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l-Dopa reverses the effects of MPP+ toxicity

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Abstract

The behavioral and neurochemical consequences of the intrastriatal administration of 1-methyl-4-phenylpyridinium ion (MPP+), the toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were evaluated using the shuttlebox avoidance paradigm. MPP+ caused a significant depletion of striatal dopamine and significant disruption of shuttlebox performance. L-Dopa administration reversed both the dopamine depletion and the behavioral deficits. These observations are discussed in reference to the rodent-MPTP model of Parkinson's disease.

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Authors and Affiliations

  1. Department of Psychology, Rutgers, The State University, 08903, New Brunswick, NJ, USA

    George C. Wagner, Michael F. Jarvis & Jared G. Rubin

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  1. George C. Wagner
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  2. Michael F. Jarvis
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  3. Jared G. Rubin
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Offprint requests to: G.C. Wagner

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Wagner, G.C., Jarvis, M.F. & Rubin, J.G. l-Dopa reverses the effects of MPP+ toxicity. Psychopharmacology 88, 401–402 (1986). https://doi.org/10.1007/BF00180846

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  • DOI: https://doi.org/10.1007/BF00180846

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