Abstract
This report documents the radiation dosimetry of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane [123I]β-CIT in humans. The mean absorbed doses for various organs and the effective dose equivalent were estimated from whole-body scans, blood samples and single-photon emission tomography scans acquired up to 22 h after the injection of a known amount of tracer. The basal ganglia, the liver and the lower large intestinal wall received the highest mean absorbed doses of 0.270 mGy/MBq, 0.038 mGy/MBq and 0.034 mGy/MBq, respectively. The effective dose equivalent for adults was estimated using 11 organs and the ICRP-87 radiation dose model and was 0.031 mSv/MBq. The radiation dose to the basal ganglia limits the maximum injected activity of [123I]β-CIT to 185 MBq for a single study.
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References
Innis R, Baldwin R, Sybirska E, et al. Single photon emission computed tomography imaging of monoamine reuptake sites in primate brain with [123I]CIT. Eur J Pharmacol 1991;200: 369–370.
Neumeyer JL, Wang S, Milius RA, et al. [123I]2β-Carbomethoxy-3β-(4-iodophenyl)tropane (β-CIT): high affinity SPECT radiotracer of monoamine reuptake sites in brain. J Med Chem 1991;34: 3144–3146.
Kuikka JT, Bergstrom KA, Vanninen E, Laulumaa V, Hartikainen P, Lansimies E. Initial experience with SPET examinations using [123I]-2β-carbomethoxy-3-β-(4-iodophenyl)tropane ([123I]β-CIT) in human brain. Eur J Nucl Med 1993;20: 783–786.
Innis RB, Seibyl JB, Wallace E et al. SPECT imaging demonstrates loss of striatal dopamine transporters in Parkinson's disease [abstract]. J Nucl Med 1993;31: 31P.
Kuikka JT, Tenhunen-Eskelinen M, Jurvelin J, Kiiliäinen H. Physical performance of the Siemens MultiSPECT 3 gamma camera. Nucl Med Commun 1993;14: 490–497.
Ellet WH, Humes RM. Absorbed fractions for small volumes containing photon-emitting radioactivity. MIRD Suppl 5, Pamphlets 7–8. New York: The Society of Nuclear Medicine, 1971.
Weber DA, Eckerman KE, Dillman LT, Ryman JC. MIRD: radionuclide data and decay schemas. New York: The Society of Nuclear Medicine, 1989.
ICRP. Radiation dose to patients from radiopharmaceuticals. ICRP publication 53. Oxford: Pergamon Press, 1987.
123I-IBZM package insert. Cygne b.v. Eindhoven, The Netherlands, 1993.
Verhoeff NPGL, Busemann-Sokole E, Hengst D, Stubbs JB, van Royen EA. Dosimetry of iodine-123 iomazenil in humans. Eur J Nucl Med 1993;20: 580–584.
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Kuikka, J.T., Bergström, K.A., Ahonen, A. et al. The dosimetry of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane. Eur J Nucl Med 21, 53–56 (1994). https://doi.org/10.1007/BF00182306
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DOI: https://doi.org/10.1007/BF00182306