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Integrins in human anterior chamber angle

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Abstract

•Background: Integrins, which are composed of an α and β subunit, are capable of binding to a number of extracellular matrix proteins and, hence, affect cell adhesion and proliferation.

•Methods: The distribution of the integrin β (β1, β3-β5) and α (α1–6 and αv) subunits in human anterior chamber angle was studied in eyes from subjects aged 9 months to 81 years using the indirect immunofluorescence technique.

•Results: Immunoreaction for the β1 subunit was found throughout the trabecular meshwork (TM), in the cribriform layer, and in the endothelial lining of Schlemm's canal (SC). Labelling for the α3 subunit was found in the TM and the cribriform layer only. In infant eyes the α5 subunit was present in all three areas with the highest concentration in the cribriform layer, whereas no reaction was observed in adult eyes. The α6 subunit was localized to the endothelium of SC only. Immunoreaction for the αv subunit was present in the TM and the cribriform layer of infants and young adults.

•Conclusion: The present results suggest the presence of several integrin heterodimers, acting as potential receptors for laminin, collagen, fibronectin, and vitronectin, in the anterior chamber angle.

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Authors and Affiliations

  1. Department of Anatomy, Institute of Biomedicine, University of Helsinki, (Siltavuorenpenger 20 A), P.O. Box 9, FIN-00014, Helsinki, Finland

    K. Tervo, T. Päällysaho & I. Virtanen

  2. Department of Ophthalmology, University of Helsinki, Haartmanninkatu 4C, FIN-00290, Helsinki, Finland

    T. Tervo

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  1. K. Tervo
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  2. T. Päällysaho
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  3. I. Virtanen
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Tervo, K., Päällysaho, T., Virtanen, I. et al. Integrins in human anterior chamber angle. Graefe's Arch Clin Exp Ophthalmol 233, 291–295 (1995). https://doi.org/10.1007/BF00177651

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  • DOI: https://doi.org/10.1007/BF00177651

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