Abstract
The diurnal variation of plasma beta endorphin was studied in ten schizophrenics, and in age/sex matched control subjects. In the controls beta endorphin was high in the morning (21.0±3.5 pmol/l) and decreased towards evening. In the schizophrenic group the beta endorphin fluctuated randomly, ranging within 9–40 pmol/l throughout the day. Plasma cortisol showed a normal diurnal pattern in both groups. The mean plasma cortisol levels in the schizophrenics were significantly higher than in the controls throughout the day. The pattern of plasma human growth hormone (hGH) level was similar in both groups at the time tested. It is hypothesized that the instability of beta endorphin secretion may contribute to the pathogenesis of schizophrenia.
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Berger PA, Watson SY, Akil H, Elliott GK, Rubin RT, Pfefferbaum A, Davis KL, Barchas JD, Li CH (1980) Beta endorphin and schizophrenia. Arch Gen Psychiatry 37:635–640
Brambilla F, Gennazzani A, Faccinetti F (1984) Endogenous opioid peptides in schizophrenia and affective disorders. In: Shah NS, Donald AG (eds) Psychoneuroendocrine dysfunction. Plenum Medical Book Co., New York, pp 309–329
Brown GM, Garfinkel PE, Grof E, Grof P, Cleghorn JM, Brown P (1983) A critical appraisal of neuroendocrine approaches to psychiatric disorders. In: Muller EE, MacLeod RM (eds) Neuroendocrine perspectives, vol. 2. Elsevier Sci Publ BY, pp 329–364
Dent RRM, Guilleminault C, Albert LH, Posner BI, Cox BM, Goldstein A (1981) Diurnal rhythm of plasma immunoreactive beta endorphin and its relationship to sleep stages and plasma rhythms of cortisol and prolactin. J Clin Endocrinol Metab 52:942–947
Domschke W, Dickshas A, Mitznegg P (1979) CSF beta endorphin in schizophrenia. Lancet I:1024
Emrich H, Hollt V, Kissling W, Fischler M, Laspe H, Heinemann H, Von Zerssen D, Herz A (1979) Beta endorphin like immunoreactivity in cerebrospinal fluid and plasma of patients with schizophrenia and other neuropsychiatric disorders. Pharmakopsychiatrie 12:269–276
Farsang C, Vajda L, Kapocsi J, Malisaki Z, Alfoldi S, Varga K, Kunos G (1983) Diurnal rhythm of beta endorphin in normotensive and hypertensive patients: the effect of clonidine. J Clin Endocrinol Metab 56:865–867
Ferrier N, Johnstone C, Crow TJ, Rincon Rodriguez I (1983) Anterior pituitary hormone secretion in chronic schizophrenia. Arch Gen Psychiatry 40:755–761
Gil-Ad I, Dickerman Z, Weitzman R, Weitzman A, Tyano S, Laron Z (1981) Abnormal GH response to LRH and TRH in adolescent schizophrenic patients. Am J Psychiatry 138:357–361
Gruen PH (1978) Endocrine changes in psychiatric diseases. Med Clin North Am 62:285–296
Guillemin R, Varga T, Rossier J, Minick S, Ling N, Rivier C, Vale W, Bloom F (1977) Beta endorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197:1367–1369
Jacquet YF (1980) Beta endorphin, blood brain barrier and schizophrenia. Lancet I:831
Kline NS, Li CH, Lehmann HE, Laytha A, Laski E, Cooper T (1977) Beta endorphin induced changes in schizophrenic and depressed patients. Arch Gen Psychiatry 34:1111–1113
Rapoport SI, Klee WA, Pettigrew KD, Ohno K (1980) Entry of opioid peptides into the central nervous system. Science 207:84–86
Spiegel MR (1981) Theory and problems of statistics. McGraw Hill Book Co., New York
Spitzer RL, Endicott J, Robins E (1975) Research Diagnostic Criteria (RDC) for a selected group of functional disorders, 2nd ed. New York State Psychiatric Institute, Biometrics Research, New York
Terenius L, Wahlstrom A, Lindstrom L, Widerlon E (1976) Increased CSF levels of endorphins in chronic psychosis. Neurosci Lett 3:157–162
Van Ree JM, De Wied D (1981) Endorphins in schizophrenia. Neuropharmacology 20:1271–1277
Verhoeven WMA, Van Praag HM, De Jong JTVM (1981) Use of naloxone in schizophrenic psychoses and manic syndromes. Neuropsychobiology 7:159–168
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Gil-Ad, I., Dickerman, Z., Amdursky, S. et al. Diurnal rhythm of plasma beta endorphin, cortisol and growth hormone in schizophrenics as compared to control subjects. Psychopharmacology 88, 496–499 (1986). https://doi.org/10.1007/BF00178514
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DOI: https://doi.org/10.1007/BF00178514