Summary
The purpose of this study was to investigate sufficient conditions for the development of long-lasting otitis media with effusion (OME) without any organic obstruction of the eustachian tube. Three experimental conditions were employed using 20 adult cats (27 ears). Only tubal ventilatory dysfunction with transection of the tensor veli palatini muscle and excision of the pterygoid hamulus resulted in a small incidence of OME (7.1%), which lasted for 5 weeks. Instillation of Escherichia coli endotoxin into the middle ears formed only a transient OME in 50% of the animals. Combination of these two procedures brought a high incidence of OME (85.7%), most of which lasted for more than 8 weeks. These studies showed that tubal ventilatory dysfunction alone was not a sufficient condition for the development of OME but was important for prolongation of the pathological state of OME. The production of inflammatory exudate was considered to be a trigger for the formation of OME.
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References
Bernstein JM, Praino MD, Neter E (1980) Detection of endotoxin in ear specimens from patients with chronic otitis media by means of the limulus amebocyte lysate test. Can J Microbiol 26:546–548
Bluestone CD, Paradise JL, Beery QC (1972) Symposium on prophylaxis and treatment of middle ear effusions. IV. Physiology of the eustachian tube in the pathogenesis and management of middle ear effusions. Laryngoscope 82:1654–1670
Cantekin EI, Doyle WJ, Phillips DC, Bluestone CD (1980) Gas absorption in the middle ear. Ann Otol Rhinol Laryngol 89[Suppl 68]:71–75
Cantekin EI, Phillips DC, Doyle WJ, Bluestone CD, Kimes KK (1980) Effect of surgical alterations of the tensor veli palatini muscle on eustachian tube function. Ann Otol Rhinol Laryngol 89[Suppl 68]:47–53
DeMaria TF, Briggs BR, Lim DJ, Okazaki N (1984) Experimental otitis media with effusion following middle ear inoculation of nonviable H. influenzae. Ann Otol Rhinol Laryngol 93:52–56
Falk B (1982) Sniff-induced negative middle ear pressure: study of a consecutive series of children with otitis media with effusion. Am J Otolaryngol 3:155–162
Flisburg K, Ingelstedt S, Ortegren U (1963) On middle ear pressure. Acta Otolaryngol [Suppl] (Stockh) 182:43–56
Hayashi M, Takahashi H, Honjo I (1986) Effect of myringotomy upon otitis media with effusion (in Japanese). Otorhinolaryngol Tokyo 29:663–665
Kokko E (1974) Chronic secretory otitis media in children: a clinical study. Acta Otolaryngol [Suppl] (Stockh) 327:1–44
Lim DJ, Hussl B (1970) Tympanic mucosa after tubal obstruction. Arch Otolaryngol 91:585–593
Murphy D (1979) Negative pressure in the middle ear by ciliary propulsion of mucus through the eustachian tube. Laryngoscope 89:954–961
Proud GO, Odoi H (1970) Effects of eustachian tube ligation. Ann Otol Rhinol Laryngol 79:30–41
Proud GO, Odoi H, Toledo PS (1971) Bullar pressure changes in eustachian tube dysfunction. Ann Otol Rhinol Laryngol 80:835–837
Sadé J (1979) Secretory otitis media and its sequelae. Churchill Livingstone, New York
Sadé J, Carr CD, Senturia BH (1959) Middle ear effusions produced experimentally in dogs. I. Microscopic and bacteriologic findings. Ann Otol Rhinol Laryngol 68:1017–1027
Senturia BH, Gessert CF, Carr CD (1958) Studies concerned with tubotympanitis. Ann Otol Rhinol Laryngol 66:440–467
Senturia BH, Carr CD, Ahlvin RC (1962) Middle ear effusions: pathologic changes of the mucoperiosteum in the experimental animal. Ann Otol Rhinol Laryngol 71:632–647
Takahashi H, Hayashi M, Kurata K, Honjo I (1986) Eustachian tube function in cases of otitis media with effusion (in Japanese). Pract Otol (Kyoto) 79:1589–1597
Takahashi H, Hayashi M, Honjo I (1987) Negative middle ear pressure induced by excretory function of eustachian tube (in Japanese). Otorhinolaryngol Tokyo 30:203–206
Takasaka T, Shibahara Y, Hozawa K, Takeyama M, Kaku Y, Hara A, Shibuya M, Kikuchi T, Kawamoto K (1984) Histopathological analyses of experimentally induced otitis media with effusion (in Japanese). J Otolaryngol Jpn 87:688–692
Tos M, Wiederhold M, Larsen P (1984) Experimental longterm tubal occlusion in cats: a quantitative histopathological study. Acta Otolaryngol (Stockh) 97:580–592
Veltri RW, Sprinkle PM (1976) Secretory otitis media: an immune complex disease. Ann Otol Rhinol Laryngol 85 [Suppl 25]:135–139
Zaufal E (1870) Über das Vorkommen seröser Flüssigkeit in der Paukenhöhle (Otitis Media Serosa). Arch Ohrenheilkd 5:38–81
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Takahashi, H., Fujita, A., Lee, S.H. et al. Experimental conditions for the development of persistent otitis media with effusion. Eur Arch Otorhinolaryngol 247, 89–92 (1990). https://doi.org/10.1007/BF00183174
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DOI: https://doi.org/10.1007/BF00183174