Skip to main content
SpringerLink
Log in

Abnormal sclerocytes in nanophthalmos

  • Clinical Investigations
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Scleral tissue from a nanophthalmic patient was examined morphologically and by a tissue culture method. Collagen in the unusually thickened scleral tissue was arranged in irregularly interlacing bundles. Results of tissue culture studies showed sclerocytes that seemed to secrete many granules that stained positively with Alcian blue and periodic acid-Schiff (PAS). No granules were seen in cells of scleral tissue cultured from two control eyes. These findings may be the result of the modified glycosaminoglycan metabolism, which in turn contributes to the abnormal packing of collagen bundles and thickening of sclera in nanophthalmos.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Birk DE, Silver FH (1984) Kinetic analysis of collagen fibrogenesis. II. Corneal and scleral type I collagen. Coll Relat Res 4:265–277

    Google Scholar 

  2. Borcherding MS, Black LJ, Sittig RA, Bizzell JW, Breen M, Weinstein HG (1975) Proteoglycans and collagen fibre organization in human corneoscleral tissue. Exp Eye Res 21:59–70

    Google Scholar 

  3. Brockhurst RJ (1975) Nanophthalmos with uveal effusion. A new clinical entity. Arch Ophthalmol 93:1289–1299

    Google Scholar 

  4. Duke-Elder S (1964) Normal and abnormal development. congenital deformities. In: Duke-Elder S (ed) System of ophthalmology, vol 3. Kimpton, London, pp 488–495

    Google Scholar 

  5. Forrester JV, Lee WR, Kerr PR, Dua HS (1990) The uveal effusion syndrome and trans-scleral flow. Eye 4:354–365

    Google Scholar 

  6. Myers DB, Highton TC, Rayns DG (1973) Ruthenium redpositive filaments interconnecting collagen fibrils. J Ultrastruct Res 42:87–92

    Google Scholar 

  7. Singh OS, Simmons RJ, Brockhurst RJ, Trempe CL (1982) Nanophthalmos. A perspective on identification and therapy. Ophthalmology 89:1006–1012

    Google Scholar 

  8. Trelstad RL, Silbermann NN, Brockhurst RJ (1982) Nanophthalmic sclera. Ultrastructural, histochemical, and biochemical observations. Arch Ophthalmol 100:1935–1938

    Google Scholar 

  9. Ward RC, Gragoudas ES, Pon DM, Albert DM (1988) Abnormal scleral findings in uveal effusion syndrome. Am J Ophthalmol 106:139–146

    Google Scholar 

  10. Yue BYJT, Duvall J, Goldberg MF, Puck A, Tso MOM, Sugar J (1986) Nanophthalmic sclera. Morphologic and tissue culture studies. Ophthalmology 93:534–541

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Tohoku University School of Medicine, 1-1 Seiryo-machim, Aoba-ku, 980, Sendai, Japan

    Takashi Shiono, Akiyo Shoji, Tsutomu Mutoh & Makoto Tamai

Authors
  1. Takashi Shiono
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akiyo Shoji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsutomu Mutoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Makoto Tamai
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Correspondence to: T. Shiono

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shiono, T., Shoji, A., Mutoh, T. et al. Abnormal sclerocytes in nanophthalmos. Graefe's Arch Clin Exp Ophthalmol 230, 348–351 (1992). https://doi.org/10.1007/BF00165943

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00165943

Keywords

Search

Navigation