References
Arden, B. and Klein, J. Biochemical comparison of major histocompatibility complex molecules from different subspecies of Mus musculus: evidence for trans-specific evolution of alleles. Proc Natl Acad Sci USA 79: 2342–2346, 1982
Bailey, D. W. and Kohn, H. I. Inherited histocompatibility changes in progeny or irradiated and unirradiated inbred mice. Genet Res 6: 330–340, 1965
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., and Wiley, D. C. Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329: 506–512, 1987 a
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., and Wiley, D. C. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329: 512–518, 1987 b
Brown, J. H., Jardetzky, T., Saper, M. A., Samraoui, B., Bjorkman, P. J., and Wiley, D. C. A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 332: 845–850, 1988
Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L., and Wiley, D. C. Three dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364: 33–39, 1993
Bulmer, M., Wolfe, K. H., and Sharp, P. M. Synonymous nucleotide substitution rates in mammalian genes: implications for the molecular clock and the relationship of mammalian orders. Proc Natl Acad Sci USA 88: 5974–5978, 1991
Clark, A. G. Evolutionary inferences from molecular characterization of self-incompatibility alleles. In N. Takahata and A. G. Clark (eds.): Mechanisms of Molecular Evolution, pp. 79–108, Sinauer, Sunderland, 1993
Clarke, A. G. The effects of maternal pre-immunization on pregnancy in the mouse. J Reprod Fertil 24: 369–375, 1971
Clarke, B. and Kirby, D. R. S. Maintenance of histocompatibility complex polymorphisms. Nature 211: 999–1000, 1966
Doherty, P. C. and Zinkernagel, R. Enhanced immunologic surveillance in mice heterozygous at the H-2 gene complex. Nature 256: 50–52, 1975
Duncan, W. R., Wakeland, E. K., and Klein, J. Heterozygosity of H-2 loci in wild mice. Nature 281: 603–605, 1979
Egid, K. and Brown, J. L. The major histocompatibility complex and female mating preferences in mice. Anim Behav 38: 548–549, 1989
Engelhard, V. H. Structure of peptides associated with class I MHC molecules. Curr Opin Immunol 6: 13–23, 1994
Garber, T. L., Hughes, A. L., Letvin, N. L., Templeton, J. W., and Watkins, D. I. Sequence and evolution of cattle MHC class I cDNAs: concerted evolution has not taken place in cattle. Immunogenetics 38: 11–20, 1993
Garrett, T. P. J., Saper, M. A., Bjorkman, P. J., Strominger, J. L., and Wiley, D. C. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 342: 692–696, 1989
Gilbert, A. N., Yamazaki, K., Beauchamp, G. K., and Thomas, L. Olfactory discrimination of mouse strains (Mus musculus) and major histocompatibility types by humans (Homo sapiens). J Comp Psychol 100: 262–265, 1986
Hedrick, P. W. and Thomson, G. Evidence for balancing selection at HLA. Genetics 104: 449–456, 1983
Hughes, A. L. Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenetic regions. Genetics 127: 345–353, 1991
Hughes, A. L. Positive selection and interallelic recombination at the merozoite surface antigen-1 (MSA-1) locus of Plasmodium falciparum. Mol Biol Evol 9: 381–393, 1992
Hughes, A. L. Origin and evolution of HLA class I pseudogenes. Mol Biol Evol 12: 247–258, 1995
Hughes, A. L. and Nei, M. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335: 167–170, 1988
Hughes, A. L. and Nei, M. Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proc Natl Acad Sci USA 86: 958–962, 1989
Hughes, A. L., Ota, T., and Nei, M. Positive Darwinian selection promotes charge profile diversity in the antigen binding cleft of class I MHC molecules. Mol Biol Evol 7: 515–524, 1990
Hughes, A. L., Hughes, M. K., Howell, C. Y., and Nei, M. Natural selection at the class II major histocompatibility complex loci of mammals. Phil Trans R Soc B 345: 359–367, 1994
James, D. A. Effects of antigenic dissimilarity between mother and foetus on placental size in mice. Nature 205: 613–614, 1965
James, D. A. Some effects of immunological factors on gestation in mice. J Reprod Fertil 14: 265–275, 1967
Jiang, W., Gorbea, C. M., Flannery, A. V., Beynon, R. J., Grant, G. A., and Bond, J. S. The α subunit of meprin A: molecular cloning and sequencing, differential expression in inbred mouse strains, and evidence for divergent evolution of the α and β subunits. J Biol Chem 267: 9185–9193, 1992
Jiang, W., Sadler, P. M., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., and Bond, J. S. Tissue-specific expression and chromosomal localization of the α subunit of mouse meprin A. J Biol Chem 268: 10380–10385, 1993
Kimura, M. Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature 267: 275–276, 1977
Kimura, M. The Neutral Theory of Molecular Evolution, Cambridge University Press, Cambridge, 1983
Klein, J. Natural History of the Major Histocompatibility Complex, Wiley, New York, 1986
Lawlor, D. A., Ward, F. E., Ennis, P. D., Jackson, A. P., and Parham, P. HLA-A, B polymorphisms predate the divergence of humans and chimpanzees. Nature 335: 268–271, 1988
Li, W.-H., Wu, C.-I., and Luo, C.-C. A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes. Mol Biol Evol 2: 150–174, 1985
