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Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family

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Abstract

We have characterized two cDNA clones from the nematode Caenorhabditis elegans that display similarity to the alcohol dehydrogenase (ADH) gene family. The nucleotide sequences of these cDNAs predict that they encode Zn-containing long-chain ADH enzymes. Phylogenetic analysis suggests that one is most similar to dimeric class III ADHs found in diverse taxa; the other is most similar to the tetrameric forms of ADH previously described only in fungi.

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Authors and Affiliations

  1. Program in Genetics, University of New Hampshire, 03824, Durham, NH, USA

    Jeremy D. Glasner, Thomas D. Kocher & John J. Collins

  2. Department of Zoology, University of New Hampshire, 03824, Durham, NH, USA

    Thomas D. Kocher

  3. Department of Biochemistry and Molecular Biology, University of New Hampshire, 03824, Durham, NH, USA

    John J. Collins

Authors
  1. Jeremy D. Glasner
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  2. Thomas D. Kocher
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  3. John J. Collins
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Correspondence to: J.J. Collins

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Glasner, J.D., Kocher, T.D. & Collins, J.J. Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family. J Mol Evol 41, 46–53 (1995). https://doi.org/10.1007/BF00174040

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  • DOI: https://doi.org/10.1007/BF00174040

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