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Exfoliation syndrome as a risk factor for optic disc changes in nonglaucomatous eyes

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Abstract

Exfoliation syndrome as a possible risk factor for morphologic changes of the optic nerve was examined in 66 patients with unilateral exfoliation and no glaucoma. K-readings (7.74 ± 0.3 mm and 7.75 ±0.3 mm), axial lengths (23.1 ± 1.1 mm and 23.1 ±1.1 mm), and refraction (+0.9 ± 2.3 mm and +1.1 ±2.3 mm) did not differ in exfoliative and contralateral nonexfoliative eyes. The mean intraocular pressure (IOP) difference, 17.2 ± 3.3 mmHg and 15.6 ±3.2 mmHg, respectively, was statistically highly significant (P < 0.001). The mean visual acuity difference, 0.8 ±0.3 and 0.9 ± 0.2, respectively, was significant (P < 0.05). The difference in visual acuity between the pairs of eyes was explained by the more frequent subcapsular cataract in exfoliative eyes. Lens opacity values (opacity lens meter), 27.9 ± 8.3 and 28.0 ± 8.4 opacity units, respectively, were similar. Disc area, neuroretinal rim area, rim/disc ratio, cup area, and cup volume values analyzed with the Imagenet (Topcon) nerve head analyzer did not differ significantly between the eyes. It was concluded that exfoliation as such does not induce optic nerve head changes but indicates a risk factor for elevated IOP and lens opacification.

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References

  1. Aasved H (1971) Intraocular pressure in eyes with and without fibrillopathia epitheliocapsularis (so-called senile exfoliation or pseudoexfoliation). Acta Ophthalmol 49:601–610

    Google Scholar 

  2. Airaksinen PJ, Drance SM, Schulzer M (1985) Neuroretinal rim area in early glaucoma. Am J Ophthalmol 99:1–4

    Google Scholar 

  3. Armaly MF (1967) Genetic determination of cup/disc ratio of the optic nerve. Arch Ophthalmol 78:35–43

    Google Scholar 

  4. Bengtsson B (1980) The alteration and asymmetry of cup and disc diameters. Acta Ophthalmol (Copenh) 58:726–732

    Google Scholar 

  5. Britton RJ, Drance SM, Schulzer M, Douglas GR, Mawson DK (1987) The area of neuroretinal rim of the optic nerve in normal eyes. Am J Ophthalmol 103:497–504

    Google Scholar 

  6. Cambiaggi A, Marras A (1988) The relationship between the fluoroangiographic aspect of the optic disc and the visual field in patients with the exfoliation syndrome with and without intraocular hypertension. Part I: bilateral cases. Acta Ophthalmol (Copenh) 66 [Suppl 184]:62–65

    Google Scholar 

  7. Cambiaggi A, Marras A, Ermini D (1988) The relationship between the fluoroangiographic aspect of the optic disc and the visual field in patients with the exfoliation syndrome with and without intraocular hypertension. Part II: monolateral cases. Acta Ophthalmol (Copenh) 66 [Suppl 184]:66–70

    Google Scholar 

  8. Caprioli J, Miller JM (1988) Videographic measurements of optic nerve topography in glaucoma. Invest Ophthalmol Vis Sci 29:1294–1298

    Google Scholar 

  9. De Natale R, Flammer J, Zulauf M, Bebie T (1988) Influence of age on the transparency of the lens in normals: a population study with help of the lens opacity meter 701. Ophthalmologica 197:14–18

    Google Scholar 

  10. Douglas GR, Drance SM, Mikelberg FS, Wijsman K, Schulzer M (1987) Optic nerve head analysis using the Rodenstock analyzer. In: Kriegelstein GK (ed) Glaucoma update. Springer, Berlin Heidelberg New York, pp 106–111

    Google Scholar 

  11. Eagle RC, Font RL, Fine BS (1979) The basement membrane exfoliation syndrome. Arch Ophthalmol 97:510–515

    Google Scholar 

  12. Flammer J, Bebie H (1987) Lens opacity meter: a new instrument to quantify lens opacity. Ophthalmologica 195:69–72

    Google Scholar 

  13. Flammer J, Jenni F, Bebie H, Keller B (1987) The Octopus glaucoma G1 program. Glaucoma 9:67–72

    Google Scholar 

  14. Heijl A (1989) Computerized perimetry in glaucoma management. Acta Ophthalmol (Copenh) 67:1–12

    Google Scholar 

  15. Hiller R, Sperduto RD, Krueger DE (1982) Pseudoexfoliation, intraocular pressure and senile lens changes in a population-based survey. Arch Ophthalmol 100:1080–1082

