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Hsp70 genes are linked to the Xenopus major histocompatibility complex

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Abstract

Some of the inducible forms of the heat shock protein 70 (Hsp70) gene family are encoded in the class III region of the major histocompatibility complex (MHC) of mammals. This study was undertaken to determine whether Hsp 70 genes are linked to the MHC of Xenopus, an amphibian last sharing a common ancestor with mammals 300–350 million years ago. Segregation analyses involving seven haplotypes demonstrated the linkage of two or three inducible Hsp70 genes to the frog MHC. Another Hsp70 gene is not closely linked to the MHC. We conclude that the physical association of MHC class I and class II genes with Hsp70 genes is ancient.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Miami School of Medicine, P. O. Box 016960 (R138), 33 101, Miami, FL, USA

    Luisa Salter-Cid & Martin F. Flajnik

  2. Department of Biochemistry, Hokkaido University School of Medicine, Kita 15 Nishi 7, 060, Sapporo, Japan

    Masanori Kasahara

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  1. Luisa Salter-Cid
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  2. Masanori Kasahara
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  3. Martin F. Flajnik
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Correspondence to: M. F. Flajnik.

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Salter-Cid, L., Kasahara, M. & Flajnik, M.F. Hsp70 genes are linked to the Xenopus major histocompatibility complex. Immunogenetics 39, 1–7 (1994). https://doi.org/10.1007/BF00171790

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  • DOI: https://doi.org/10.1007/BF00171790

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