Abstract
Lysine secretion in wild-type Corynebacterium glutamicum was investigated by means of dipeptide feeding during short-term fermentation. It could be shown that important properties of lysine excretion, e. g. dependence on membrane potential and the internal Michaelis constant (K m), are not different for the producing strain DG 52-5 and the wild type. The main difference seems to refer to regulatory properties of the lysine excretion carrier activity. The transport of lysine in the wild type is regulated by the presence and kind of carbon sources. These differences in transport activity are not due to changes in the driving force. A possible distinction between phosphotransferase system (PTS) and non-PTS carbon sources with respect to the observed regulatory phenomena is discussed.
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Erdmann, A., Weil, B. & Krämer, R. Lysine secretion by Corynebacterium glutamicum wild type: regulation of secretion carrier activity. Appl Microbiol Biotechnol 42, 604–610 (1994). https://doi.org/10.1007/BF00173927
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DOI: https://doi.org/10.1007/BF00173927