    Google Scholar 

  16. Interzeag Medical Technology (1988) Opacity lensmeter 701. User's Notes

  17. Iwaki M, Komurasaki Y, Miura M, Kishimoto N, Kondo T (1990) Comparison of the optic nerve head analyzer (Imagenet) in optic disc measurement with a non-stereo image analyzer. Invest Ophthalmol Vis Sci 31 [Suppl]:458

    Google Scholar 

  18. Jonas JB, Gusek GC, Naumann GOH (1988a) Optic disc, cup and neuroretinal rim size configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci 29:1151–1158

    Google Scholar 

  19. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GOH (1988b) Size of the optic nerve scleral canal and comparison with intravital determination of optic disc dimensions. Graefe's Arch Clin Exp Ophthalmol 226:213–215

    Google Scholar 

  20. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GOH (1988c) Variability of the real dimensions of normal human optic discs. Graefe's Clin Exp Ophthalmol 226:332–336

    Google Scholar 

  21. Jonas JB, Gusek GC, Guggenmoos-Holzmann I, Naumann GOH (1988d) Correlations of the neuroretinal rim area with ocular and general parameters in normal eyes. Ophthalmic Res 20:298–303

    Google Scholar 

  22. Jonas JB, Fernandez MC, Naumann GOH (1990) Papillenmorphometrie in Glaukomaugen mit und ohne Pseudoexfoliations-syndrom. Fortschr Ophthalmol 87:150–152

    Google Scholar 

  23. Klemetti A (1988) Intraocular pressure in exfoliation syndrome. Acta Ophthalmol (Copenh) 66 [Suppl 184]:54–58

    Google Scholar 

  24. Kozart DM, Yanoff M (1982) Intraocular pressure status in 100 consecutive patients with exfoliation syndrome. Ophthalmology 89:214–218

    Google Scholar 

  25. Lindberg JG (1989) Clinical investigations on depigmentation of the pupillary border and translucency of the iris. Acta Ophthalmol (Copenh) 67 [Suppl 190]:1–96

    Google Scholar 

  26. Linnér E, Schwartz B, Aranjou D (1989) Optic disc pallor and visual field defect in exfoliative and non-exfoliative, untreated ocular hypertension. Int Ophthalmol 13:21–24

    Google Scholar 

  27. Littman H (1982) Zur Bestimmung der wahren Größe eines Objekts auf dem Hintergrund des lebenden Auges. Klin Monatsbl Augenheilkd 180:286–289

    Google Scholar 

  28. Raitta C, Vesti E (1991) The effect of sodium hyaluronate on the outcome of trabeculectomy. Ophthalmic Surg 22:145–149

    Google Scholar 

  29. Schlötzer-Schrehardt U, Michle M, Naumann GOH (1991) Electron-microscopic identification of pseudoexfoliation material in extrabulbar tissue. Arch Ophthalmol 109:565–570

    Google Scholar 

  30. Tarkkanen A (1962) Pseudoexfoliation of the lens capsule. A clinical study of 418 patients with special reference to glaucoma, cataract and changes of the vitreous. Acta Ophthalmol (Copenh) [Suppl] 71:1–98

    Google Scholar 

  31. Taylor HR (1979) Pseudoexfoliation, an environmental disease? Trans Ophthalmol Soc UK 99:302–307

    Google Scholar 

  32. Vannas A (1969) The angiography of the vessels of the iris in pseudoexfoliation of the lens, capsular glaucoma and some other forms of glaucoma. Acta Ophthalmol (Copenh) [Suppl] 105:9–75

    Google Scholar 

  33. Vannas A (1972) Vascular changes in pseudoexfoliation of lens capsule and capsular glaucoma. A fluorescein angiographic and electron microscopic study. Albrecht von Graefes Arch Klin Exp Ophthalmol 184:248–253

    Google Scholar 

  34. Varma R, Steinmann WC, Spaeth GI, Wilson RP (1988) Variability in digital analysis of optic disc topography. Graefe's Arch Clin Exp Ophthalmol 226:435–442

    Google Scholar 

  35. Varma R, Douglas GR, Steinmann WC, Wijsman K, Mawson D, Spaeth GL (1989) A comparative evaluation of three methods of analyzing optic disc topography. Ophthalmic Surg 20:813–819

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, University of Helsinki, Central Hospital, Haartmaninkatu 4C, SF-00290, Helsinki, Finnland

    Päivi Puska & Christina Raitta

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  1. Päivi Puska
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  2. Christina Raitta
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Correspondence to: P. Puska

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Puska, P., Raitta, C. Exfoliation syndrome as a risk factor for optic disc changes in nonglaucomatous eyes. Graefe's Arch Clin Exp Ophthalmol 230, 501–504 (1992). https://doi.org/10.1007/BF00181768

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  • DOI: https://doi.org/10.1007/BF00181768

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