References
Mundy GR. The hypercalcemia of malignancy. Kidney Int 1987;31:142–155.
Mundy GR. Hypercalcemia of malignancy revisited. J Clin Invest 1988;82:1–6.
Coleman RE, Rubens RD. Bone metastases and breast cancer. Cancer Treat Rev 1985;12:251–270.
Gillespie PJ, Alexander JL, Edelstyn GA. Changes in 87mSr concentrations in skeletal metastases in patients responding to cyclical combination chemotherapy for advanced breast cancer. J Nuct Med 1975;16:191–193.
Alexander JL, Gillespie PJ, Edelstyn GA. Serial bone scanning using technetium 99m diphosphonate in patients undergoing cyclical combination chemotherapy for advanced breast cancer. Clin Nucl Med 1976;1:13–17.
Greenberg EJ, Chu FCH, Dwyer AJ, Ziminski EM, Dimich AB, Laughlin JS. Effects of radiation therapy on bone lesions as measured by 47Ca and 85Sr local kinetics. J Nucl Med 1972;13:747–751.
McNeil BJ. Value of bone scanning in neoplastic disease. Semin Nucl Med 1984;14:277–286.
Rossleigh MA, Lovegrove FTA, Reynolds PM, Byrne MJ. Serial bone scans in the assessment of response to therapy in advanced breast carcinoma. Clin Nucl Med 1982;7:397–402.
Rossleigh MA, Lovegrove FTA, Reynolds PM, Byrne MJ, Whitney BP. The assessment of response to therapy of bone metastases in breast cancer. Aust NZ J Med 1984;14:19–22.
Coleman RE, Mashiter G, Whitaker KB, Moss DW Rubens RD, Fogelman I. Bone scan flare predicts successful systemic therapy for bone metastases. J Nucl Med 1988;29:1354–1359.
Coleman RE, Mashiter G, Fogelman I, Whitaker KD, Caleffi M, Moss DW Rubens RD. Osteocalcin: a potential marker of marker of metastatic bone disease and response to treatment. Eur J Cancer Clin Oncol 1988;24:1211–1217.
Coleman RE, Whitaker KB, Moss DW Mashiter G, Fogelman I, Rubens RD. Biochemical prediction of response of bone metastases to treatment. Br J Cancer 1988;58:205–210.
Pollen JJ, Shlaer WJ. Osteoblastic response to successful treatment of metastatic cancer of the prostate. Am J Radiol 1979;132:927–931.
Pollen JJ, Witztum KF, Ashburn WL. The flare phenomenon on radionuclide bone scan in metastatic prostate cancer. Am J Radiol 1984;142:773–776.
Sundkvist GMG, Ahlgren L, Lilja B, Mattsson S, Abrahamsson PA, Wadström LB. Repeated quantitative bone scintigraphy in patients with prostatic carcinoma treated with orchiectomy. Eur J Nucl Med 1988;14:203–206.
Sundkvist GMG, Ahlgren L, Lilja B, Mattsson S, Abrahamsson PA. Dynamic quantitative bone scintigraphy in patients with prostatic carcinoma treated by orchiectomy. Eur J Nucl Med 1990;16:671–676.
Cosolo W Morstyn G, Arkles, B Zimet AS, Zalcberg JR. Flare responses in small cell carcinoma of the lung. Clin Nucl Med 1988;13:13–16.
Bitran JD, Bekerman C, Desser RK. The predictive value of serial bone scans in assessing response to chemotherapy in advanced breast cancer. Cancer 1980;45:1562–1568.
Hortobagyi GN, Libshitz HI, Seabold JE. Osseous metastases of breast cancer. Clinical, biochemical, radiographic and scintigraphic evaluation of response to therapy. Cancer 1984;53:577–582.
Citrin DL, Hougen C, Zweibel W, Schlise S, Pruitt B, Ershler W Davis TE, Harberg J, Cohen AI. The use of serial bone scans in assessing response of bone metastases to systemic treatment. Cancer 1981;47:680–685.
Coombes RC, Dady P, Parsons C, McCready VR, Ford HT, Gazet JC, Powles TL. Assessment of response of bone metastases to systemic treatment in patients with breast cancer. Cancer 1983;52:610–614.
Levenson RM, Sauerbrunn BJL, Bates HR, Newman RD, Eddy JL, Ihde DC. Comparative value of bone scintigraphy and radiography in monitoring tumor response in systemically treated prostatic carcinoma. Radiology 1983;146:513–518.
Johns WD, Garnick MB, Kaplan WD. Leuprolide therapy for prostate cancer. An association with scintigraphic “flare” on bone scan. Clin Nucl Med 1990;15:485–487.
Author information
Authors and Affiliations
Additional information
Correspondence to: WD. van Schelven
Rights and permissions
About this article
Cite this article
van Schelven, W., Pauwels, E. The flare phenomenon: far from fair and square. Eur J Nucl Med 21, 377–380 (1994). https://doi.org/10.1007/BF00171410
Issue Date:
DOI: https://doi.org/10.1007/BF00171410