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Adrenergic and adrenolytic effects on intraocular pressure

  • Clinical Investigations
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Abstract

We compared the pressure-lowering effects of timolol, pindolol, epinephrine and the mixture of timolol and epinephrine with that of placebo over a 12-h period. All agents reduced the pressure significantly but with varying time courses. The mixture of timolol and epinephrine reduced the pressure significantly more than did timolol or epinephrine alone, especially at 12 h after the last administration of the drops.

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Authors and Affiliations

  1. Department of Ophthalmology, University of British Columbia, 2550 Willow Street, V5Z 3N9, Vancouver, B.C., Canada

    Stephen M. Drance, Gordon R. Douglas & Kees J. Wijsman

  2. Department of Medicine, University of British Columbia, 2550 Willow Street, V5Z 3N9, Vancouver, B.C., Canada

    Michael Schulzer

Authors
  1. Stephen M. Drance
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  2. Gordon R. Douglas
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  3. Kees J. Wijsman
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  4. Michael Schulzer
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Additional information

Supported in part by Medical Research Council grant MT-1578

Offprint requests to: S.M. Drance

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Drance, S.M., Douglas, G.R., Wijsman, K.J. et al. Adrenergic and adrenolytic effects on intraocular pressure. Graefe's Arch Clin Exp Ophthalmol 229, 50–51 (1991). https://doi.org/10.1007/BF00172260

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  • DOI: https://doi.org/10.1007/BF00172260

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