Summary
Twelve patients aged 34 to 65 with malignant gliomas were treated with VP-16, Procarbazine, Vincristine and concurrent radiation therapy. There were 9 patients with glioblastoma multiforme and 3 with anaplastic astrocytoma. All patients had a subtotal resection or biopsy as the initial procedure.
Six patients (1 anaplastic astrocytoma) have developed progressive disease. Mean time to tumor progression was 46 weeks. This combined modality treatment program was associated with reversible hematologic toxicity which was severe in 2 patients. These data compare favorably to data obtained from similiar patients treated with radiation therapy and BCNU.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Edwards MS, Levin VA, and Wilson CB: Brain tumor chemotherapy: An evaluation of agents in current use for phase II and III trials. Cancer Treat Rep 64: 1179–1205, 1980
Tirelli V, D'Incalci M, Canetta R, Tumolo S, Franchin G, Veronsi A, Galligioni E, Trovo MG, Rossi C, Grigoletto: Etoposide (VP-16–2130) in malignant brain tumors: a phase II study. J Clin Oncol 2: 432–437, 1984
Jackson DV, Long TR, Trahey TF, Morgan TM: Synergistic anti-tumor activity of vincristine and VP-16–213. Cancer Chemotherapy Pharmacol 13: 176–180, 1984
Jackson DV, Wells HB, White DR, Muss HB, II Richards F, Cooper MR, Stuart JJ, Pope EK, Spurr CL: Lack of potentiation of vincristine-induced neurotoxicity by VP-16–213. Am J Clin Oncol 6: 327–330, 1983
Levin VA, Wara WM, Davis RL, Vestnys P, Resser KJ, Yatsko K, Nutik S, Gutin PH, Wilson CB: Phase III comparison of BCNU and the combination of procarbazine, CCNU and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas. J Neurosurg 63: 218–233, 1985
Rodriguez LA, Levin VA. Does chemotherapy benefit the patient with a central nervous system glioma? Oncology 1: 29–36, 1987
Johnson DB, Thompson JM, Corwin JA, Mosely KR, Smith MT, de los Reyes RA, Daly MB, Petty AM, Lamaster D, Pierson WP, Jr Ruxer RL, Leff RS, Messerschmidt: Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation. J Clin Oncol 5: 783–789, 1987
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hellman, R.M., Calogero, J.A. & Kaplan, B.M. VP-16, vincristine and procarbazine with radiation therapy for treatment of malignant brain tumors. J Neuro-Oncol 8, 163–166 (1990). https://doi.org/10.1007/BF00177840
Issue Date:
DOI: https://doi.org/10.1007/BF00177840