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Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice

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Abstract

Clenbuterol, isoproterenol and salbutamol increased the latency in the licking response of mice on the hot plate at 56.5° C. This effect was dose-related and obtained after IP administration. Clenbuterol was active at lower doses than isoproterenol and salbutamol, a result which is consistent with its better penetration in the central nervous system. Moreover, the effect of clenbuterol was stereospecific, the (−)-isomer being the active form. Our results suggest the implication of central beta-adrenoceptors in the modulation of the response to a painful stimulation.

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Authors and Affiliations

  1. Départment de Pharmacologie, Faculté de Médicine Pitié-Salpêtrière, 91, Boulevard de l'Hôpital, F-75634, Paris Cédex 13, France

    Denis Brochet, Patrick Martin & Pierre Simon

  2. Departamento de Farmacologia, Facultad de Medicina, Plaza de Falla, 11003, Cádiz, España

    Juan-Antonio Micó

Authors
  1. Denis Brochet
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  2. Juan-Antonio Micó
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  3. Patrick Martin
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  4. Pierre Simon
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Brochet, D., Micó, JA., Martin, P. et al. Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice. Psychopharmacology 88, 527–528 (1986). https://doi.org/10.1007/BF00178520

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  • DOI: https://doi.org/10.1007/BF00178520

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