Abstract
The sequences of ovine and bovine placental lactogens (based on published cDNA sequences) are remarkably different, indicating a very rapid rate of evolution. Analysis of the cDNA sequences indicates that the rate of nonsynonymous substitution in these proteins is considerably greater than the rate of synonymous substitution. This is an unusual situation, which suggests that the observed rapid rate of evolution is due to incorporation of adaptive rather than neutral mutations.
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References
Bello PA, Mountford PS, Brandon MR, Adams TE (1989) Cloning and DNA sequence analysis of the cDNA for the common α-subunit of the ovine pituitary glycoprotein hormones. Nucleic Acids Res 17:10494
Colosi P, Thordarson G, Hellmiss R, Singh K, Forsyth IA, Gluckman P, Wood WI (1989) Cloning and expression of ovine placental lactogen. Mol Endocrinol 3:1462–1469
Evans MJ, Scarpulla RC (1988) The human somatic cytochrome c gene: Two classes of processed pseudogenes demarcate a period of rapid molecular evolution. Proc Natl Acad Sci USA 85:9625–9629
Garner KJ, Lingrel JB (1989) A comparison of the βA- and βB-globin gene clusters of sheep. J Mol Evol 28:175–184
Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge
Li W-H, Gojobori T (1983) Rapid evolution of goat and sheep globin genes following gene duplication. Mol Biol Evol 1:94–108
Li W-H, Graur D (1991) Fundamentals of molecular evolution. Sinauer, Sunderland, MA, pp 69–70
Maurer RA, Beck A (1986) Isolation and nucleotide sequence analysis of a cloned cDNA encoding the β-subunit of bovine follicle-stimulating hormone. DNA 5:363–369
Miller WL, Martial JA, Baxter JD (1980) Molecular cloning of DNA complementary to bovine growth hormone mRNA. J Biol Chem 255:7521–7524
Mountford PS, Bello PA, Brandon MR, Adams TE (1989) Cloning and DNA sequence analysis of the cDNA for the precursor of ovine follicle stimulating hormone β-subunit. Nucleic Acids Res 17:6391
Nei M (1987) Molecular evolutionary genetics. Columbia University Press, New York
Nei M, Gojobori T (1986) Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol Biol Evol 3:418–426
Nicoll CS, Mayer GL, Russell SM (1986) Structural features of prolactins and growth hormones that can be related to their biological properties. Endocrine Rev 7:169–203
Nilson JH, Thomason AR, Cserbak MT, Moncman CL, Woychik RP (1983) Nucleotide sequence of a cDNA for the common α-subunit of the bovine pituitary glycoprotein hormones. J Biol Chem 258:4679–4682
Ohta T (1991) Multigene families and the evolution of complexity. J Mol Evol 33:34–41
Sasavage NL, Nilson JH, Horowitz S, Rottman FM (1982) Nucleotide sequence of bovine prolactin messenger RNA. J Biol Chem 257:678–681
Schimenti JC, Duncan CH (1984) Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats. Nucleic Acids Res 12:1641–1655
Schuler LA, Shimomura K, Kessler MA, Zieler CG, Bremel RD (1988) Bovine placental lactogen: Molecular cloning and protein structure. Biochemistry 27:8443–8448
Shaw J-P, Marks J, Shen CC, Shen C-KJ (1989) Anomalous and selective DNA mutations of the Old World monkey α-globin genes. Proc Natl Acad Sci USA 86:1312–1316
Varma S, Kwok S, Ebner KE (1989) Cloning and nucleotide sequence of ovine prolactin cDNA. Gene 77:349–359
Wallis M (1981) The molecular evolution of pituitary growth hormone, prolactin and placental lactogen: A protein family showing variable rates of evolution. J Mol Evol 17:10–18
Wallis M (1992) The expanding growth hormone/prolactin family. J Mol Endocrinol 9:185–188
Warwick JM, Wallis M (1984) Characterization of mRNA sequences encoding sheep somatotropin (growth hormone) by cloning of pituitary complementary DNA. Biochem Soc Trans 12:247–248
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Wallis, M. Remarkably high rate of molecular evolution of ruminant placental lactogens. J Mol Evol 37, 86–88 (1993). https://doi.org/10.1007/BF00170466
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DOI: https://doi.org/10.1007/BF00170466