Skip to main content
Log in

Estimation of the number of amino acid substitutions per site when the substitution rate varies among sites

  • Letter to the Editor
  • Published:
Journal of Molecular Evolution Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bulmer M (1991) Use of the method of generalized least squares in reconstructing phylogenies from sequence data. Mol Biol Evol 8:868–883

    Google Scholar 

  • Dayhoff MO, Eck RV, Park CM (1972) A model of evolutionary change in proteins. In: Dayhoff MO (ed) Atlas of protein sequence and structure, vol 5. National Biomedical Research Foundation, Washington, DC, pp 89–99

    Google Scholar 

  • Dayhoff MO, Schwartz RM, Orcutt BC (1978) A model of evolutionary change in proteins. In: Dayhoff MO (ed) Atlas of protein sequence and structure, vol 5, suppl 3. National Biomedical Research Foundation, Washington, DC, pp 345–352

    Google Scholar 

  • Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge, England, pp 65–97

    Google Scholar 

  • Nei M, Chakraborty R, Fuerst PA (1976) Infinite allele model with varying mutation rate. Proc Natl Acad Sci USA 73:4164–4168

    Google Scholar 

  • Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New York, pp 39–46

    Google Scholar 

  • Ota T, Nei M (1994) Divergent evolution and evolution by the birth-and-death process in the immunoglobulin VH gene family. Mol Biol Evol (accepted)

  • Rzhetsky A, Nei M (1992) A simple method for estimating and testing minimum evolution trees. Mol Biol Evol 9:945–967

    CAS  Google Scholar 

  • Uzzell T, Corbin KW (1971) Fitting discrete probability distributions to evolutionary events. Science 172:1089–1096

    Google Scholar 

  • Zuckerkandl E, Pauling L (1965) Evolutionary divergence and convergence in proteins. In Bryson V, Vogel HJ (eds) Evolving genes and proteins. Academic Press, New York, pp 97–166

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Correspondence to: M. Nei 0871

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ota, T., Nei, M. Estimation of the number of amino acid substitutions per site when the substitution rate varies among sites. J Mol Evol 38, 642–643 (1994). https://doi.org/10.1007/BF00175885

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00175885

Key words

Navigation