Abstract
Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.
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Abbreviations
- NDI:
-
nephrogenic diabetes insipidus
- DNDI:
-
drug-induced nephrogenic diabetes insipidius
- ICU:
-
intensive care unit
- PGE2 :
-
Prostaglandin E2
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Correspondence to: K.-H. Meyer zum Buschenfelde
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Höhler, T., Teuber, G., Wanitschke, R. et al. Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus. Clin Investig 72, 769–771 (1994). https://doi.org/10.1007/BF00180544
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DOI: https://doi.org/10.1007/BF00180544