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Striatal dopamine uptake asymmetries and rotational behavior in unlesioned rats: revising the model?

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Abstract

The relationship between circling behavior and the dopaminergic (DA) innervation of the striatum was investigated in rats. Vmax for DA uptake in crude mitochondrial (P2) fractions was used as a measure of the density of striatal DA terminals. Females, as a group, rotated away from (i.e., contralateral to) the side containing the higher V max for DA uptake, while there was a nonsignificant trend in the opposite direction for the males. Further analysis suggested that in both sexes there are two kinds, or populations, of rats: those with their turning biases directed away from (Contra>Ipsi rats), and those with their turning biases directed towards (Ipsi>Contra rats) the side containing the striatum with the higher V max for DA uptake. Evidence supporting this two-population hypothesis includes: (a) For both groups of rats the slope of the best fit linear relationship between the contralateral/ipsilateral V max asymmetry and rotational behavior is equal in magnitude, though opposite in sign; (b) Mean contralateral V max is greater for the Contra>Ipsi rats than for the Ipsi>Contra rats, while the mean ipsilateral V max is virtually identical for the two groups; (c) The two groups of rats can be differentiated behaviorally on the basis of a measure of total lateralized activity, % turning. In addition, the K m for DA uptake for the females (1.81±0.07×10−7 M) was found to be significantly greater than for the males (1.51±0.04×10−7 M; P<0.005).

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Authors and Affiliations

  1. Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, One Gustave L. Levy Place, 10029, New York, New York, USA

    Raymond M. Shapiro

  2. Department of Pharmacology and Toxicology, Albany Medical College of Union University, 47 New Scotland Avenue, 12208, Albany, New York, USA

    Stanley D. Glick & Lindsay B. Hough

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  1. Raymond M. Shapiro
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  2. Stanley D. Glick
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  3. Lindsay B. Hough
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Shapiro, R.M., Glick, S.D. & Hough, L.B. Striatal dopamine uptake asymmetries and rotational behavior in unlesioned rats: revising the model?. Psychopharmacology 89, 25–30 (1986). https://doi.org/10.1007/BF00175184

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  • DOI: https://doi.org/10.1007/BF00175184

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