Abstract
Amphetamine and other psychostimulant drugs induce perseverative motor behavior in rodents, such as compulsive sniffing, licking and biting. Although it is known that this behavior, termed stereotypy, is a consequence of dopaminergic stimulation of the striatum, the precise localization of the site of activation is unclear. It is reported here that microinjection of amphetamine (20μg/0.5μl) into a circumscribed subregion of the striatum specifically produces intense oral stereotypy. It is proposed that this region, which corresponds to a small area within the ventrolateral striatum, contains motor circuitry critical to oral behavior, including feeding. The behavior elicited by amphetamine-induced stimulation of this area may represent a simple animal model in which to study certain orofacial dyskinesias.
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Kelley, A.E., Lang, C.G. & Gauthier, A.M. Induction of oral stereotypy following amphetamine microinjection into a discrete subregion of the striatum. Psychopharmacology 95, 556–559 (1988). https://doi.org/10.1007/BF00172976
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DOI: https://doi.org/10.1007/BF00172976