Summary
The ultrastructural appearance of two chondroblastoma were examined by scanning and transmission electron microscopy. The polygonal basal cells, with a scanty pericellular matrix, show a poorly developed endoplasmic reticulum and many Golgi bodies. The highly differentiated chondroid cells are assembled in isogenous clusters and show intracytoplasmic inclusions of glycogen and lipids, numerous mitochondria and superficial secretion vesicles arising from a well developed rough endoplasmic reticulum. Clusters of crystals, in close contact with the matrix collagen fibres, are found near to the tumour cells. These ultrastructural characteristics, together with the basal undifferentiated cells that proliferate and differentiate into cartilaginous tissue, distinguish this neoplasm from chondroma, mesenchymal chondrosarcoma and chondromyxoid fibroma and confirm its chondroid origin.
Résumé
Les auteurs ont comparé les aspects ultrastructuraux de deux chondroblastomes, au microscope électronique à balayage et au microscope électronique à transmission, afin d'évaluer l'histogénèse de la lésion. Les cellules basales, polyédriques et amassées, avec une matrice péricellulaire peu abondante, présentent un réticulum endoplasmique peu développé et des systèmes de Golgi souvent dilatés et multiples. Les cellules qui présentent la différenciation chondroîde la plus marquée sont réunies dans des groupes isogènes, montrant des inclusions de glycogène et de lipides dans le cytoplasme, de nombreuses mitochondries renflées et, en surface, des vésicules de sécrétion provenant d'un réticulum endoplasmique bien développé. On observe, tout prés de la cellule tumorale, des bouquets de cristaux en contact direct avec les fibres collagènes de la matrice. La présence de cellules basales indifférenciées qui prolifèrent et se différencient en tissu cartilagineux distingue cette néoplasie des autres (chondrome, chondrosarcome mésenchymal et fibrome chondromyxoïde) et permet de la classer parmi les lésions d'origine chondroïde.
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Fadda, M., Manunta, A., Rinonapoli, G. et al. Ultrastructural appearance of chondroblastoma. International Orthopaedics 18, 389–392 (1994). https://doi.org/10.1007/BF00187088
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DOI: https://doi.org/10.1007/BF00187088