Abstract
The effect of steady-state moderate hypoglycaemia on human brain homeostasis has been studied with positron emission tomography using [U-11C]-D-glucose as tracer. To rule out any effects of insulin, the plasma insulin concentration was maintained at the same level under normo- and hypoglycaemic conditions. Reduction of blood glucose by 55% increased the glucose clearance through the blood-brain barrier by 50% and reduced brain glucose consumption by 40%. Blood flow was not affected. The results are consistent with facilitated transport of glucose from blood to brain in humans. The maximal transport rate of glucose from blood to brain was found to be 62±19 (mean±SEM) μmol hg−1 min−1, and the half-saturation constant was found to be 4.1 + 2.3 mM.
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References
Blomqvist G (1984) On the construction of functional maps in positron emission tomography. J Cereb Blood Flow Metab 4:629–632
Blomqvist G, Stone-Elander S, Halldin C, Roland PE, Widen L, Lindqvist M, Swahn C-G, Låtröm B, Wiesel FA (1990) Positron emission tomography measurements of cerebral glucose utilization using [1-11C]-d-glucose. J Cereb Blood Flow Metab 9:467–484
Brooks DJ, Gibbs SR, Sharp P, Herold S, Turton DR, Luthra SK, Kohner EM, Bloom SR, Jones T (1986) Regional cerebral glucose transport in insulin dependent diabetic patients studied using [11C]3-O-methyl-d-glucose and positron emission tomography. J Cereb Blood Flow Metab 6:240–244
Ehrin E, Stone-Elander S, Nilsson JLG, Bergström M, Blomqvist G, Brismar T, Eriksson L, Greitz T, Jansson PE, Litton JE, Malmborg P, af Ugglas M, Widen L (1983) C-11-labelled glucose and its utilization in positron emission tomography. J Nucl Med 24:311–326
Gjeddc A (1983) Modulation of substrate transport to the brain. Acta Neurol Scand 67:3–25
Gottstein U, Held K (1967) Insulinwirkung auf den menschlichen Hirnmetabolismus von Stoffwechselgesunden and Diabetikern. Klin Wochenschr 45:18–23
Gutniak M, Blomqvist G, Widen L, Stone-Elander S, Hamberger B, Grill V (1990) Brain uptake and metabolism of [U-11C]-d-glucose in insulin-dependent diabetic subjects. Am J Physiol 258 (Endocrinol Metab 21):E805-E812
Pardridge WH (1983) Brain metabolism from the blood-brain barrier. Physiol Rev 63:1481–1535
Shapiro ET, Cooper M, Chen C-T, Given BD, Polonsky K (1990) Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans. Diabetes 39:175–180
Suda S, Shinohara M, Miyaoka M, Lucignani G, Kennedy C, Sokoloff L (1990) The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization in the rat. J Cereb Blood Flow Metab 10:499–509
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Blomqvist, G., Gjedde, A., Gutniak, M. et al. Facilitated transport of glucose from blood to brain in man and the effect of moderate hypoglycaemia on cerebral glucose utilization. Eur J Nucl Med 18, 834–837 (1991). https://doi.org/10.1007/BF00175064
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DOI: https://doi.org/10.1007/BF00175064