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Effect of combined AZQ and radiation on the tolerance of the rat spinal cord

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Abstract

The effect of combined AZQ (aziridinylbenzoquinone) and ionizing radiation on the rat spinal cord has been investigated. The highest dose of AZQ (3 mg/kg) tolerated by rats weighing 250 g was injected intravenously 15 min before a single dose of radiation or the first of 2 fractional doses. The development of paralysis due to white-matter necrosis in rats of each dose group was scored and dose-response curves were constructed. It has been found that a combination of AZQ with radiation did not lead to a significant shift of the dose-response curve as compared to that of radiation alone. Thus, AZQ administered according to the schedule used in the present study did not seem to reduce the radiation tolerance of the central nervous system.

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References

  1. Khan AH, Driscoll JS: Potential central nervous system antitumor agents. Aziridinylbenzoquinone. J Med Chem 19:217–219, 1976.

    Google Scholar 

  2. Savaraj N, Lu K, Fenn LG, Leavens ME, Stewart D, Burgess MA, Benjamin RS, Loo TL: Intracerebral penetration and tissue distribution of 2,5-diaziridinyl 3, 6-BIS (carboethoxyamino) 1,4-benzoquinoe (AZQ, NSC-182986). J Neuro-Oncol 1:15–19, 1983.

    Google Scholar 

  3. Ang KK, van der Kogel AJ, van der Schueren E: Inhalation anesthesia in experimental radiotherapy: a reliable and time-saving system for multifunction studies in a clinical department. Int J Radiat Oncol Biol Phys 8:145–148, 1982.

    Google Scholar 

  4. van der Kogel AJ: The cellular basis of radiation induced damage in the CNS. In: Potten CS, Hendry JH (eds) Cytotoxic insult to tissues: effects on cell lineages. Churchill-Livingstone, Edinburgh, 1983, pp 329–352.

    Google Scholar 

  5. Finney DJ, Marcus PI: Probit analysis. A statistical treatment of the sigmoid response curve. Cambridge University Press, Cambridge, 1982.

    Google Scholar 

  6. van der Kogel AJ: Late effects of radiation on the spinal cord: dose-effect relationships and pathogenesis. Radiobiological Institute TNO, Rijswijk, The Netherlands, 1979, pp 1–160.

    Google Scholar 

  7. Driscoll JS, Dudeck L, Congleton G, Geran RI: Potential CNS antitumor agents VI. J Pharm Sci 68:185–188, 1979.

    Google Scholar 

  8. Corbett TH, Griswold DP: Degree and spectrum of anticancer agents in six colon cancer of mice. Proc Am Assoc Cancer Res 20:71, 1979.

    Google Scholar 

  9. Bender JF, Grillo-Lopez AJ, Wolf R, Dasse B: Diaziquone (AZQ). A promising new agent for brain tumors. Proceedings of 13th International Congress of Chemotherapy, Vienna, 257:56–61, 1983.

    Google Scholar 

  10. EORTC Brain Tumor Study Group: Effect of AZQ in recurring supratentorial malignant brain gliomas: a phase II study. Eur J Cancer 21:143–146, 1985.

    Google Scholar 

  11. NCI Drug Brochure, NSC-182896, 1979.

  12. Lelieveld P, Brown JM, Goffinet DR, Schoeppel SL, Scoles M: The effect of BCNU on mouse skin and spinal cord in single drug and radiation exposures. Int J Radiat Oncol Biol Phys 5:1565–1568, 1979.

    Google Scholar 

  13. Bleyer WA, Griffin TW: White matter necrosis, mineralizing microangiopathy and intellectual abilities in survivors of childhood leukemia: associations with central nervous system irradiation and methotrexate therapy. In: Gilbert HA, Kagen AR (eds) Radiation damage to the nervous system. Raven Press, New York, 1980, pp 155–174.

    Google Scholar 

  14. van der Kogel AJ, Sissingh HA: Effects of intrathecal methotrexate and cytosine arabinoside on the radiation tolerance of the rat spinal cord. Radiother Oncol (in press).

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Author notes

  1. K Kian Ang

    Present address: Department of Clinical Radiotherapy, The University of Texas MD Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, 77030, Houston, Texas, USA

  2. Albert J van der Kogel

    Present address: Los Alamos National Laboratory, Life Sciences Division, 87545, Los Alamos, New Mexico, USA

Authors and Affiliations

  1. Department of Radiotherapy, University Hospital St. Rafael, Capucijnenvoer 33, 3000, Leuven, Belgium

    K Kian Ang & Emmanuel van der Schueren

  2. Radiobiological Institute TNO, Rijswijk, The Netherlands

    Albert J van der Kogel

Authors
  1. K Kian Ang
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  2. Albert J van der Kogel
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  3. Emmanuel van der Schueren
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Ang, K.K., van der Kogel, A.J. & van der Schueren, E. Effect of combined AZQ and radiation on the tolerance of the rat spinal cord. J Neuro-Oncol 3, 349–352 (1986). https://doi.org/10.1007/BF00165585

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