aplastic Anemia Study (1986) Risk of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics JAMA 256:1749–1757
Laporte JR, Carné X, Vidal X, Moreno V, Juan J (1991) Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Lancet 337:85–89
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Muriel-Villoria, C., Zungri-Telo, E., Díaz-Curiel, M. et al. Comparison of the onset and duration of the analgesic effect of dipyrone, 1 or 2 g, by the intramuscular or intravenous route, in acute renal colic. Eur J Clin Pharmacol 48, 103–107 (1995). https://doi.org/10.1007/BF00192733
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DOI: https://doi.org/10.1007/BF00192733