Li, W.-H., Gouy, M., Sharp, P. M., O'hUigin, C., and Yang, Y. W. Molecular phylogeny of Rodentia, Primates, Artiodactyla, and Carnivora and molecular clocks. Proc Natl Acad Sci USA 87: 6703–6707, 1990
Lidicker, W. Z., Jr. and Patton, J. L. Patterns of dispersal and genetic structure in populations of small rodents. In B. D. Chepko-Sade and Z. T. Halpin (eds.): Mammalian Dispersal Patterns, pp. 144–161, University of Chicago Press, Chicago, 1987
López de Castro, J. A., Strominger, J. L., Strong, D. M., and Orr, H. T. Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism. Proc Natl Acad Sci USA 79: 3813–3817, 1982
McAdam, S. N., Boyson, J. E., Liu, X., Garber, T. L., Hughes, A. L., Bontrop, R. E., and Watkins, D. I. A uniquely high level of recombination at the HLA-B locus. Proc Natl Acad Sci USA 91: 5893–5897, 1994
McConnell, T. J., Talbot, W. S., McIndoe, R. A., and Wakeland, E. K. The origin of MHC class II gene polymorphism within the genus Mus. Nature 332: 651–654, 1988
Mayer, W. E., Jonker, D., Klein, D., Ivanyi, P., van Seventer, G., and Klein, J. Nucleotide sequence of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution. EMBO J 7: 2765–2774, 1988
Monos, D. S., Tekolf, W. A., Shaw, S., and Cooper, H. L. Comparison of structural and functional variation in class I HLA molecules: the role of charged amino acid substitution. J Immunol 132: 1379–1385, 1984
Nathenson, S. G., Geleibter, J., Pfaffenbach, G. M., and Zeff, R. A. Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications. Annu Rev Immunol 4: 471–502, 1986
Nei, M. Molecular Evolutionary Genetics, Columbia University Press, New York, 1987
Nei, M. and Gojobori, T. Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3: 418–426, 1986
Parham, P., Lawlor, D. A., Lomen, C. E., and Ennis, P. D. Diversity and diversification of HLA-A,B,C alleles. J Immunol 142: 3937–3950, 1989
Potts, W. K., Manning, C. J., and Wakeland, E. K. Mating patterns in seminatural populations of mice influenced by MHC genotype. Nature 352: 619–621, 1991
Rammensee, H. G., Friede, T., and Stevanović, S. MHC ligands and peptide motifs: first listing. Immunogenetics 4: 178–228, 1995
Reckelhoff, J. F., Bond, J. S., Beynon, R. J., Savarirayan, S., and David, C. S. Proximity of the Mep-1 gene to H-2D on chromosome 17 in mice. Immunogenetics 22: 617–623, 1985
Saper, M. A., Bjorkman, P. J., and Wiley, D. C. Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution. J Mol Biol 219: 277–319, 1991
Satta, Y. Balancing selection at the HLA loci. In N. Takahata and A. G. Clark (eds.): Mechanisms of Molecular Evolution, pp. 129–149, Sinauer, Sunderland, MA, 1993
Satta, Y., O'hUigin, C., Takahata, N., and Klein, J. The synonymous substitution rate of the major histocompatibility complex loci in primates. Proc Natl Acad Sci USA 90: 7480–7484, 1993
Takahata, N. and Nei, M. Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci. Genetics 124: 967–978, 1990
Thomas, L. Biological signals for self-identification. In L. Brent and J. Holborrow (eds.): Progress in Immunology II, pp. 239–247, North-Holland, Amsterdam, 1974
Tulp, A., Verwoerd, D., Dobberstein, B., Ploegh, H., and Pleters, J. Isolation and characterization of the intracellular MHC class II compartment. Nature 369: 120–126, 1994
Watkins, D. I., Garber, T. L., Chen, Z. W., Toukatly, G., Hughes, A. L., and Letvin, N. L. Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus). Immunogenetics 33: 79–89, 1991
Watkins, D. I., McAdam, S. N., Liu, X., Stang, C. R., Milford, E. L., Levine, C. G., Garber, T. L., Dogon, A. L., Lord, C. I., Ghim, S. H., Troup, G. M., Hughes, A. L., and Letvin, N. L. New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. Nature 357: 329–333, 1992
Wegmann, T. G. Foetal protection against abortion: is it immunosuppression or immunostimulation? Ann Immunol 135B: 307–312, 1984
Williams, A. F. and Barclay, A. N. The immunoglobulin superfamily: domains for cell surface recognition. Annu Rev Immunol 6: 381–405, 1988
Wolfe, K. H., Sharp, P. M., and Li, W.-H. Mutation rates vary among regions of the mammalian genome. Nature 337: 283–285, 1989
Yamazaki, K., Boyse, E. A., Miké, V., Thaler, H. T., Mathieson, B. J., Abbott, J., Boyse, J., Zayas, Z. A., and Thomas, L. Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med 144: 1324–1335, 1976
Yamazaki, K., Yamaguchi, M., Baranowski, L., Bard, J., Boyse, E. A., and Thomas, L. Recognition among mice: evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types. J Exp Med 150: 755–760, 1979
Yuhki, N. and O'Brien, S. J. DNA recombination and natural selection pressure sustain genetic sequence diversity of the feline MHC class I genes. J Exp Med 172: 621–630, 1990
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Hughes, A.L., Hughes, M.K. Natural selection on the peptide-binding regions of major histocompatibility complex molecules. Immunogenetics 42, 233–243 (1995). https://doi.org/10.1007/BF00176440
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DOI: https://doi.org/10.1007/BF00176440